期刊
VETERINARY JOURNAL
卷 178, 期 2, 页码 227-232出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2007.07.027
关键词
Heaves; Chronic respiratory disease; Recurrent airway obstruction; Neutrophils; Cytokines; Chemokines; Equine
资金
- Fonds du Centenaire of the Universite de Montreal
- GREMEQ
- Merck and Co
Heaves, also known as recurrent airway obstruction, is it common condition of horses characterised by pulmonary neutrophilia and reversible airway obstruction. This study evaluated the role of neutrophils in producing cytokines and chemokines that might be involved in the recruitment and activation of inflammatory cells in horses with heaves. Peripheral neutrophils were isolated from heaves-affected (n = 9) and control (n = 4) horses before and after 5 h of natural inhalation challenge. Expression of mRNA of two pro-inflammatory cytokines, tumour necrosis factor (TNF)-alpha and interleukin (IL)-I beta, along with two chemokines, IL-8 and macrophage inflammatory protein (MIP)-2, was evaluated. After exposure to mouldy hay, horses with heaves had significant airway obstruction and increased numbers of neutrophils in bronchoalveolar lavage samples, compared to control horses. However, there were no differences in the expression of mRNAs of TNF-alpha, IL-beta, IL-8 and MIP-2 between the two groups, Suggesting that the release of cytokines and chemokines by peripheral blood neutrophils is not necessary for the development of heaves. (C) 2007 Published by Elsevier Ltd.
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