Review
Pharmacology & Pharmacy
Adriana Yamaguchi, Eliana Botta, Michael Holinstat
Summary: This review focuses on elucidating the biosynthesis and mechanistic signaling of eicosanoids in inflammation, as well as the pro-inflammatory and anti-inflammatory effects of these eicosanoids in the blood and vascular wall.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Noralyn Manucat-Tan, Rafaa Zeineddine Abdallah, Harsimran Kaur, Daniel Saviane, Mark R. Wilson, Amy R. Wyatt
Summary: Fibrinogen in blood plasma may have a role in antioxidant defense, as it reacts with the biological oxidant hypochlorite to form high molecular weight assemblies with potential antioxidant properties. Unlike hypochlorite-modified albumin, hypochlorite-modified fibrinogen does not induce reactive oxygen species production or cell death in immune cells. The interaction of hypochlorite with fibrinogen in plasma may reduce the accumulation of other hypochlorite-modified species, indicating a novel role for fibrinogen in blood plasma antioxidant defense.
Article
Food Science & Technology
Antonella della Malva, Aristide Maggiolino, Pasquale De Palo, Marzia Albenzio, Jose Manuel Lorenzo, Agostino Sevi, Rosaria Marino
Summary: The study found changes in hardness, chewiness, and sarcoplasmic proteins of different horse muscle tissues during aging, with differences observed after 14 days of aging. These results suggest that myofibrillar, glycolytic, and mitochondrial proteins could serve as potential muscle biomarkers for monitoring post-mortem processes and meat quality in horse meat.
Article
Food Science & Technology
Jiatao He, Lianhua Hu, Qi Deng, Lijun Sun, Yuntao Zhao, Zhijia Fang, Chen Wang, Jian Zhao
Summary: The study aimed to investigate the protective effect of carboxymethyl pachymaran (CMP) on short-term stress mice model. CMP treatment improved depression-like behavior and reversed over-expression of occludin and claudin-2 proteins in the blood-brain barrier induced by short-term stress. CMP also suppressed systemic inflammation and increased levels of propionic and valeric acids while decreasing isovaleric acid concentrations in feces. Additionally, CMP elevated hippocampal 5-hydroxytryptamine (5-HT) and norepinephrine (NE) levels.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Agriculture, Dairy & Animal Science
Anna Marei Grages, Nicole Verhaar, Christiane Pfarrer, Gerhard Breves, Marion Burmester, Stephan Neudeck, Sabine Kastner
Summary: This study compared two experimental models, low flow and no flow, to characterize the development of intestinal injury in horses. The results showed that the no flow model produced more consistent intestinal damage compared to the low flow model.
Article
Agriculture, Dairy & Animal Science
Hana Dockalova, Ladislav Zeman, Daria Baholet, Andrej Batik, Sylvie Skalickova, Pavel Horky
Summary: The study found that in horses, the digestibility of flavonolignans increased with the daily dose of milk thistle expeller and then plateaued.
