Article
Biochemistry & Molecular Biology
Charifa Awada, Alice Bourgeois, Sarah-Eve Lemay, Yann Grobs, Tetsuro Yokokawa, Sandra Breuils-Bonnet, Sandra Martineau, Vinod Krishna, Francois Potus, Jey Jeyaseelan, Steeve Provencher, Sebastien Bonnet, Olivier Boucherat
Summary: Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling, and the inhibition of the histone methyltransferase G9a/GLP may represent a new therapeutic approach for PAH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xia Xu, Hua Feng, Chaochao Dai, Weida Lu, Jun Zhang, Xiaosun Guo, Qihui Yin, Jianli Wang, Xiaopei Cui, Fan Jiang
Summary: The study showed that CX-5461 had good tolerance for in vivo treatments in rats with PAH, preventing pulmonary arterial remodelling, perivascular inflammation, and pulmonary hypertension, leading to improved survival. In vivo and in vitro experiments demonstrated that CX-5461 induced cell cycle arrest in human pulmonary arterial smooth muscle cells through increased activation of p53, suggesting that pharmacological inhibition of Pol I could be a novel therapeutic strategy for drug-resistant PAH.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pei-Ling Chi, Chin-Chang Cheng, Cheng-Chung Hung, Mei-Tzu Wang, Hsien-Yueh Liu, Meng-Wei Ke, Min-Ci Shen, Kun-Chang Lin, Shu-Hung Kuo, Pin-Pen Hsieh, Shue-Ren Wann, Wei-Chun Huang
Summary: This study found that levels of MMP-1 and MMP-10 were increased in the vessel wall, serum, and M1-polarized macrophages of PAH patients and PAH rodent models. MMP-10 promotes the malignant phenotype of PASMCs by promoting their proliferation and migration. Inhibition of STAT1 can suppress hypoxia-induced MMP-10 expression in M1-polarized macrophages.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Critical Care Medicine
Geraldine Vitry, Roxane Paulin, Yann Grobs, Marie-Claude Lampron, Tsukasa Shimauchi, Sarah-Eve Lemay, Eve Tremblay, Karima Habbout, Charifa Awada, Alice Bourgeois, Valerie Nadeau, Renee Paradis, Sandra Breuils-Bonnet, Florence Roux-Dalvai, Mark Orcholski, Francois Potus, Steeve Provencher, Olivier Boucherat, Sebastien Bonnet
Summary: The study identified an increased expression of detoxifying DNA enzyme NUDT1 in patients with pulmonary arterial hypertension (PAH) and animal models, with its inhibition leading to improvements in DNA damage, cell death, and vascular remodeling, as well as hemodynamics and cardiac function in animal models of PAH. These findings suggest that NUDT1 inhibitors may represent a new therapeutic option for PAH patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Physiology
Ke-Xue Li, Zi-Chao Wang, Jeremiah Ong'Achwa Machuki, Meng-Zhen Li, Yu-Jie Wu, Ming-Kai Niu, Kang-Ying Yu, Qing-Bo Lu, Hai-Jian Sun
Summary: Hypertension is a leading cause of cardiovascular morbidity and mortality, and curcumin, a phytochemical derived from turmeric, shows promise in treating hypertension-induced vascular remodeling.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud
Summary: This review summarizes the importance of cellular processes and dysfunction in the development of pulmonary arterial hypertension, as well as the roles of circulating and resident vascular cells in pulmonary vascular remodeling.
Article
Peripheral Vascular Disease
Harri Elamaa, Mika Kaakinen, Marjut Natynki, Zoltan Szabo, Veli-Pekka Ronkainen, Ville Aijala, Joni M. Maki, Risto Kerkela, Johanna Myllyharju, Lauri Eklund
Summary: The study suggests that inducible deletion of PHD2 in endothelial cells can lead to progressive lung disease, while deletion in arterial smooth muscle cells results in elevated right ventricular pressure without alterations in vascular tone regulators. Mechanistically, PHD2 inhibition in smooth muscle cells involves actin polymerization-related tension development via activated cofilin.
