Article
Biochemistry & Molecular Biology
Yuan Su, Xuyang Gao, Yu Wang, Xuying Li, Weipeng Zhang, Junxing Zhao
Summary: This study reveals that Astragalus polysaccharide (APS) promotes the differentiation of sheep skeletal muscle satellite cells (SMSCs) by regulating miR-133a through the MAPK/ERK signaling pathway. This finding is of great significance for understanding the role of APS in the development of sheep skeletal muscle.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Huiqing Qiu, Liyan Zhang, Xinqi He, Yusen Wei, Miaoran Wang, Bin Ma, Dailun Hu, Zhongli Shi
Summary: This study demonstrates that Astragalus polysaccharide (APS) may promote angiogenesis and osteocyte proliferation in a co-culture system through the MyD88-dependent TLR4 signaling pathway. APS might represent a potential therapeutic strategy in tissue-engineered bone implantation for the treatment of large bone defects, and it has the advantage of safety. Combining traditional Chinese medicine with tissue engineering can provide further strategies for promoting the development of regenerative medicine.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Urology & Nephrology
Zedong Chen, Huiyu Liang, Xianxin Yan, Qiuer Liang, Zhenyu Bai, Ting Xie, Jiaojiao Dai, Xiaoshan Zhao, Ya Xiao
Summary: This study found that astragalus polysaccharide (APS) has a protective effect on diabetic nephropathy (DN) by regulating the Gm4126/PRLR pathway. This finding contributes to the exploration of bioactive constituents in Chinese herbs as potential treatments for DN.
Article
Oncology
Xin Gao, Chenguang Wang, Suhaib Abdelrahman, Nermin Kady, Carlos Murga-Zamalloa, Peter Gann, Maria Sverdlov, Ashley Wolfe, Avery Polk, Noah Brown, Nathanael G. Bailey, Kedar Inamdar, Sandro Casavilca-Zambrano, Jaime Montes, Carlos Barrionuevo, Luis Taxa, John Reneau, Christian W. Siebel, Ivan Maillard, Ryan A. Wilcox
Summary: Notch signaling pathway plays a crucial role in the pathogenesis of peripheral T-cell lymphoma, and Notch1 activation is associated with proliferation. Blockade of Notch1/Notch2 and DLL1/DLL4 can inhibit the proliferation of malignant T cells and tumor progression.
Article
Pharmacology & Pharmacy
Yi Wei, Ming Qi, Chao Liu, Lujia Li
Summary: This study demonstrates that Astragalus polysaccharide (APS) has anti-inflammatory and antioxidant properties and can have beneficial effects on pulmonary fibrosis. APS ameliorates lung tissue injury by inhibiting the TLR4/NF-Kappa B signaling pathway, reducing inflammatory cytokine activation, and decreasing apoptosis. APS also regulates the metabolism of gut microbiota, restoring gut dysbiosis in the IPF mice model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Wenjun Sha, Bei Zhao, Huizhen Wei, Yunyi Yang, Hongping Yin, Jie Gao, Weiwei Zhao, Wenwen Kong, Guangbo Ge, Tao Lei
Summary: The aim of this study was to investigate the modulatory effects of Astragalus polysaccharide (APS) on macrophage polarization and reveal its potential mechanisms in LPS and HG stimulated macrophages and diabetic model rats. The results showed that APS promoted macrophage polarization towards M2 by enhancing the Nrf2/HO-1 pathway, thus improving vascular endothelial dysfunction in diabetes.
Article
Cell Biology
Mingzhe Li, Fangfang Duan, Zhiqiang Pan, Xiaomei Liu, Wenli Lu, Chao Liang, Zhaoqin Fang, Peike Peng, Dongwei Jia
Summary: This study aimed to determine the effect of Astragalus polysaccharide (APS) on Doxorubicin (Dox)-induced apoptosis in hepatocellular carcinoma (HCC) and the underlying mechanism. The results showed that APS dose-dependently promoted Dox-induced apoptosis and enhanced endoplasmic reticulum (ER) stress. The combination of APS and Dox showed an advantage in inhibiting tumor growth in a xenograft tumor mouse model.
