Article
Veterinary Sciences
Bruno Toledo-Silva, Fernando Nogueira de Souza, Sofie Piepers, Kristien Mertens, Freddy Haesebrouck, Sarne De Vliegher
Summary: Communication via quorum sensing between non-aureus staphylococci and Staphylococcus aureus in the bovine mammary gland is underexplored. Results showed that NAS can regulate the QS system of S. aureus, with S. chromogenes and S. simulans being more effective than S. epidermidis. NAS metabolites and supernatant had greater regulatory activity over S. aureus virulence genes than NAS cells themselves.
VETERINARY RESEARCH
(2021)
Article
Immunology
Hussain A. Alabdullah, Elise Overgaard, Danielle Scarbrough, Janet E. Williams, Omid Mohammad Mousa, Gary Dunn, Laura Bond, Mark A. McGuire, Juliette K. Tinker
Summary: The study assessed the efficacy of a vaccine against S. aureus infection, showing vaccinated animals did not exhibit clinical symptoms, had enhanced immune responses, and potential protective effects.
Article
Agriculture, Dairy & Animal Science
H. Reydams, A. Wuytack, S. Piepers, K. Mertens, F. Boyen, F. N. de Souza, F. Haesebrouck, S. De Vliegher
Summary: This study assessed the genetic diversity of S. hominis isolated from different habitats and investigated their ability to utilize ferritin and lactoferrin as iron sources. The results showed that S. hominis strains can utilize ferritin to reverse the growth inhibition caused by iron deprivation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Ramamoorthy Sivakumar, Parameswaran Sree Pranav, Madhavi Annamanedi, S. Chandrapriya, Shrikrishna Isloor, Jeyaprakash Rajendhran, Nagendra R. R. Hegde
Summary: This study conducted a comprehensive analysis of bovine mastitis-associated S. aureus isolates from India using whole genome sequencing and comparative genomic analysis. The results revealed 15 different sequence types and 5 clonal complexes. The genome of Indian mastitis-associated S. aureus strains is relatively closed. Phylogenetic analysis based on SNP variation differentiated the 41 strains into six major clades. Seventeen different antimicrobial resistance genes and 108 virulence-associated genes were identified among these isolates.
Article
Microbiology
Jabin Nesaraj, Alex Grinberg, Richard Laven, Patrick Biggs
Summary: We analyzed the genomes of 188 bovine-mastitis-causing S. aureus isolates from 65 dairy farms in New Zealand over a 17-year period. The analysis revealed a dominant clonal complex (CC1/ST1) that accounted for 75% of the isolates. This clonal complex showed host adaptation to cattle and exhibited temporal clonal stability.
VETERINARY MICROBIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Minhye Shin, Daye Mun, Hye Jin Choi, Sooah Kim, Shelley M. Payne, Younghoon Kim
Summary: Staphylococcus aureus RF122 Feo system is a major pathogen causing bovine mastitis, and the new antimicrobial agent PHT-427 efficiently inhibits this system, attenuating various virulence factors related to milk quality, enhancing bacterial antibiotic susceptibility, and showing no toxicity on animal model systems.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Microbiology
Ryota Miyazawa, So Shimoda, Keiichi Matsuda, Ryuta Tobe, Tasuke Ando, Hiroshi Yoneyama
Summary: Staphylococcus aureus is a major pathogen in humans and livestock, causing serious issues such as bovine mastitis. This study monitored cases of intramammary infection caused by S. aureus in the Miyagi Prefecture, Japan, and analyzed the strains obtained from dairy farms. The study found recurrent cases of infection and identified a Methicillin-Sensitive SA (MSSA) ST398 strain isolated from mastitis-containing cows, which is the first confirmed case in Japan. The results highlight the importance of nationwide surveillance to manage the distribution of ST398 strains in dairy farms for human and animal health.
