Article
Virology
Yasmin A. Parr, Melissa J. Beall, Julie K. Levy, Michael McDonald, Natascha T. Hamman, Brian J. Willett, Margaret J. Hosie
Summary: The study found a correlation between the strength of the humoral immune response to the FeLV SU protein and the outcome of exposure, with regressively infected cats showing higher antibody responses and virus neutralizing antibodies. This suggests that an ELISA assay for humoral response to FeLV SU can complement viral diagnostic tests in identifying regressively infected cats less likely to develop FeLV-related diseases.
Article
Virology
Juliana Giselbrecht, Stephanie Jaehne, Michele Bergmann, Marina L. Meli, Benita Pineroli, Eva Boenzli, Svenja Teichmann-Knorrn, Yury Zablotski, Maria-Grazia Pennisi, Nicolas Layachi, Rodrigo Serra, Stefano Bo, Regina Hofmann-Lehmann, Katrin Hartmann
Summary: This study investigated the prevalence of different outcomes of FeLV infection in cats in four European countries. The results showed that the prevalence of FeLV infection is still high in Italy and Portugal, while it is lower in Germany and France. In conclusion, FeLV infection still has a high prevalence, especially in Southern European countries.
Review
Microbiology
Hiroshi Kimura, Yusuke Okuno, Yoshitaka Sato, Takahiro Watanabe, Takayuki Murata
Summary: EBV, a double-stranded DNA virus, is associated with various types of lymphomas and lymphoproliferative disorders. The oncogenic mechanism, including EBV receptors on T/NK cells, relationship with host genes, and epigenetic regulation, remains unclear. However, the roles of host and viral non-coding RNAs in tumorigenesis have been elucidated.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Fabienne Sprissler, Prapaporn Jongwattanapisan, Supol Luengyosluechakul, Rosama Pusoonthornthum, Sven Reese, Michele Bergmann, Katrin Hartmann
Summary: This study investigated the prevalence of FIV and FeLV infection in healthy outdoor cats in North, Northeast and Central Thailand and evaluated the associated risk factors. The results showed that the prevalence of FIV and FeLV infections was lower than expected in these regions, and there were no significant risk factors for FeLV infection. However, the risk of FIV infection increased with age.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Virology
Giovana Biezus, Thierry Grima de Cristo, Gabriela Bassi das Neves, Mariana da Silva Casa, Paula Barros Brizola, Marina Silvestre Sombrio, Luiz Claudio Miletti, Renata Assis Casagrande
Summary: Only a few studies have investigated the impact of FeLV subgroups on disease development in spontaneously infected cats. This study identified FeLV-A and FeLV-B subgroups in cats with lymphoma and leukemia and examined the phylogenetic relationships of env sequences. The prevalence of FeLV-AB in cats with lymphoma and leukemia in Brazil highlights the genetic diversity involved in the pathogenesis of these neoplasms.
Review
Virology
Konstantina Kitsou, Pagona Lagiou, Gkikas Magiorkinis
Summary: Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from ancient exogenous retrovirus infection of human germ-line cells. Their aberrant expression is linked to human disease, including cancer. This review article discusses the presumed role of HERVs in carcinogenesis, their diagnostic and prognostic implications, and their potential as targets for cancer therapeutics. High-throughput sequencing approaches will further clarify HERV participation in human physiological and pathological processes.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Veterinary Sciences
M. C. Canto-Valdes, M. E. Bolio Gonzalez, G. E. Acevedo-Jimenez, H. Ramirez Alvarez
Summary: Feline leukaemia virus (FeLV) is a retrovirus causing neoplasms, bone marrow disorders, and immunosuppression in cats. It can mutate and recombine with ancestral retroviruses, forming a diversity of endogenous and recombinant FeLV subgroups. Recombination of the env gene is the most significant in terms of pathogenic effects, affecting viral populations, cell tropism, and disease types. This review focuses on the interaction between endogenous and exogenous viruses, exploring FeLV's genetic diversity, pathogenesis, and diagnosis.
