期刊
VETERINARY MICROBIOLOGY
卷 166, 期 1-2, 页码 35-46出版社
ELSEVIER
DOI: 10.1016/j.vetmic.2013.04.028
关键词
FMDV VP1; Sorcin; Interferon; Immunosuppression
资金
- National Natural Science Foundation of China [30725026, 31072117, 31271543]
- National Basic Research Program of China [2006CB504303]
Foot-and-mouth disease (FMD) is an acute, highly contagious animal disease caused by FMD virus (FMDV). Although FMDV-induced immunosuppression in host has been well established, the exact molecular mechanism for such induction is not very clear. We report here the identification of FMDV VP1 as an interferon-suppressor by interacting with soluble resistance-related calcium binding protein (sorcin). We found that VP1 suppressed tumor necrosis factor (TNF)-alpha or Sendai virus (SeV)-induced type I interferon response in HEK293T cells, and that this suppression could be completely abolished by knockdown of sorcin by shRNA. Furthermore, overexpression of sorcin inhibited type I interferon response. Conversely, TNF- or SeV-induced type I interferon response increased when sorcin knocked down, leading to inhibition of vesicular stomatitis virus (VSV) replication. Thus, VP1-induced suppression of type I interferon is mediated by interacting with sorcin, a protein that appears to regulate cell response to viral infections. (C) 2013 Elsevier B.V. All rights reserved.
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