期刊
VETERINARY MICROBIOLOGY
卷 171, 期 1-2, 页码 102-111出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2014.04.005
关键词
Metagenomics; Virome; Enteric virus; Felis catus; Sakobuvirus
资金
- NIH [HL105770]
- Blood Systems Research Institute
- Hungarian Scientific Research Fund [OTKA K83013]
- Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
- Biotechnology and Biological Sciences Research Council (BBSRC)
- BBSRC [BBS/E/I/00001713] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/I/00001713] Funding Source: researchfish
Humans keep more than 80 million cats worldwide, ensuring frequent exposure to their viruses. Despite such interactions the enteric virome of cats remains poorly understood. We analyzed a fecal sample from a single healthy cat from Portugal using viral metagenomics and detected five eukaryotic viral genomes. These viruses included a novel picornavirus (proposed genus Sakobuvirus) and bocavirus (feline bocavirus 2), a variant of feline astrovirus 2 and sequence fragments of a highly divergent feline rotavirus and picobirnavirus. Feline sakobuvirus A represents the prototype species of a proposed new genus in the Picornaviridae family, distantly related to human salivirus and kobuvirus. Feline astroviruses (mamastrovirus 2) are the closest known relatives of the classic human astroviruses (mamastrovirus 1), suggestive of past cross-species transmission. Presence of these viruses by PCR among Portuguese cats was detected in 13% (rotavirus), 7% (astrovirus), 6% (bocavirus), 4% (sakobuvirus), and 4% (picobirnavirus) of 55 feline fecal samples. Co-infections were frequent with 40% (4/10) of infected cats shedding more than one of these five viruses. Our study provides an initial description of the feline fecal virome indicating a high level of asymptomatic infections. Availability of the genome sequences of these viruses will facilitate future tropism and feline disease association studies. (C) 2014 Elsevier B.V. All rights reserved.
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