Article
Pediatrics
Kathryn Ford, Maria Peppa, Ania Zylbersztejn, Joe Curry, Ruth Gilbert
Summary: The study aims to determine the birth prevalence, maternal risk factors, and 5-year survival for isolated and complex anorectal malformations. The research found that complex anorectal malformations were associated with maternal age extremes and had lower 5-year survival rates, especially for preterm infants.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Medicine, General & Internal
Melissa A. Richard, Jenil Patel, Renata H. Benjamin, Emine Bircan, Stephen J. Canon, Lisa K. Marengo, Mark A. Canfield, A. J. Agopian, Philip J. Lupo, Wendy N. Nembhard
Summary: This study suggests that boys with hypospadias have a higher risk of co-occurring major CHDs. These findings support the consideration of additional CHD screening programs for boys born with hypospadias.
Article
Pediatrics
Janine Kroeger, Christian Guenster, Guenther Heller, Elke Jeschke, Juergen Malzahn, Dieter Grab, Klaus Vetter, Michael Abou-Dakn, Helmut Hummler, Christoph Buehrer
Summary: The study found that major congenital malformations (MCMs) are more commonly seen in infants with low birthweight or very low birthweight, and these conditions are associated with significant risk of mortality.
Article
Endocrinology & Metabolism
Ilari Kuitunen, Reijo Sund, Ulla Sankilampi
Summary: This study aimed to compare the occurrence of bone fractures in preterm and low birthweight children with full-term and normal birthweight children. The study found that very preterm newborns had a 23% lower incidence of fractures compared to term newborns, while preterm newborns had a similar fracture rate. Birthweight showed a linear increase in fracture rates, with lower birthweight associated with lower fracture incidence. Overall, children born very preterm or with extremely low birthweight have a lower incidence of fractures during childhood compared to those born full term and with normal birthweight.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Pediatrics
Kate E. Best, Nicola Miller, Elizabeth Draper, David Tucker, Karen Luyt, Judith Rankin
Summary: The study showed that the prognosis associated with HLHS in the twenty first century exceeds that of many previous population-based studies, likely due to improvements in intensive care technologies and advances in surgical techniques over the last few decades.
FRONTIERS IN PEDIATRICS
(2021)
Article
Environmental Sciences
Casey Gaughan, Keli M. Sorrentino, Zeyan Liew, Nicholaus P. Johnson, Cassandra J. Clark, Mario Soriano, Julie Plano, Desiree L. Plata, James E. Saiers, Nicole C. Deziel
Summary: This study found a positive association between living in close proximity to unconventional oil and gas development and certain birth defects in Ohio. Specifically, neural tube defects, limb reduction defects, and spina bifida were associated with UOGD exposure. However, hypospadias (males only) showed an inverse relationship with UOGD exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Si Sun, HongYang Qian, Congcong Li, Qiaohong Wang, Aimin Zhao
Summary: This study retrospectively investigated the safety of low dose aspirin (LDA) during pregnancy. The results showed that the use of aspirin did not increase the risk of fetal congenital anomalies. Additionally, a previous history of fetal abnormalities was found to be an independent risk factor for congenital anomalies.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Medicine, General & Internal
Tracey Smythe, Sara Rotenberg, Chris Lavy
Summary: This study provides a comprehensive estimate of the global prevalence of clubfoot and highlights the significant burden of this condition, particularly in low- and middle-income countries.
Article
Gastroenterology & Hepatology
Motasem Alkhayyat, Salam Bachour, Mohannad Abou Saleh, Mohammad Abureesh, Ashraf Almomani, C. Roberto Simons-Linares, Emad Mansoor, Dalbir Sandhu, Amit Bhatt, Prabhleen Chahal
Summary: This study is the largest evaluation of the epidemiology of annular pancreas to date, finding a prevalence rate of annular pancreas to be 3.4/100,000. Compared to the control group, patients with annular pancreas were more likely to have a history of alcohol use, smoking, acute pancreatitis, chronic pancreatitis, gastritis, duodenitis, jaundice, and gastrointestinal outlet obstruction.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Estifanos Baye, Firehiwot Workneh Abate, Michelle Eglovitch, Fisseha Shiferie, Ingrid E. Olson, Tigest Shifraw, Workagegnehu Tarekegn Kidane, Kalkidan Yibeltal, Sitota Tsegaye, Mulatu Melese Derebe, Sheila Isanaka, Blair J. Wylie, Rose L. Molina, Grace J. Chan, Amare Worku, Luke C. Mullany, Alemayehu Worku, Yemane Berhane, Anne C. C. Lee
Summary: This study aimed to investigate the changes in birthweight data quality and LBW prevalence before and after the implementation of a birthweight quality improvement initiative in Ethiopia. The results showed that a QI intervention can significantly improve the quality of birthweight measurements, which can have a substantial impact on estimates of LBW prevalence.
POPULATION HEALTH METRICS
(2021)
Article
Orthopedics
Susanna Heiskanen, Johanna Syvanen, Ilkka Helenius, Teemu Kemppainen, Eliisa Loyttyniemi, Mika Gissler, Arimatias Raitio
Summary: This study investigated the prevalence and mortality of congenital vertebral anomalies in Finland. The study found that the prevalence of these anomalies is increasing significantly over time. The majority of cases were associated with other major anomalies, particularly affecting the heart, limbs, and digestive system. Co-occurring anomalies and syndromes were associated with increased mortality.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Nutrition & Dietetics
Karen T. Chang, Emily D. Carter, Luke C. Mullany, Subarna K. Khatry, Simon Cousens, Xiaoyi An, Julia Krasevec, Steven C. LeClerq, Melinda K. Munos, Joanne Katz
Summary: This study evaluated the performance of the MINORMIX birthweight adjustment approach and alternative methods in rural Nepal using gold-standard measured birthweights. The results showed that the MINORMIX method generated a more accurate LBW estimate than the previously applied adjustment method.
JOURNAL OF NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Z. Yu, D. Li, L. Sun, X. Zhao, H. Chang, L. Cui, H. Zhang, X. Liu, X. Lao, Z. Wan, X. Zhang
Summary: The study investigated the incidence and trends of congenital anomalies in Central China's Henan Province from 1997 to 2019. The overall incidence increased over time, with higher rates in urban areas and among males. The incidence of neural tube defects decreased, while congenital heart disease incidence rose, making it the most common anomaly post-2013.
Article
Cardiac & Cardiovascular Systems
Kok Wai Giang, Zacharias Mandalenakis, Maria Fedchenko, Peter Eriksson, Annika Rosengren, Mikael Norman, Katarina Hanseus, Mikael Dellborg
Summary: The study assessed the birth prevalence of congenital heart disease (CHD) in Sweden over a half-century and found a significant increase in the number of cases, with the largest increase observed among patients with simple defects. Overall, cardiac interventions decreased, but interventions for the most complex CHD groups increased.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Genetics & Heredity
Jianzheng Fang, Xiaoyi Wang, Xueping Sun, Yugui Cui, Feiyang Diao, Xiaoyu Yang
Summary: Congenital absence of the vas deferens (CAVD) is a major cause of obstructive azoospermia, mainly caused by mutations of CFTR and ADGRG2. However, 10%-20% of CAVD patients still lack a clear genetic diagnosis. CFTR variants, especially 5T, play a significant role in the Chinese CAVD population. CAVD patients with hypospadias have lower testicular spermatogenesis compared to those without hypospadias.
FRONTIERS IN GENETICS
(2022)