Review
Veterinary Sciences
Bruno Campos, Amy C. Pickering, Lis Souza Rocha, Ananda Pereira Aguilar, Mary Hellen Fabres-Klein, Tiago Antonio de Oliveira Mendes, J. Ross Fitzgerald, Andrea de Oliveira Barros Ribon
Summary: This review summarizes the research on bovine Staphylococcus aureus population genetics and molecular pathogenesis conducted worldwide in the past 16 years. It describes the diversity and geographical distribution of S. aureus associated with bovine mastitis, and explores the evolution of bovine S. aureus and the importance of host-adaptation in its emergence as a mastitis pathogen. The functional relevance of virulence determinants in the pathogenesis of bovine mastitis is also discussed.
BMC VETERINARY RESEARCH
(2022)
Article
Veterinary Sciences
Junjun Liu, Xin Wang, Chongliang Bi, Khalid Mehmood, Farah Ali, Jianhua Qin, Zhaoqing Han
Summary: This study investigated Staphylococcus aureus in mastitis bovine milk in Anhui and found its drug resistance and virulence genes. Understanding the drug resistance situation of S. aureus is of great importance for the prevention and treatment of public health concerns in this region.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Xiao-Yan Zhu, Meng-Ling Wang, Meng Cai, Xue-Mei Nan, Yi-Guang Zhao, Ben-Hai Xiong, Liang Yang
Summary: Mastitis is a common infectious disease in dairy farms that results in decreased milk production and quality. Staphylococcus aureus is one of the main bacteria causing subclinical mastitis. Exosomes play a role in various physiological and pathological functions by containing proteins, lipids, and nucleic acids.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Xiaozhou Wang, Mingchao Liu, Na Geng, Yongzhen Du, Zhaoming Li, Xin Gao, Bo Han, Jianzhu Liu, Yongxia Liu
Summary: Cell death and inflammation are closely linked during mastitis caused by Staphylococcus aureus. Bovine mammary epithelial cells respond to S. aureus by NLRP3 inflammasome activation, leading to cell apoptosis and pyroptosis. This cell death process is associated with caspase-1 activation.
VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Stephen W. Tuffs, Mariya Goncheva, Stacey X. Xu, Heather C. Craig, Katherine J. Kasper, Joshua Choi, Ronald S. Flannagan, Steven M. Kerfoot, David E. Heinrichs, John K. McCormick
Summary: This study reveals the pathogenic mechanism of Staphylococcal superantigens (SAgs) in bacterial infections. The findings show that SAgs promote bacterial survival by manipulating the immune response to inhibit effective clearing of the bacteria. This research provides critical therapeutic targets for preventing persistent or severe Staphylococcus aureus diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Veterinary Sciences
Bruno Toledo-Silva, Fernando N. de Souza, Kristien Mertens, Sofie Piepers, Freddy Haesebrouck, Sarne De Vliegher
Summary: The formation of biofilms in Staphylococcus aureus strains causing subclinical mastitis in dairy cows is influenced by environmental signals and communication systems, with different staphylococci species impacting S. aureus biofilm formation and dispersion. Specifically, S. chromogenes enhances biofilm formation of an agr-positive S. aureus strain, while NAS isolates suppress biofilm dispersion of S. aureus. Additionally, the effects on biofilm formation and dispersion do not depend on the capacity of NAS to repress the agr system.
VETERINARY RESEARCH
(2021)
Review
Genetics & Heredity
Floriane Laumay, Hugo Benchetrit, Anna-Rita Corvaglia, Nathalie van der Mee-marquet, Patrice Francois
Summary: The CC398 lineage of Staphylococcus aureus, initially described as livestock colonizers, has now been found to cause severe infections in humans, even in patients without contact with animals. Recent studies suggest that CC398 strains are evolving towards increased virulence and antibiotic resistance.
Article
Zoology
Zhongyong Wu, Wenzhu Li, Chunxia Ni, Zhuolin He, Xiao Hou, Wanxia Pu
Summary: This study conducted genotyping of Staphylococcus aureus isolates from clinical mastitis milk samples collected from dairy farms in 5 different provinces in China using the RAPD method. The results showed noticeable differences in genotype distribution among provinces, which may be attributed to variations in dairy farming practices, geographical environments, and antibiotic usage.
PAKISTAN JOURNAL OF ZOOLOGY
(2021)
