Article
Agriculture, Dairy & Animal Science
Nathalie Le Floc'h, Caroline Stephanie Achard, Francis Amann Eugenio, Emmanuelle Apper, Sylvie Combes, Helene Quesnel
Summary: Feeding sows with live yeast Saccharomyces cerevisiae var. boulardii (SB) can influence the fecal microbiota of sows and their piglets, but does not have an effect on their health and performance.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Photcharaphan Maneetong, Chutikan Srisang, Naritsara Sunanta, Praeploy Muchalintamolee, Pachara Pearodwong, Junpen Suwimonteerabutr, Fabio De Rensis, Padet Tummaruk
Summary: Treatment with PGF2α postpartum improved colostrum yield and IgG in multiparous sows, as well as increased colostrum intake of piglets. Multiple administrations of PGF2α improved milk yield and increased litter weight of piglets in primiparous sows.
Article
Agriculture, Dairy & Animal Science
S. A. Hall, M. Farish, J. Coe, E. Baker, I Camerlink, A. B. Lawrence, E. M. Baxter
Summary: This study aimed to validate plasma assays for measuring biomarkers related to maternal signalling in lactating sows' milk and saliva. The results showed higher levels of biomarkers in milk than in saliva. The measurement of TNF-alpha in pig milk for the first time revealed increased levels with larger litters, allowing for a more detailed understanding of biomarkers in milk.
Article
Engineering, Chemical
S. G. Borad, A. K. Singh, G. S. Meena, S. Arora, P. N. Raju, L. Sabikhi
Summary: A study was conducted to develop spray dried immunoglobulin-rich colostrum powder with optimized conditions, retaining 88.5% of total Igs and achieving excellent insolubility index in the powder. The rheological analysis of protein-rich preparations proved useful in optimizing the spray drying conditions without compromising protein bioactivity and reconstitution properties.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Nutrition & Dietetics
Juanjuan Guo, Minjie Tan, Jing Zhu, Ye Tian, Huanyu Liu, Fan Luo, Jianbin Wang, Yanyi Huang, Yuanzhen Zhang, Yuexin Yang, Guanbo Wang
Summary: This study provides molecular insights into the benefits of breastfeeding from COVID-19 mothers. The research shows that colostrum from COVID-19 mothers contains higher levels of total protein and upregulated immune-related proteins with antiviral properties. These findings contribute to the understanding of breastfeeding decisions during active infection.
Article
Agriculture, Dairy & Animal Science
Maria Moessler, Kathrin Rychli, Volker Michael Reichmann, Thiemo Albert, Thomas Wittek
Summary: In this study, the concentration of immunoglobulin G (IgG) in alpaca colostrum was determined and its correlations with fat, protein, lactose, and minerals were calculated. The results showed that the IgG concentration decreased significantly within the first four days after parturition. There were negative correlations between IgG and fat/lactose content, but strong positive correlations with protein, magnesium, and cobalt content. The protein concentration of colostrum could be used to estimate the IgG content.
Article
Biochemical Research Methods
Rafaela Furioso Ferreira, Thomas Blees, Farhad Shakeri, Andreas Buness, Marc Sylvester, Giovanni Savoini, Alessandro Agazzi, Vladimir Mrljak, Helga Sauerwein
Summary: This study investigates the effect of different ω-6:ω-3 ratios in the maternal diet on the milk EV proteome. EV play a crucial role in regulating the infant's immune system and growth, and any changes in the EV proteome could impact intercellular communication. This research is of significance for both basic research and applied aspects in animal nutrition and health, and may provide new insights into feeding additives.
JOURNAL OF PROTEOMICS
(2022)
Review
Agriculture, Dairy & Animal Science
A. Costa, N. W. Sneddon, A. Goi, G. Visentin, L. M. E. Mammi, E. V. Savarino, F. Zingone, A. Formigoni, M. Penasa, M. De Marchi
Summary: Mammalian colostrum, known as liquid gold, is highly valued for its essential nutrients and bioactive compounds. Bovine colostrum (BC) has emerged as an important ingredient in various industries and is increasingly in demand. However, there is limited information available regarding the market size and future developments of BC. Therefore, this review provides an overview of BC production, its pros and cons, quality assessment methods, industry applications, and the current international market for BC.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Gregory P. Chambers, William Kelton, Grant Smolenski, Emma Cuttance
Summary: The prepartum vaccination of dairy cows with a calf diarrhea vaccine increased colostral concentrations of both vaccine-specific and non-vaccine-specific immunoglobulin M. Further research is needed to investigate the mechanism behind these findings, the potential effects on other immunoglobulin classes, and the implications for calf health outcomes.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Lukasz Grzeskowiak, Eva-Maria Saliu, Anna Grete Wessels, Beatriz Martinez-Vallespin, Klaus Maenner, Jose Joaquin Ceron, Wilfried Vahjen, Juergen Zentek
Summary: Maternal dietary factors have no significant influence on the colonization of Clostridioides difficile in the neonatal piglets' intestines, regardless of whether the sows were fed diets supplemented with high-fermentable sugar beet pulp or low-fermentable lignocellulose. This study provides insights into the relationship between maternal diet and neonatal piglet gut microbiota colonization.
