Article
Microbiology
Judah Ssekitoleko, Lonzy Ojok, Ahmed Abd El Wahed, Joseph Erume, Ahmad Amanzada, ElSagad Eltayeb, Kamal H. Eltom, Julius Boniface Okuni
Summary: This review discusses the mechanisms utilized by MAP to overcome the host defense system to achieve virulence, including putative MAP virulence genes and their probable roles in comparison to other mycobacteria. It also highlights the importance of understanding MAP virulence mechanisms in controlling and preventing paratuberculosis.
Article
Veterinary Sciences
Floor Biemans, Jamie Tratalos, Sandie Arnoux, George Ramsbottom, Simon J. More, Pauline Ezanno
Summary: This study investigated the impact of observed herd characteristics on the spread of Mycobacterium avium subspecies paratuberculosis (Map) on a national scale in Ireland. The research found that the probability of introducing infected animals into a herd increases with a higher number of animals being traded and the number of herds from which animals are sourced. Herds that engage in both buying and selling a large number of animals pose the highest risk of infection to other herds.
VETERINARY RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Vincent Rochard, Thierry Cochard, Stephanie Crapart, Vincent Delafont, Jean-Louis Moyen, Yann Hechard, Franck Biet
Summary: The prevalence of Johne's disease (JD) caused by Mycobacterium avium ssp. paratuberculosis (Map) is high and poses significant economic losses in the dairy industry worldwide. Recent studies have shown that Map may hinder the eradication of bovine tuberculosis (bTB) due to frequent co-infection. This study investigates the co-occurrence of amoebae and mycobacteria in water troughs of cattle herds monitored for JD or bTB, and suggests that amoebae may play a role in the transmission of JD.
Article
Veterinary Sciences
Taylor L. T. Wherry, Shankumar Mooyottu, Judith R. Stabel
Summary: The role of vitamin D-3 in modulating immune responses in cattle, particularly in different stages of infection with Mycobacterium avium subspecies paratuberculosis (MAP), has been investigated in this study. The results suggest that vitamin D-3 can modulate cytokine signaling in cattle at different stages of infection with MAP and may have implications on disease progression.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Vincent P. Richards, Annette Nigsch, Paulina Pavinski Bitar, Qi Sun, Tod Stuber, Kristina Ceres, Rebecca L. Smith, Suelee Robbe Austerman, Ynte Schukken, Yrjo T. Grohn, Michael J. Stanhope
Summary: This study conducted a prolonged longitudinal analysis of MAP isolates and dairy cow Johne's disease phenotypes from three commercial dairy farms, identifying several genes associated with the disease. The results provide insights for improving strategies to control Johne's disease.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Alexander Byrne, Nathalie Bissonnette, Severine Ollier, Kapil Tahlan
Summary: Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's Disease (JD) in ruminants and poses significant economic loss to the global dairy industry. This study investigates the prevalence and impact of mixed strain infection (MSI) and microevolution on JD by analyzing MAP isolates from high-shedding animals. The results show evidence of MSIs and microevolution in most animals, with variations in short sequence repeats (SSRs) affecting protein products and potentially influencing the infectivity of the pathogen. These findings provide insights into the dynamics and evolution of MAP in JD.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Alexander Byrne, Nathalie Bissonnette, Severine Ollier, Kapil Tahlan
Summary: This study reveals the presence of mixed strain infection and microevolution in high-shedding animals, which could have implications for the development of Johne's Disease in dairy cattle.
MICROBIOLOGY SPECTRUM
(2023)
Review
Veterinary Sciences
Amanda Kravitz, Kevin Pelzer, Nammalwar Sriranganathan
Summary: Paratuberculosis, or Johne's Disease, is a chronic enteritis mainly affecting ruminants caused by MAP, leading to economic losses and potential zoonotic risk. The lack of effective treatments and vaccines complicates disease control strategies, while host genetics play a role in resistance and susceptibility. Candidate genes identified in studies overlap with those found in CD and tuberculosis.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Sara Corneli, Antonella Di Paolo, Nicoletta Vitale, Martina Torricelli, Linda Petrucci, Carla Sebastiani, Marcella Ciullo, Ludovica Curcio, Massimo Biagetti, Paola Papa, Silva Costarelli, Monica Cagiola, Alessandro Dondo, Piera Mazzone
Summary: The IFN-gamma assay proves to be a useful diagnostic tool in identifying early subclinical MAP-infected animals, improving management of infected cattle and monitoring potential cases. It can also help avoid false reactions to MB and is beneficial in maintaining the health status of herds.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Melina Rasper-Hossinger, Michael Biggel, Roger Stephan, Frauke Seehusen, Simone Scherrer
Summary: The study aimed to analyze strain diversity in MAP-positive fecal samples using specific SNPs to distinguish between cattle and sheep type MAP, as well as SNPs within gyrA and gyrB genes to differentiate between Types I, II, and III. MIRU-VNTR analysis using eight loci was also performed. The results showed a heterogeneity of MAP in Switzerland, with 96.7% of the samples containing C-type MAP and 3.3% containing S-type MAP.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Chris Pickrodt, Karsten Donat, Udo Moog, Heike Koehler
Summary: This study determined the presence of Mycobacterium avium subsp. paratuberculosis (MAP) in the barn environment of a paratuberculosis-infected vaccinated dairy goat herd. Environmental samples were collected and examined using culture and qPCR methods. High animal traffic areas and samples collected during the indoor season were more likely to yield positive results. Dust was found to be the most suitable material for detecting MAP DNA, while bedding was suitable for MAP culture. Environmental sampling was shown to be an effective way to detect MAP in a dairy goat herd.