NEW ZEALAND VETERINARY JOURNAL
(2023)
Article
Immunology
Thomas Joris, Jana Haddow, Graham P. Taylor, Lucy B. M. Cook, Aileen G. Rowan
Summary: Detection of HTLV-1 proviral DNA in blood plasma cfDNA may be used for diagnosis and monitoring of HTLV-1 carriers.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Shivam Chowdhary, Rahul Deka, Kingshuk Panda, Rohit Kumar, Abhishikt David Solomon, Jimli Das, Supriya Kanoujiya, Ashish Kumar Gupta, Somya Sinha, Janne Ruokolainen, Kavindra Kumar Kesari, Piyush Kumar Gupta
Summary: Human viral oncogenesis is a complex phenomenon that contributes significantly to the global cancer burden. Recent findings have uncovered cellular and molecular pathways involved in the development and initiation of malignancy during viral infections. Antiviral treatment has emerged as a strategy to eliminate viral infections and prevent oncogenesis. Exploring the molecular pathogenesis of various oncogenic viruses and developing potent antiviral therapies could enhance the eradication of infected malignant cells while sparing normal ones. This review discusses the advancements in natural and synthetic antivirals and highlights the challenges and future prospects of using antivirals in viral oncogenesis.
MOLECULAR PHARMACEUTICS
(2023)
Review
Immunology
Alexander Glover, Zhaoqin Zhang, Claire Shannon-Lowe
Summary: Myeloid derived suppressor cells (MDSCs) are a heterogenous population of myeloid cells derived from monocyte and granulocyte precursors. They are pathologically expanded in conditions of ongoing inflammation where they function to suppress both innate and adaptive immunity. They are associated with inhibition of the anti-tumour immune response in cancer and are universally associated with a poor prognosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Megan Roth, Yumeng Z. McDaniel, Michele B. Daly, Nathaniel Talledge, Willie M. Greggs, Steven E. Patterson, Baek Kim, Louis M. Mansky
Summary: 5-aza-C is a potent mutagen for HIV-1, but does not induce hypermutation in MuLV and FeLV. While 5-aza-dCTP significantly inhibits MuLV RT, it has no effect on HIV-1 RT. This suggests distinct antiretroviral mechanisms of action for 5-aza-C among closely related viruses.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Oncology
Meghri Katerji, Penelope J. Duerksen-Hughes
Summary: DNA lesions can arise from various sources and, if left unrepaired, can lead to mutations that promote uncontrolled cell proliferation and evasion of cell death, playing a key role in carcinogenesis. In addition, DNA damage can facilitate the integration of oncogenic DNA viruses, amplifying the impact on carcinogenesis, especially in the case of oncoviruses. Further research is needed to understand the pathways involved in DNA damage-induced viral integration and develop strategies to prevent such integration to reduce viral-induced malignancies.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Nevola, Domenico Beccia, Valerio Rosato, Rachele Ruocco, Davide Mastrocinque, Angela Villani, Pasquale Perillo, Simona Imbriani, Augusto Delle Femine, Livio Criscuolo, Maria Alfano, Marco La Montagna, Antonio Russo, Raffaele Marfella, Domenico Cozzolino, Ferdinando Carlo Sasso, Luca Rinaldi, Aldo Marrone, Luigi Elio Adinolfi, Ernesto Claar
Summary: Hepatitis B virus (HBV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Despite the availability of vaccines and antiviral agents, chronic HBV infection is difficult to eliminate due to the complex interactions between the virus and the host immune system. The integration of viral genome and the production of covalently closed circular DNA (cccDNA) contribute to viral persistence and make eradication challenging. Understanding the mechanisms of viral persistence and oncogenesis is crucial for the development of functional cures for chronic HBV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Kadi Lohmussaar, Rurika Oka, Jose Espejo Valle-Inclan, Milou H. H. Smits, Hila Wardak, Jeroen Korving, Harry Begthel, Natalie Proost, Marieke van de Ven, Onno W. Kranenburg, Trudy G. N. Jonges, Ronald P. Zweemer, Sebastiaan Veersema, Ruben van Boxtel, Hans Clevers
Summary: The study describes a long-term culturing protocol for cervical epithelia that generates 3D organoids recapitulating the two tissues of origin. By establishing a small biobank of tumoroids derived from patients, a potential role of the poorly characterized HPV30 subtype in carcinogenesis was revealed. This serves as an experimental platform for cervical (cancer) research and future personalized medicine approaches.