Review
Biochemical Research Methods
Mengyao Lu, Imann Mosleh, Alireza Abbaspourrad
Summary: Human milk oligosaccharides (HMOs) are important components in human milk, and the engineered microbial routes have been researched for large-scale production. The selection of host strains and expression of appropriate glycosyltransferase are key factors in HMOs production using engineered microbial pathways.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jakob Peder Pettersen, Eivind Almaas
Summary: Improvements have been made to a new model for predicting the temperature dependence of an organism's metabolic network, addressing the issue of multimodality and highlighting the model's inadequacy in predicting metabolic flux with current experimental data.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Andy Goldschmidt, James Kunert-Graf, Adrian C. Scott, Zhihao Tan, Aimee M. Dudley, J. Nathan Kutz
Summary: Baker's yeast is a model organism for studying morphology at the scale of multi-cell colonies, with texture score development trajectories used for hierarchical clustering.
Article
Agriculture, Dairy & Animal Science
E. C. Kessler, R. M. Bruckmaier, J. J. Gross
Summary: The study compared the quality estimation of colostrum in cows, goats, and sheep using an optical Brix refractometer. Despite distinct between-species variations in colostrum composition, Brix refractometry proved to be an acceptable tool for on-farm estimations of colostrum quality in goats and sheep.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Fang Wang, Wanning Fan, Shiyu Tian
Summary: This study investigates the impact of Saccharomyces cerevisiae on rennet-induced gelation of ultra-high temperature (UHT) milk. The results show that inoculating S. cerevisiae in UHT milk leads to an increase in ethanol content, a decrease in pH, an increase in particle size and Zeta potential, as well as an advancement and increase in the elasticity index. Additionally, the number of S. cerevisiae cells affects the structure and properties of the induced curds.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Virology
Nengwen Xia, Hui Wang, Xueliang Liu, Qi Shao, Da Ao, Yulin Xu, Sen Jiang, Jia Luo, Jiajia Zhang, Nanhua Chen, Francois Meurens, Wanglong Zheng, Jianzhong Zhu
Summary: The study revealed that p17 protein inhibits cell proliferation through inducing cell cycle arrest at the G2/M phase. Additionally, p17 triggers oxidative stress and increases intracellular reactive oxygen species (ROS) levels. Mitigating ER stress reduces ROS production and prevents the decrease in cell proliferation caused by p17.
Review
Biochemistry & Molecular Biology
Wanglong Zheng, Nengwen Xia, Jiajia Zhang, Nanhua Chen, Francois Meurens, Zongping Liu, Jianzhong Zhu
Summary: The cGAS-STING pathway is involved in triggering both canonical and non-canonical autophagy, which plays crucial roles in balancing innate immune responses, maintaining intracellular environmental homeostasis, alleviating liver injury, and limiting tumor growth and transformation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Xueliang Liu, Da Ao, Sen Jiang, Nengwen Xia, Yulin Xu, Qi Shao, Jia Luo, Heng Wang, Wanglong Zheng, Nanhua Chen, Francois Meurens, Jianzhong Zhu
Summary: African swine fever (ASF) is an acute hemorrhagic disease highly contagious and lethal to domestic pigs and wild boars. Lack of effective vaccine and treatment has resulted in significant economic losses in the global pig industry. The ASFV has a large genome encoding more than 150 proteins and evades host innate immunity via multiple viral proteins.
Article
Immunology
Yulin Xu, Mengxue Ye, Youwen Zhang, Shaohua Sun, Jia Luo, Sen Jiang, Jiajia Zhang, Xueliang Liu, Qi Shao, Qi Cao, Wanglong Zheng, Francois Meurens, Nanhua Chen, Jianzhong Zhu
Summary: This study identified TRIF and MAVS as the most effective adaptors in conferring anti-PRRSV activity, indicating the involvement of multiple pattern recognition receptor signaling pathways in anti-PRRSV innate immunity.