Article
Agriculture, Dairy & Animal Science
Chloe Matthews, Aaron M. Walsh, Stephen V. Gordon, Bryan Markey, Paul D. Cotter, Jim O' Mahony
Summary: This study investigated the changes in the faecal microbiome of cattle exposed to MAP compared to a control group. Significant differences in taxonomic diversity and composition were observed at 3 months post inoculation, including changes in the relative abundance of Methanobrevibacter and Bifidobacterium genera.
Article
Reproductive Biology
Jessica Lobo Albuquerque Caldeira, Ana Carolina Silva Faria, Edgar Andres Diaz-Miranda, Tiago Jaquel Zilch, Sanely Lourenco da Costa Caliman, Denise Silva Okano, Jose Domingues Guimara, Junnia Luisa Pena, Wagner Faria Barbosa, Abelardo Silva Junior, Yung-Fu Chang, Maria Aparecida Scatamburlo Moreira
Summary: The study found that MAP affects the motility and vigor of bovine sperm, with higher concentrations of MAP leading to lower sperm performance. MAP was found to remain viable in samples of higher concentrations after thawing, indicating the potential transmission of this pathogen through artificial insemination.
Article
Microbiology
Razieh Eshraghisamani, Amanda J. Mirto, Joyce Wang, Marcel A. Behr, Herman W. Barkema, Jeroen De Buck
Summary: This study identified essential genes for the growth and persistence of Mycobacterium avium subsp. paratuberculosis (MAP) in the natural host body. These genes are involved in metabolism, respiration, cell wall and cell processing, virulence, and information pathway processes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
B. W. Kirkpatrick, M. E. Cooke, M. Frie, K. R. B. Sporer, B. Lett, S. J. Wells, M. Coussens
Summary: This study identified genetic variations associated with susceptibility to MAP infection in Holstein cattle through genome-wide association analysis. The results suggest that genomic selection against MAP infection is feasible in Holstein cattle.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Microbiology
Patricia Rubio Reyes, Natalie A. Parlane, D. Neil Wedlock, Bernd H. A. Rehm
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2016)
Article
Multidisciplinary Sciences
Supatsak Subharat, Dairu Shu, Tao Zheng, Bryce M. Buddle, Kan Kaneko, Sarah Hook, Peter H. Janssen, D. Neil Wedlock
Article
Immunology
Bryce M. Buddle, Dairu Shu, Natalie A. Parlane, Supatsak Subharat, Axel Heiser, R. Glyn Hewinson, H. Martin Vordermeier, D. Neil Wedlock
Article
Immunology
H. Martin Vordermeier, Gareth J. Jones, Bryce M. Buddle, R. Glyn Hewinson
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2016)
Article
Microbiology
Venkata S. R. Dukkipati, Anne L. Ridler, Keith G. Thompson, Bryce M. Buddle, Barry A. Hedgespeth, Marian Price-Carter, Douglas J. Begg, Richard J. Whittington, Brigitte Gicquel, Alan Murray
VETERINARY MICROBIOLOGY
(2016)
Review
Agriculture, Dairy & Animal Science
H. Martin Vordermeier, Gareth J. Jones, Bryce M. Buddle, R. Glyn Hewinson, Bernardo Villarreal-Ramos
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 4
(2016)
Review
Materials Science, Biomaterials
Natalie A. Parlane, Sandeep K. Gupta, Patricia Rubio-Reyes, Shuxiong Chen, Majela Gonzalez-Miro, D. Neil Wedlock, Bernd H. A. Rehm
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Review
Materials Science, Biomaterials
Natalie A. Parlane, Sandeep K. Gupta, Patricia Rubio-Reyes, Shuxiong Chen, Majela Gonzalez-Miro, D. Neil Wedlock, Bernd H. A. Rehm
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Editorial Material
Veterinary Sciences
Bryce M. Buddle, Colin G. Mackintosh
Article
Multidisciplinary Sciences
Graham Nugent, Ivor J. Yockney, E. Jackie Whitford, Martin L. Cross, Frank E. Aldwell, Bryce M. Buddle
Article
Multidisciplinary Sciences
Jason W. Lee, Natalie A. Parlane, D. Neil Wedlock, Bernd H. A. Rehm
SCIENTIFIC REPORTS
(2017)
Article
Infectious Diseases
S. Subharat, M. Wada, A. Sutar, R. Abila, S. Khounsy, C. Heuer
Summary: Livestock owners in Laos commonly purchase animals from other smallholders and sell them to traders or other smallholders, with shorter trading distances being more common than long-distance trades. Movement of grazing/fattening large ruminants between villages was reported in 30% of the villages, mostly occurring within the same district or province in short distances. The findings from this study will inform FMD spread simulation models and help authorities understand the patterns of animal movements associated with disease spread.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Jun-Hee Han, Supatsak Subharat, Masako Wada, Daan Vink, Bernard J. Phiri, Ashish Sutar, Ronello Abila, Syseng Khounsy, Cord Heuer
Summary: The foot and mouth disease (FMD) vaccination program in three provinces of Lao PDR from 2016 to 2020 had varying success in reducing the prevalence of FMD virus exposure and clinical incidence. The overall impact was marginal, with factors such as operational constraints of public veterinary services, lack of farmers' compliance, and unsustainable funding contributing to the limitations of the risk-based vaccination strategy. Consistent resource availability and higher vaccination coverage are needed to effectively control FMD in Lao PDR.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Jason W. Lee, Natalie A. Parlane, Bernd H. A. Rehm, Bryce M. Buddle, Axel Heiser
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2017)