Article
Veterinary Sciences
Witkowska-Pilaszewicz Olga, Cywinska Anna, Michlik-Polczynska Katarzyna, Czopowicz Michal, Strzelec Katarzyna, Biazik Anna, Parzeniecka-Jaworska Marta, Crisman Mark, Witkowski Lucjan
Summary: In ponies of different classes, all biochemical parameters, except total protein concentration, showed significant differences. The most significant difference was found in blood lactate concentrations, which were higher in the smallest ponies (class A). Muscle enzymes and urea were higher, while triglycerides and creatinine were lower than normal values for equine species in all groups of ponies. Blood lactate concentration was higher only in class A ponies compared to normal values for horses.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yoshiki Murakami, Kenji Tsukano, Haruyuki Hirata, Kazuyuki Suzuki
Summary: This study aimed to determine whether serum iron (Fe) can be used as a substitute for acute phase proteins (APPs) in cows. The study included 105 Holstein-Friesian lactating dairy cows. Plasma haptoglobin (HPT), alpha-1 acid glycoprotein (AGP), and serum Fe levels were measured, and statistical analyses were conducted. The results showed that serum Fe concentration can be used as an alternative inflammatory biomarker in cows.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi-Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Vasquez-Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, Christopher E. Gillies, Asa K. Hedman, Sile Hu, Tinchi Lin, Rajesh Mikkilineni, Rion K. Pendergrass, Corran Pickering, Bram Prins, Denis Baird, Chia-Yen Chen, Lucas D. Ward, Aimee M. Deaton, Samantha Welsh, Carissa M. Willis, Nick Lehner, Matthias Arnold, Maria A. Woerheide, Karsten Suhre, Gabi Kastenmueller, Anurag Sethi, Madeleine Cule, Anil Raj, Lucy Alnylam Human Genetics, Eugene AstraZeneca Genomics Initiative, Mary Helen Biogen Biobank Team, Eric B. Bristol Myers Squibb, Joanna M. M. Genentech Human Genetics, Hyun Min GlaxoSmithKline Genomic Sci, Mark I. Pfizer Integrative Biology, Paul Population Analytics Janssen Data Sci, Slave Regeneron Genetics Ctr, Lucy Burkitt-Gray, Eugene Melamud, Mary Helen Black, Eric B. Fauman, Joanna M. M. Howson, Hyun Min Kang, Mark I. Mccarthy, Paul Nioi, Slave Petrovski, Robert A. Scott, Erin N. Smith, Sandor Szalma, Dawn M. Waterworth, Lyndon J. Mitnaul, Joseph D. Szustakowski, Bradford W. Gibson, Melissa R. Miller, Christopher D. Whelan
Summary: The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium that characterizes the plasma proteomic profiles of over 54,000 UK Biobank participants. The study provides detailed insights into proteomic disease signatures, genetic associations, and biological mechanisms, offering a valuable resource for drug discovery and biomarker development.
Article
Entomology
Ketsarin Kamyingkird, Suchada Choocherd, Wissanuwat Chimnoi, Nutsuda Klinkaew, Chanya Kengradomkij, Pornkamol Phoosangwalthong, Nipa Thammasonthijarern, Khampee Pattanatanang, Tawin Inpankaew, Jumnongjit Phasuk, Burin Nimsuphan
Summary: This study investigates the potential vectors of African horse sickness (AHS), specifically the Culicoides species, near horse stables in Hua Hin district, Thailand. Twelve Culicoides species were identified, with C. oxystoma and C. imicola being the predominant species. These Culicoides species were found to feed on blood from horses, dogs, pigs, and humans. This study highlights the identification of potential AHS vectors and their zoonotic potential in the study area.
Article
Veterinary Sciences
Heather K. K. Knych, Daniel Weiner, Linda Harrison, Daniel S. S. McKemie
Summary: This study investigated the pharmacokinetics and pharmacodynamic effects of isoflupredone acetate following intra-articular administration in an acute synovitis model in horses. Results showed rapid decrease in concentrations of isoflupredone in blood, urine, and synovial fluid over time, with short-term effects on joint circumference and pain free joint flexion.
BMC VETERINARY RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Maciej Przewozny, Magdalena Senderska-Plonowska, Anna Rzasa, Heliodor Wierzbicki, Jacek Borkowski, Jan-Hein Swagemakers, Agnieszka Zak-Bochenek, Tadeusz Stefaniak
Summary: The study analyzes the changes in acute phase proteins in the serum of patients from the equine clinic who underwent various orthopedic procedures. The concentrations of these proteins were found to change before clinical symptoms appeared, potentially aiding in early recognition and complication prevention.
