期刊
VETERINARY JOURNAL
卷 202, 期 2, 页码 387-389出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2014.08.020
关键词
Airway; Eosinophilia; Heaves; Horse
资金
- Canadian Institutes of Health Research [102751]
- Respiratory Health Network of the FRQS for the development of the Equine Tissue Bank
- Undergraduate Student Research Award from the NSERC [415448-2011]
The objective of this study was to determine whether eosinophils infiltrate the airway wall of horses with heaves. Eosinophils were evaluated using paraffin embedded lung tissues from six heaves-affected horses in crisis and six aged-matched controls. Slides were stained using Luna's method and eosinophils enumerated using histomorphometric techniques. Total eosinophil counts (expressed per mm(2) of basement membrane) were significantly higher in the airways of controls horses than in horses with heaves. Intraluminal, intraepithelial, and airway smooth muscle eosinophils counts were also increased in control horses. The results suggest that eosinophils do not contribute to the persistent airway obstruction in heaves. (C) 2014 Elsevier Ltd. All rights reserved.
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