期刊
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷 128, 期 1-3, 页码 132-136出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2008.10.302
关键词
Equine recurrent uveitis; Autoantibodies; Autoantigens; Retina; Proteomics
资金
- SFB 571
- DFG [DE 719/1-5, 2-1]
Equine recurrent uveitis (ERU) is a wide spread disease of the eye, which is the main cause for blindness in horses worldwide. Meanwhile, ERU is also accepted as the only reliable spontaneous model for human autoimmune uveitis, We identified and characterized novel autoantigens by analyzing the autoantibody-binding pattern from ERU cases to the retinal proteome. Cellular retinaldehyde-binding protein (CRALBP) and malate dehydrogenase (MDH) were detected as novel ERU autoantigens by this approach. B- and T-cell autoreactivity was detected to both autoantigens in ERU cases. The evaluation of the pathological relevance of CRALBP and MDH brought surprising results. While CRALBP-induced uveitis with high incidence in rats and horses, MDH was only uveitogenic in Lewis rats, but not in the horse itself. (C) 2008 Elsevier B.V. All rights reserved.
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