Article
Critical Care Medicine
Benoit Lechartier, Nihel Berrebeh, Alice Huertas, Marc Humbert, Christophe Guignabert, Ly Tu
Summary: This review discusses the origin and function of contractile cells in the pulmonary vascular wall in pulmonary arterial hypertension (PAH), as well as potential therapeutic targets and future research directions.
Article
Cardiac & Cardiovascular Systems
Christine Veith, Ipek Varturk-Ozcan, Magdalena Wujak, Stefan Hadzic, Cheng-Yu Wu, Fenja Knoepp, Simone Kraut, Aleksandar Petrovic, Marija Gredic, Oleg Pak, Monika Brosien, Marie Heimbrodt, Jochen Wilhelm, Friederike C. Weisel, Kathrin Malkmus, Katharina Schaefer, Henning Gall, Khodr Tello, Djuro Kosanovic, Akylbek Sydykov, Akpay Sarybaev, Andreas Guenther, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Grazyna Kwapiszewska, Natascha Sommer, Norbert Weissmann
Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.
Article
Physiology
Julie M. M. Lade, Manuella R. R. Andrade, Clark Undem, Jasmine Walker, Haiyang Jiang, Xin Yun, Larissa A. A. Shimoda
Summary: Exposure to hypoxia leads to structural changes in pulmonary vascular wall, including hyperplasia and migration of pulmonary arterial smooth muscle cells (PASMCs). In this study, the interaction between ezrin and NHE1 was found to increase under hypoxic conditions, promoting SMA binding and enhancing PASMC migration and proliferation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dan Li, Ning-Yi Shao, Jan-Renier Moonen, Zhixin Zhao, Minyi Shi, Shoichiro Otsuki, Lingli Wang, Tiffany Nguyen, Elaine Yan, David P. Marciano, Kevin Contrepois, Caiyun G. Li, Joseph C. Wu, Michael P. Snyder, Marlene Rabinovitch
Summary: Our studies have uncovered a metabolic-transcriptional axis explaining how dividing cells use ALDH1A3 to coordinate their energy needs with the epigenetic and transcriptional regulation of genes required for SMC proliferation. They suggest that selectively disrupting the pivotal role of ALDH1A3 in PAH SMC, but not endothelial cells, is an important therapeutic consideration.
Article
Chemistry, Medicinal
Ping Liu, Wen Huang, Yirui Ding, Jianbing Wu, Zhuangzhuang Liang, Zhangjian Huang, Weiping Xie, Hui Kong
Summary: FDCA dose-dependently attenuates SuHx-induced PAH by inhibiting both Ca2+/CaMK and Rho-kinase signaling pathways, as well as maintaining mitochondrial homeostasis, thus alleviating hypoxia-induced PASMC dysfunction.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cardiac & Cardiovascular Systems
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G. Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Chen Yan
Summary: The study revealed that PDE10A contributes to SMC proliferation and intimal hyperplasia by antagonizing the CNP/NPR2/cGMP/PKG1alpha signaling pathway, suggesting that PDE10A may be a novel drug target for treating vascular occlusive disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiaowei Nie, Chenyou Shen, Jianxin Tan, Xusheng Yang, Wei Wang, Youai Dai, Haijian Sun, Zhiyuan Wu, Jingyu Chen
Summary: The study demonstrated that Andrographolide (ANDRO) may reverse pulmonary vascular remodeling through modulation of NOX/Nrf2-mediated oxidative stress and NF-kappa B-mediated inflammation, suggesting therapeutic potential in the treatment of pulmonary hypertension.
Article
Veterinary Sciences
L. Alibrandi, R. Tognetti, O. Domenech, M. Croce, M. Giuntoli, G. Grosso, T. Vezzosi
Summary: This study assessed the feasibility and diagnostic reliability of a new smartphone-based ECG device in dogs, and found no significant differences compared to a traditional ECG device. The results suggest that the smartphone-based device is clinically reliable for assessing heart rate and rhythm in dogs.
VETERINARY JOURNAL
(2024)