Article
Chemistry, Multidisciplinary
Chang Liu, Yanfeng Zhou, Xiaoyuan Ji, Hui Xie, Xingjie Hu, Min Yin, Nan Chen, Chunhai Fan, Haiyun Song
Summary: A hybrid RNA design generates oxygen in the tumor microenvironment to activate viral RNA sensors, promoting immune response against cancer cells and suppressing tumor growth and metastasis effectively.
Article
Virology
Mahdis Aghazadeh, Mang Shi, Vanessa R. Barrs, Alicia J. McLuckie, Scott A. Lindsay, Barbara Jameson, Bronte Hampson, Edward C. Holmes, Julia A. Beatty
Article
Virology
Alicia J. McLuckie, Vanessa R. Barrs, Scott Lindsay, Mahdis Aghazadeh, Cheryl Sangster, Julia A. Beatty
Review
Veterinary Sciences
John S. Munday, Claire R. Sharp, Julia A. Beatty
JOURNAL OF FELINE MEDICINE AND SURGERY
(2019)
Review
Veterinary Sciences
Julia A. Beatty, Claire R. Sharp, W. Paul Duprex, John S. Munday
JOURNAL OF FELINE MEDICINE AND SURGERY
(2019)
Article
Immunology
J. Whitney, B. Haase, J. Beatty, V. R. Barrs
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2019)
Review
Agriculture, Dairy & Animal Science
G. Samaha, J. Beatty, C. M. Wade, B. Haase
Article
Virology
Carmen Ledesma-Feliciano, Ryan M. Troyer, Xin Zheng, Craig Miller, Rachel Cianciolo, Matteo Bordicchia, Nicholas Dannemiller, Roderick Gagne, Julia Beatty, Jessica Quimby, Martin Loechelt, Sue VandeWoude
Article
Multidisciplinary Sciences
Gianvito Lanave, Paolo Capozza, Georgia Diakoudi, Cristiana Catella, Leonardo Catucci, Paola Ghergo, Fabio Stasi, Vanessa Barrs, Julia Beatty, Nicola Decaro, Canio Buonavoglia, Vito Martella, Michele Camero
SCIENTIFIC REPORTS
(2019)
Article
Immunology
J. Whitney, B. Haase, J. Beatty, V. R. Barrs
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2019)
Article
Microbiology
Francesca Caringella, Costantina Desario, Eleonora Lorusso, Ivana Pallante, Tommaso Furlanello, Gianvito Lanave, Gabriella Elia, Vito Martella, Roberta Iatta, Vanessa R. Barrs, Julia Beatty, Canio Buonavoglia, Nicola Decaro
VETERINARY MICROBIOLOGY
(2019)
Article
Virology
Patricia A. Pesavento, Kenneth Jackson, Timothy Scase, Tiffany Tse, Bronte Hampson, John S. Munday, Vanessa R. Barrs, Julia A. Beatty
Article
Agriculture, Dairy & Animal Science
Hannah Miller, Michael Ward, Julia A. Beatty
Article
Virology
Kate Van Brussel, Maura Carrai, Carrie Lin, Mark Kelman, Laura Setyo, Danielle Aberdein, Juliana Brailey, Michelle Lawler, Simone Maher, Ildiko Plaganyi, Emily Lewis, Adele Hawkswell, Andrew B. Allison, Joanne Meers, Vito Martella, Julia A. Beatty, Edward C. Holmes, Nicola Decaro, Vanessa R. Barrs
Article
Virology
Maura Carrai, Kate Van Brussel, Mang Shi, Ci-Xiu Li, Wei-Shan Chang, John S. Munday, Katja Voss, Alicia McLuckie, David Taylor, Andrew Laws, Edward C. Holmes, Vanessa R. Barrs, Julia A. Beatty
Article
Virology
Elizabeth Jenkins, Conor Davis, Maura Carrai, Michael P. Ward, Susan O'Keeffe, Martine van Boeijen, Louise Beveridge, Costantina Desario, Canio Buonavoglia, Julia A. Beatty, Nicola Decaro, Vanessa R. Barrs
Article
Veterinary Sciences
L. Alibrandi, R. Tognetti, O. Domenech, M. Croce, M. Giuntoli, G. Grosso, T. Vezzosi
Summary: This study assessed the feasibility and diagnostic reliability of a new smartphone-based ECG device in dogs, and found no significant differences compared to a traditional ECG device. The results suggest that the smartphone-based device is clinically reliable for assessing heart rate and rhythm in dogs.
VETERINARY JOURNAL
(2024)