Article
Immunology
Sandra D. Taylor, Kathleen M. Ivester, Craig Stewart, Allen E. Page, David W. Horohov, Laurent L. Couetil
Summary: The study found that most racehorses had lower airway inflammation without respiratory signs or exercise intolerance. Exercise alone increased peripheral blood IL-8 gene expression. Inflammatory cytokine gene expression was not increased in BALF or resting blood in horses with subclinical lower airway inflammation, precluding its diagnostic utility in clinical practice.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Cell Biology
Ross Eric Beaumont, Emily Josephine Smith, Lexin Zhou, Neil Marr, Chavaunne T. Thorpe, Deborah Jane Guest
Summary: This study investigated the impact of Interleukin 1 beta (IL-1 beta) on equine tenocyte function and gene expression. It was found that IL-1 beta increased NF-B-K-P65 nuclear translocation and IL-6 secretion, but decreased tenocyte gel contraction and affected the expression of over 2500 genes. However, blocking the interleukin 1 receptor restored gel contraction and partially rescued gene expression, while blocking NF-B-K had no effect.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Martin Massanyi, Marko Halo, Peter Massanyi, Eva Mlynekova, Agnieszka Gren, Grzegorz Formicki, Marko Halo
Summary: The study aimed to evaluate the influence of horse training on various blood parameters. The results showed significant changes in multiple blood parameters, including minerals, hepatic function, and haematology. However, there were no visible changes in the health status of the animals throughout the experiment.
Article
Medical Laboratory Technology
Stephen A. Smith, Kurt Zimmerman, David M. Moore
CLINICS IN LABORATORY MEDICINE
(2015)
Article
Medical Laboratory Technology
Kurt Zimmerman, David M. Moore, Stephen A. Smith
CLINICS IN LABORATORY MEDICINE
(2015)
Article
Veterinary Sciences
S. D. Kemp, K. L. Zimmerman, D. L. Panciera, W. E. Monroe, M. S. Leib
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2015)
Article
Veterinary Sciences
Theresa E. Pancotto, John H. Rossmeisl, William R. Huckle, Karen D. Inzana, Kurt L. Zimmerman
RESEARCH IN VETERINARY SCIENCE
(2016)
Article
Veterinary Sciences
Nicholas J. Parkinson, Katherine E. Wilson, Geoffrey K. Saunders, Virginia A. Buechner-Maxwell, W. Kent Scarratt, R. Scott Pleasant, Rebecca A. Funk
JOURNAL OF EQUINE VETERINARY SCIENCE
(2017)
Review
Veterinary Sciences
J. S. Moore, C. Shaw, E. Shaw, V. Buechner-Maxwell, W. K. Scarratt, M. Crisman, M. Furr, J. Robertson
EQUINE VETERINARY EDUCATION
(2013)
Article
Veterinary Sciences
John H. Rossmeisl, Jeryl. C. Jones, Kurt L. Zimmerman, John L. Robertson
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2013)
Article
Veterinary Sciences
Kurt L. Zimmerman, Kate McMillan, William E. Monroe, D. Phillip Sponenberg, Nick Evans, Melissa Makris, Sarah H. Hammond, Isis Kanevsky Mullarky, Mary K. Boudreaux
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2013)
Article
Immunology
Naveen Surendran, Nammalwar Sriranganathan, Stephen M. Boyle, Elizabeth M. Hiltbold, Nancy Tenpenny, Michelle Walker, Kurt Zimmerman, Stephen Werre, Sharon G. Witonsky
Review
Pathology
Abdullah Awaysheh, Jeffrey Wilcke, Francois Elvinger, Loren Rees, Weiguo Fan, Kurt L. Zimmerman
VETERINARY PATHOLOGY
(2019)
Article
Microbiology
Briana Petruzzi, Allan Dickerman, Kevin Lahmers, William K. Scarratt, Thomas J. Inzana
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Veterinary Sciences
Nimet S. Browne, William K. Scarratt, John Robertson
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2016)
Meeting Abstract
Veterinary Sciences
S. D. Kemp, D. L. Panciera, K. L. Zimmerman, W. E. Monroe, M. S. Leib, O. I. Lanz
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2013)
Article
Veterinary Sciences
Shaadi F. Elswaifi, William K. Scarratt, Thomas J. Inzana
VETERINARY RESEARCH
(2012)
Article
Veterinary Sciences
S. D. Kemp, K. L. Zimmerman, D. L. Panciera, W. E. Monroe, M. S. Leib, O. I. Lanz
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2015)