Article
Chemistry, Medicinal
Mingfei Guo, Jiarong Gao, Lei Jiang, Yaji Dai
Summary: Diabetic nephropathy is a chronic inflammatory complication of diabetes characterized by hyperglycemia, albuminuria, and edema. Astragalus polysaccharide, extracted from Astragalus membranaceus, has been used for the treatment of diabetes mellitus. This study aimed to investigate the molecular mechanism of Astragalus polysaccharide on diabetic nephropathy. The results demonstrated that Astragalus polysaccharide effectively reduced fasting blood glucose levels, improved kidney function, and alleviated renal pathological damage in diabetic nephropathy models.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Shibin Feng, Hongyan Ding, Leihong Liu, Chenglu Peng, Yingying Huang, Fuchao Zhong, Wei Li, Tingting Meng, Jinchun Li, Xichun Wang, Yu Li, Jinjie Wu
Summary: The study demonstrated that the immunoregulatory effects of Astragalus polysaccharide on RAW264.7 cells are mediated, at least in part, via the activation of the NF-kappa B p65/MAPK signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Lim Seong-Min, Park Hae-Bin, Jin Jun-O
Summary: Astragalus membranaceus polysaccharides, a major component of the root extract, have been found to modulate immune responses by activating dendritic cells and T cells. Studies show that intravenous injection of A. membranaceus polysaccharides in mice and human peripheral blood can enhance immune responses.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Orthopedics
Shenyao Zhang, Kefang Dong, Xiangjing Zeng, Fan Wang, Min Lu
Summary: This study investigated the significance of Astragalus polysaccharide (APS) in the progression of steroid-induced osteonecrosis of the femoral head (SONFH). The results showed that APS could inhibit SONFH by regulating the SP1/miR-200b-3p axis and activating the Wnt/β-catenin signaling pathway.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Medicine, Research & Experimental
Ting Yao, Jin-Mei Chen, Le-Er Shen, Yong-Sheng Yu, Zheng-Hao Tang, Guo-Qing Zang, Yi Zhang, Xiao-Hua Chen
Summary: The study showed that Astragalus polysaccharide (APS) could alleviate hepatocyte senescence by reducing oxidative stress, apoptosis, and pyroptosis, while promoting mitophagy. Experiments on aged mice demonstrated that APS had protective effects against oxidative damage, apoptosis, and inflammation.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xu-Dong Wen, Yao-Lei Zhang, Ling Yang, Zhen Ye, Guo-Chuan Fu, Yong-He Hu, Tao Pan, Qiao-Bo Ye
Summary: Angelica sinensis polysaccharide (ASP) and Astragalus membranaceus polysaccharide (AMP) can promote hepatocyte proliferation, accelerate liver regeneration, and protect the liver.
Article
Pharmacology & Pharmacy
Yanjun Chen, Jiayu Wang, Juntao Li, Jinghan Zhu, Ruoqin Wang, Qinhua Xi, Hongya Wu, Tongguo Shi, Weichang Chen
Summary: Astragalus polysaccharide (APS) demonstrated its ability to prevent ferroptosis in a murine model of experimental colitis and human Caco-2 cells by inhibiting the NRF2/HO-1 pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Jianye Yang, Leilei Qin, Jiaxing Huang, Yuwan Li, Sha Xu, Hai Wang, Sizheng Zhu, Jiawei Wang, Bo Zhu, Feilong Li, Wei Huang, Xuan Gong, Ning Hu
Summary: Astragalus polysaccharide (APS) has demonstrated the ability to inhibit osteoclast formation and differentiation, regulate inflammatory osteolysis, and potentially become an effective treatment for disorders associated with osteoclasts.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)