期刊
VETERINARY MICROBIOLOGY
卷 165, 期 3-4, 页码 281-286出版社
ELSEVIER
DOI: 10.1016/j.vetmic.2013.03.021
关键词
CIV; Feline; H3N2
资金
- Animal, Plant & Fisheries Quarantine and Inspection Agency (QIA), Ministry of Food, Agriculture, Forestry and Fisheries, Republic of Korea [M-AD20-2010-11-014]
The interspecies transmission of avian-origin H3N2 canine influenza virus (CIV) to dogs was first reported in 2007. The present study characterized a novel CIV H3N2 isolated from cats in an animal shelter. A comparative analysis of the deduced amino acid sequences of the A/Canine/Korea/CY009/2010(H3N2)(CY009) and A/Feline/Korea/FY028/2010 (H3N2) (FY028) strains isolated from dogs and cats, respectively, in the animal shelter identified point mutations in 18 amino acid positions within eight viral genes. Interestingly, CY009 and FY028 replicated well in specific pathogen-free embiyonated chicken eggs and in mice, respectively. Mice infected with the FY028 strain exhibited significant over expression of IL-10, TNF-alpha, and IFN-gamma, (p < 0.001) at 3 days postinfection. Thus, an emergency monitoring system should be developed to identify influenza mutations that occur during interspecies transmission in companion animals and for continuous public health surveillance. (C) 2013 Elsevier B.V. All rights reserved.
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