Article
Immunology
Da Ao, Xueliang Liu, Sen Jiang, Yulin Xu, Wanglong Zheng, Nanhua Chen, Francois Meurens, Jianzhong Zhu
Summary: The study revealed that the ectodomains of TLR8 from different species and different TLRs are intracellularly localized, with porcine, bovine, and human TLR8 ectodomains all found in cell endosomes. The signal peptide of porcine TLR8-ECD and the signaling regulator UNC93B1 are key factors determining their endosomal localization.
Article
Immunology
Jia Luo, Jiajia Zhang, Jinghua Ni, Sen Jiang, Nengwen Xia, Yiwen Guo, Qi Shao, Qi Cao, Wanglong Zheng, Nanhua Chen, Quan Zhang, Hongjun Chen, Qing Chen, Hongfei Zhu, Francois Meurens, Jianzhong Zhu
Summary: This study reveals that pS273R of ASFV acts as a negative regulator of the cGAS-STING pathway by targeting IKK epsilon, providing a new immune evasion mechanism for ASFV.
Article
Immunology
Laurence Dubreil, Mireille Ledevin, Caroline Hervet, Deborah Menard, Claire Philippe, Francois J. Michel, Thibaut Larcher, Francois Meurens, Nicolas Bertho
Summary: In this study, the complex structure of inverted porcine lymph nodes, including the interconnections between lymphatic and blood vessels and the distribution of related cells, was described using advanced microscopy tools. This is important for studying the interactions between swine pathogens and immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wanglong Zheng, Nengwen Xia, Jiajia Zhang, Qi Cao, Sen Jiang, Jia Luo, Hui Wang, Nanhua Chen, Quan Zhang, Francois Meurens, Jianzhong Zhu
Summary: The structural protein p17 of African swine fever virus interacts with STING to inhibit the cGAS-STING pathway, thus evading the host immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Francois Meurens, Fanny Renois, Alexis Bouin, Jianzhong Zhu
Article
Virology
Yulin Xu, Mengxue Ye, Shaohua Sun, Qi Cao, Jia Luo, Yuening Wang, Wanglong Zheng, Francois Meurens, Nanhua Chen, Jianzhong Zhu
Summary: The study showed that porcine CD163-expressing macrophages can support infections of PRRSV2 lineages 1, 5, and 8, providing valuable insights for PRRSV research and disease management, especially in the context of prevalent NADC30-like and NADC34-like PRRSV2 strains of lineage 1 in China.
Article
Agriculture, Dairy & Animal Science
Caroline Hervet, Frederick Bussy, Claude Le Goff, Deborah Menard, Pi Nyvall Collen, Matthieu Le Goff, Francois Meurens, Nicolas Bertho
Summary: Porcine respiratory complex syndrome has a significant economic impact on the swine breeding sector and affects the wellbeing of animals. Algal extracts show positive effects on pigs' health, with a short-term pro-inflammatory effect and inhibition of PRRSV replication. In the medium term, algal extracts exhibit anti-inflammatory effects without impacting PRRSV replication.
Article
Virology
Shaohua Sun, Yulin Xu, Ming Qiu, Sen Jiang, Qi Cao, Jia Luo, Tangjie Zhang, Nanhua Chen, Wanglong Zheng, Francois Meurens, Zongping Liu, Jianzhong Zhu
Summary: This study demonstrates that Mn2+ has antiviral effects against various animal and human viruses, including RNA and DNA viruses. The antiviral function of Mn2+ is independent of the cGAS-STING pathway. This finding provides a new target for Mn2+ antiviral therapeutics.
Review
Biochemistry & Molecular Biology
Wangli Zheng, Nanhua Chen, Francois Meurens, Wanglong Zheng, Jianzhong Zhu
Summary: This study summarizes the mechanisms by which cGAS avoids sensing self-DNA under normal physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Desheng Zhang, Sen Jiang, Nengwen Xia, Youwen Zhang, Jiajia Zhang, Anjing Liu, Chenyang Zhang, Nanhua Chen, Francois Meurens, Wanglong Zheng, Jianzhong Zhu
Summary: In this study, a simple, rapid, sensitive, and specific visual detection method for African swine fever virus (ASFV) was developed, demonstrating its potential for on-site detection of ASFV.
Article
Immunology
Sen Jiang, Jia Luo, Youwen Zhang, Qi Cao, Yuening Wang, Nengwen Xia, Wanglong Zheng, Nanhua Chen, Francois Meurens, Huiguang Wu, Jianzhong Zhu
Summary: This study reveals the species-specific differences in the cGAS-STING pathway in pigs and chickens, and identifies the motifs responsible for the species disparity. The study also demonstrates the specific and stringent role of pIRF3 in inducing IFN, which contributes to the inability of chSTING to induce IFN in mammalian cells.
JOURNAL OF IMMUNOLOGY
(2022)