Article
Veterinary Sciences
Pei Zhou, Junming Huang, Yanchao Li, Hui Chen, Yidan Wu, Xueying Fu, Xiangqi Hao, Qi Li, Rongyu Zeng, Guihong Zhang
Summary: Classical swine fever (CSF) is a major viral disease in pigs, with China implementing control measures and mandatory vaccination with C-strain and E2 subunit vaccines. Both C-vac and E2-vac provide complete protection, but E2-vac allows for better differentiation of vaccinated and infected animals and elicits stronger antibody responses.
VETERINARY SCIENCES
(2021)
Article
Microbiology
Qin Wang, Huanhuan Liu, Lu Xu, Junping Li, Huawei Wu, Chenghuai Yang, Xiaochun Chen, Yong Deng, Yanyong Sun, Changchun Tu, Ning Chen, Wenjie Gong, Guanghua Chen
Summary: Classical swine fever is a significant swine disease in China, and despite compulsory vaccination, sporadic outbreaks have raised questions about the virulence of prevalent subgenotype 2.1 strains. Evaluation of field isolates showed differences in virulence, supporting the use of field strain GD191 for assessing C-strain vaccine efficacy. Vaccination with C-strain vaccines provided robust antibody response and long-lasting protection against both historical genotype 1 and prevalent genotype 2 strains.
VETERINARY MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Yoko Hayama, Kotaro Sawai, Yoshinori Murato, Emi Yamaguchi, Sonoko Kondo, Takehisa Yamamoto
Summary: This study estimated the effective range of oral vaccination for wild boars against classical swine fever (CSF) by analyzing the geographical relationship between immune wild boars and vaccination points. The results showed that the effective spatial range of bait vaccination was within 500 meters of the vaccination point. Additionally, investigating susceptible wild boar habitats within a range of at least 1200 meters from a vaccination point before implementation was found to be important.
PREVENTIVE VETERINARY MEDICINE
(2023)
Article
Immunology
Tinka Jelsma, Jacob Post, Erwin van den Born, Ruud Segers, Jeroen Kortekaas
Summary: Classical swine fever is a highly contagious and deadly disease in swine, which can be effectively controlled by vaccination with the C-strain. The C-DIVA vaccine, which allows for differentiation between infected and vaccinated animals, provides excellent protection against highly virulent strains like the Brescia strain. A single vaccination with C-DIVA can protect pigs from infection.
Review
Virology
Qiang Wei, Yunchao Liu, Gaiping Zhang
Summary: Classical swine fever (CSF), caused by CSF virus (CSFV), is a devastating viral disease in swine. Conventional vaccines lack DIVA concept, but advances in biotechnology have led to the development of safer and more effective DIVA vaccines. Current options do not fully meet safety, efficacy, DIVA potential, and marketability requirements, prompting continued research for more advanced DIVA vaccines.
Article
Virology
Enkhbold Bazarragchaa, Norikazu Isoda, Taksoo Kim, Madoka Tetsuo, Satoshi Ito, Keita Matsuno, Yoshihiro Sakoda
Summary: The proportion of seropositive wild boars in Gifu prefecture increased with oral vaccination, with high virus replication and low or non-immune response animals still present after vaccination. Continuous vaccination led to an increase in seroprevalence and a decrease in CSFV-positive animals among wild boars. The epidemiological analysis based on quantitative virological outcomes provides valuable information for improving control measures for CSF in Japan and neighboring countries.
Article
Virology
Yongfeng Li, Mengqi Yuan, Yuying Han, Libao Xie, Yuteng Ma, Su Li, Yuan Sun, Yuzi Luo, Weike Li, Hua-Ji Qiu
Summary: This study identified a unique glycosylation on the E2 glycoprotein of the C-strain vaccine against classical swine fever, which is responsible for viral attenuation and protection.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Taksoo Kim, Loc Tan Huynh, Shizuka Hirose, Manabu Igarashi, Takahiro Hiono, Norikazu Isoda, Yoshihiro Sakoda
Summary: The GPE(-) strain is a live attenuated vaccine for classical swine fever developed in Japan, with a vGPE(-) clone showing good potential despite some amino acid substitutions in the original seed. Replication-competent GPE(-) seed variant clones were produced, though their interferon-inducing capacity was lower than vGPE(-).
Article
Agriculture, Dairy & Animal Science
Chia-Yi Chang, Kuo-Jung Tsai, Ming-Chung Deng, Fun-In Wang, Hsin-Meng Liu, Shu-Hui Tsai, Yang-Chang Tu, Nien-Nong Lin, Yu-Liang Huang
Summary: The study found that vaccination can still induce strong immunity in commercial herds under maternal antibody interference and can block viral transmission within these herds.
Review
Immunology
Liani Coronado, Carmen L. Perera, Liliam Rios, Maria T. Frias, Lester J. Perez
Summary: Classical swine fever is a devastating viral infectious disease that continues to pose challenges globally, with vaccination being identified as the main control measure against future outbreaks.
Article
Virology
Lihua Wang, Shijiang Mi, Rachel Madera, Yuzhen Li, Wenjie Gong, Changchun Tu, Jishu Shi
Summary: A novel competitive enzyme-linked immunosorbent assay (cELISA) based on a C-strain E-rns specific monoclonal antibody (mAb 1504) was developed to measure immune responses to C-strain vaccine and make it a DIVA-compatible vaccine.
Article
Immunology
Yusmel Sordo-Puga, Danny Perez-Perez, Carlos Montero-Espinosa, Ayme Oliva-Cardenas, Iliana Sosa-Teste, Carlos A. Duarte, Maria Pilar Rodriguez-Molto, Talia Sardina-Gonzalez, Elaine Santana-Rodriguez, Milagros Vargas-Hernandez, Yaneris Cabrera-Otano, Julio A. Ancizar-Fragoso, Yohandy Fuentes-Rodriguez, Mario Pablo Estrada, Marisela Suarez-Pedroso
Summary: The study demonstrated that E2CD154 is capable of inducing protective neutralizing antibodies in piglets with different levels of maternal antibodies and at different ages.
Article
Biochemistry & Molecular Biology
Hao Wang, Weicheng Yi, Huan Qin, Qin Wang, Rui Guo, Zishu Pan
Summary: In this study, a bivalent vaccine targeting classical swine fever virus (CSFV) and porcine epidemic diarrhea virus (PEDV) was successfully developed, demonstrating promising immunization effects and significant importance for the swine industry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Manuel V. Borca, Elizabeth Ramirez-Medina, Ediane Silva, Elizabeth Vuono, Ayushi Rai, Sarah Pruitt, Nallely Espinoza, Lauro Velazquez-Salinas, Cyril G. Gay, Douglas P. Gladue
Summary: A recombinant vaccine candidate, ASFV-G-Delta I177L, has been developed for African swine fever and shown to be safe and effective when administered orally. Animals receiving the vaccine orally were completely protected against virulent ASF challenge, with lower viremias induced compared to intramuscular administration. Additionally, ASFV-specific antibody responses did not differ between oral and intramuscular inoculations.
Article
Virology
Lihua Wang, Rachel Madera, Yuzhen Li, Douglas P. Gladue, Manuel V. Borca, Michael T. McIntosh, Jishu Shi
Summary: This study generated three porcine monoclonal antibodies (mAbs) with in vitro neutralizing activity against classical swine fever virus (CSFV), aiming to facilitate the development of passive antibody vaccines or antiviral drugs against CSFV.