期刊
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷 144, 期 3-4, 页码 405-409出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2011.07.023
关键词
Porcine reproductive and respiratory syndrome; CpG motif; Adjuvanticity; Immune response; Protection
资金
- Key Projects in the National Science & Technology Pillar Program of China [2006BAD31B03]
- Special Funds for Scientific Research on Public Causes [200903027]
Porcine reproductive and respiratory syndrome (PRRS) is now among the most important swine diseases that affect the Chinese swine industry. Both killed and live attenuated vaccines are currently used against the disease, but neither of them could provide full protection after vaccination. In the present study, the adjuvanticity of a plasmid containing CpG motifs (pUC18-CpG) was introduced to enhance the efficacy of a commercial PRRS live attenuated vaccine. After vaccination, PRRSV-specific antibodies, PRRSV-specific cytokines, and clinical parameters were studied and compared between different vaccinated groups. During a following challenge study, co-administration of pUC18-CpG with the vaccine could confer higher protection rate. Our results have shown that co-administration of pUC18-CpG with the vaccine could elicit more potent adaptive immune response and provide better protection. (C) 2011 Elsevier B.V. All rights reserved.
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