In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui)

Pharmacophore modeling for the identification of small-molecule inhibitors of TACE

(2015) Li-Juan Liu et al.   METHODS

Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library

(2014) Dik-Lung Ma et al.   CHEMICAL COMMUNICATIONS

Discovery of a Natural Product-Like iNOS Inhibitor by Molecular Docking with Potential Neuroprotective Effects In Vivo

(2014) Hai-Jing Zhong et al.   PLoS One

Role of Migratory Inhibition Factor in Age-Related Susceptibility to Radiation Lung Injury via NF-E2–Related Factor–2 and Antioxidant Regulation

(2013) Biji Mathew et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors

(2013) Matthias P. Wymann et al.   Annals of the New York Academy of Sciences

Class specific peptide inhibitors for secretory phospholipases A2

(2013) Ajay K. Mahalka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Design and synthesis of l- and d-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase

(2013) Bhargav A. Patel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Functional disruption of macrophage migration inhibitory factor (MIF) suppresses proliferation of human H460 lung cancer cells by caspase-dependent apoptosis

(2013) Yubiao Guo et al.   Cancer Cell International

Redox Proteins as Targets for Drugs Development Against Pathogens

(2013) Daniela L. Catalano-Dupuy et al.   CURRENT PHARMACEUTICAL DESIGN

Target Sites for the Design of Anti-trypanosomatid Drugs Based on the Structure of Dihydroorotate Dehydrogenase

(2013) Matheus Pinto Pinheiro et al.   CURRENT PHARMACEUTICAL DESIGN

Current developments of macrophage migration inhibitory factor (MIF) inhibitors

(2013) Lei Xu et al.   DRUG DISCOVERY TODAY

Ca2+/calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation inHelicobacter pyloriinfection

(2013) Gunter Maubach et al.   INTERNATIONAL JOURNAL OF CANCER

Identification and verification of transthyretin as a potential biomarker for pancreatic ductal adenocarcinoma

(2013) Jiong Chen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Current Progresses of Novel Natural Products and Their Derivatives/ Analogs as Anti-Alzheimer Candidates: an Update

(2013) Lei Fang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Human Anti-Macrophage Migration Inhibitory Factor Antibodies Inhibit Growth of Human Prostate Cancer Cells In Vitro and In Vivo

(2013) F. Hussain et al.   MOLECULAR CANCER THERAPEUTICS

Identification of sanguinarine metabolites in pig liver preparations by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry

(2013) Hua-Hai Zhang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Missing the target: matrix metalloproteinase antitargets in inflammation and cancer

(2013) Antoine Dufour et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sanguinarine inhibits osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-κB and ERK signaling pathways

(2012) Haowei Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities

(2012) Carmen Blanco-Aparicio et al.   BIOCHEMICAL PHARMACOLOGY

A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease

(2012) Bohui Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sanguinarine Induces Apoptosis of HT-29 Human Colon Cancer Cells via the Regulation of Bax/Bcl-2 Ratio and Caspase-9-Dependent Pathway

(2012) Jun Sik Lee et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Protein–Ligand-Based Pharmacophores: Generation and Utility Assessment in Computational Ligand Profiling

(2012) Jamel Meslamani et al.   Journal of Chemical Information and Modeling

Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease

(2012) Ling Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors

(2012) P. L. Boyer et al.   JOURNAL OF VIROLOGY

Macrophage Migration Inhibitory Factor Induces Autophagy via Reactive Oxygen Species Generation

(2012) Yung-Chun Chuang et al.   PLoS One

A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment

(2012) Xiuxiu Li et al.   PLoS One

Crystal Structures of Two Transcriptional Regulators from Bacillus cereus Define the Conserved Structural Features of a PadR Subfamily

(2012) Guntur Fibriansah et al.   PLoS One

Kinetic characterization of the critical step in HIV-1 protease maturation

(2012) S. K. Sadiq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avibactam is a covalent, reversible, non- -lactam  -lactamase inhibitor

(2012) D. E. Ehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

sc-PDB: a database for identifying variations and multiplicity of 'druggable' binding sites in proteins

(2011) J. Meslamani et al.   BIOINFORMATICS

Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells

(2011) Ji Eun Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells

(2011) Jiri Vrba et al.   FITOTERAPIA

LmrR-mediated gene regulation of multidrug resistance in Lactococcus lactis

(2011) H. Agustiandari et al.   MICROBIOLOGY-SGM

Seasonal Variation of Bioactive Alkaloid Contents in Macleaya microcarpa (Maxim.) Fedde

(2011) Kristýna Pěnčíková et al.   MOLECULES

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

(2011) F. Zhu et al.   NUCLEIC ACIDS RESEARCH

Antiparasitic efficacy of dihydrosanguinarine and dihydrochelerythrine from Macleaya microcarpa against Ichthyophthirius multifiliis in richadsin (Squaliobarbus curriculus)

(2011) Jia-yun Yao et al.   VETERINARY PARASITOLOGY

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

In silico search for multi-target anti-inflammatories in Chinese herbs and formulas

(2010) Thomas M. Ehrman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phytochemical and antimicrobial characterization of Macleaya cordata herb

(2010) Pavel Kosina et al.   FITOTERAPIA

Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults

(2010) Somnath Mukhopadhyay et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of dietary addition of Macleaya cordata alkaloid extract on growth performance, caecal indices and breast meat fatty acids profile in male broilers

(2010) J. Juskiewicz et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Effect of sanguinarine from the leaves of Macleaya cordata against Ichthyophthirius multifiliis in grass carp (Ctenopharyngodon idella)

(2010) Jia-Yun Yao et al.   PARASITOLOGY RESEARCH

The transcription repressor NmrA is subject to proteolysis by threeAspergillus nidulansproteases

(2010) Xiao Zhao et al.   PROTEIN SCIENCE

In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus

(2010) Gao-Xue Wang et al.   VETERINARY PARASITOLOGY

Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase

(2009) Stefan Laufer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Skin tumor promotion by argemone oil/alkaloid in mice: Evidence for enhanced cell proliferation, ornithine decarboxylase, cyclooxygenase-2 and activation of MAPK/NF-κB pathway

(2009) Kausar M. Ansari et al.   FOOD AND CHEMICAL TOXICOLOGY

The Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutation I132M Confers Hypersensitivity to Nucleoside Analogs

(2009) Z. Ambrose et al.   JOURNAL OF VIROLOGY

Sanguinarine, a Benzophenanthridine Alkaloid, Induces Apoptosis in MDA-MB-231 Human Breast Carcinoma Cells through a Reactive Oxygen Species-Mediated Mitochondrial Pathway

(2008) Woo Young Choi et al.   CHEMOTHERAPY

The Role of Cartilage Oligomeric Matrix Protein (COMP) in Skeletal Disease

(2008) K. Posey et al.   CURRENT DRUG TARGETS

Thrombin induced secretion of macrophage migration inhibitory factor (MIF) and its effect on nuclear signaling in endothelium

(2008) Raj Wadgaonkar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Crystal Structures of the Streptomyces coelicolor TetR-Like Protein ActR Alone and in Complex with Actinorhodin or the Actinorhodin Biosynthetic Precursor (S)-DNPA

(2008) A.R. Willems et al.   JOURNAL OF MOLECULAR BIOLOGY