Article
Medicine, General & Internal
Li Qian, Jianguo Zhang, Shumin Lu, Xin He, Jia Feng, Jiahai Shi, Yifei Liu
Summary: This study aimed to investigate the relationship between tumour budding, clinicopathological characteristics of patients, and prognosis in non-small cell lung cancer. Results showed a correlation between tumour budding and spread through air spaces in adenocarcinoma patients, and a close relationship between tumour budding state and peritumoural space in squamous cell carcinoma patients. Multivariate analysis identified tumour budding, pleural and vascular invasion, spread through air spaces, tumour size, lymph node metastasis, and tumour node metastasis stage as independent risk factors for prognosis in non-small cell lung cancer patients.
Review
Agriculture, Dairy & Animal Science
Antonio Giuliano, Rodrigo S. Horta, Rafael A. M. Vieira, Kelly R. Hume, Jane Dobson
Summary: Repurposing drugs in oncology involves using off-label drugs that are licensed for non-oncological medical conditions to treat cancer. This approach offers the advantage of using already commercialized drugs with known safety profiles and mechanisms of action. This review summarizes the benefits and challenges of repurposing anti-cancer drugs, discusses relevant studies in small animal oncology, and proposes potential drugs for clinical investigation in dogs and cats.
Article
Veterinary Sciences
Matthew R. Cook, Joshua Lorbach, Brian D. Husbands, William C. Kisseberth, Sarah Samuels, Catrina Silveira, Brandan G. Wustefeld-Janssens, Raelene Wouda, Samuel Keepman, Michelle L. Oblak, Laura E. Selmic
Summary: The study evaluated the clinical outcomes and potential prognostic factors of dogs with surface osteosarcoma, showing that this type of disease has prolonged progression-free interval and overall survival time.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Review
Oncology
Alexander Ring, Bich Doan Nguyen-Straeuli, Andreas Wicki, Nicola Aceto
Summary: In recent years, advancements in technology have allowed for the identification and study of rare circulating tumor cells (CTCs) from blood samples, leading to new research fields and potential clinical applications in liquid biopsies. Analysis of CTCs has revealed unique biological characteristics, such as the presence of CTC clusters and interactions with immune or stromal cells, impacting metastasis formation and providing insights for cancer vulnerabilities. This review discusses progress in understanding the biological features of CTCs and explores the potential for designing future clinical tools to improve cancer diagnosis and treatment.
NATURE REVIEWS CANCER
(2023)
Review
Veterinary Sciences
Jonathan Bray, Will Eward, Matthew Breen
Summary: Due to the complexity of tumour biology and the connection between host tissues and molecular processes of tumour cells, relying solely on cellular margins to determine treatment success may give an incomplete interpretation. Therefore, alternative strategies such as imaging systems, molecular analysis, and biologic index development are proposed to better assess tumour recurrence risk and provide confidence in margin assessment.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Review
Veterinary Sciences
Jonathan Bray, Will Eward, Matthew Breen
Summary: The goal of cancer surgery is to completely remove the tumor, but it is difficult to determine if it has been sufficiently removed to prevent recurrence. Current methods may not accurately assess the risk of recurrence.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Review
Medicine, General & Internal
Pauline H. Lin, George Laliotis
Summary: Breast cancer remains one of the common types of malignancy worldwide, despite the advances in early detection and treatment. Extensive research has led to a better understanding of its drivers and molecular characteristics, allowing for the classification into different subtypes. These subtypes have distinct treatment approaches based on immunohistological markers and transcriptomic signatures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Catarina Peixinho, Amelia Almeida, Carla Bartosch, Monica Cruz Pires
Summary: Placental site trophoblastic tumour is a rare form of gestational trophoblastic disease, diagnosis and treatment can be challenging. A case report of a 30-year-old woman showed successful treatment with hysteroscopic biopsy and chemotherapy, and the latest follow-up indicated no recurrence or metastasis, highlighting the diagnostic and treatment strategy for placental site trophoblastic tumour.
Review
Engineering, Biomedical
Patrick M. Williamson, Benjamin R. Freedman, Nicholas Kwok, Indeevar Beeram, Jan Pennings, Jeremy Johnson, Daron Hamparian, Emily Cohen, Jenna L. Galloway, Arun J. Ramappa, Joseph P. DeAngelis, Ara Nazarian
Summary: Tendinopathy is a debilitating disease that causes 30% of musculoskeletal consultations, with varying treatment efficacy possibly due to incomplete characterization of its pathophysiology. Mechanical load has both beneficial and detrimental effects on tendons based on the degree, frequency, timing, and magnitude. Utilization of small animal models to mimic human tendinopathy could provide insights into the continuum between normal tendon and tendinopathy.
ACTA BIOMATERIALIA
(2021)
Article
Multidisciplinary Sciences
Seung-hwan Jeong, Myung Jin Yang, Seunghyeok Choi, JungMo Kim, Gou Young Koh
Summary: STING agonists have been shown to induce early apoptosis of endothelial cells in subcutaneous xenografts models, while additional inhibition of AKT is required for efficient induction of apoptosis in primary tumors. This study proposes a more advanced avenue for treating primary tumors that are refractory to single STING agonist therapy.
NATURE COMMUNICATIONS
(2021)
Article
Infectious Diseases
Katharine Costa dos Santos, Rafael Marin Chiummo, Anja Regina Heckeroth, Eva Zschiesche, Paula Elisa Brandao Guedes, Tatiani Vitor Harvey, Anderson Vieira de Jesus, Anaia da Paixao Seva, Joana Thaisa Santos de Oliveira, Zelina dos Santos Freire, Juergen Krucken, Fernando de Almeida Borges, Georg Von Samson-Himmelstjerna, Renata Santiago Alberto Carlos
Summary: This study evaluated the therapeutic and residual efficacy of fluralaner for treating tungiasis in dogs. The results showed that a single oral administration of fluralaner is effective in treating and achieving long-lasting prevention for tungiasis in dogs.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Nobutaka Kawamoto, Yasuhiro Tsutani, Atsushi Kamigaichi, Manato Ohsawa, Takahiro Mimae, Yoshihiro Miyata, Morihito Okada
Summary: This study aimed to determine the frequency and predictors of occult hilar nodal metastasis (OHNM) in patients with clinical stage I non-small-cell lung cancer. The results showed that tumor location is the most important predictor of OHNM.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cell Biology
Elham Shakiba, Ali Bazi, Hamed Ghasemi, Reza Eshaghi Gorji, Seyyed Alireza Mehdipour, Banafsheh Nikfar, Mohsen Rashidi, Sepideh Mirzaei
Summary: This study evaluated the therapeutic potential of hesperidin in mice with 4T1 breast cancer tumors. The results showed that combination treatment with hesperidin and doxorubicin significantly improved survival rates and reduced the expression of tumor-related biomarkers compared to hesperidin or doxorubicin alone. Additionally, this combination treatment had a significant impact on the pathological response of tumor tissues. This suggests that hesperidin may be a potentially suitable anti-cancer agent for breast cancer and can synergize with other chemotherapeutics.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Nanoscience & Nanotechnology
Rodrigo Curvello, Verena Kast, Paloma Ordonez-Moran, Alvaro Mata, Daniela Loessner
Summary: Biology can be used to design materials and approaches for tumour tissue engineering, and biomaterials are necessary for rebuilding tissue organization, composition, and function. This review discusses bioengineering strategies that recreate the pathophysiology of tumour tissues to address questions in cancer research. Tissue engineering has produced innovative tools for cancer research.
NATURE REVIEWS MATERIALS
(2023)
Article
Veterinary Sciences
Koangyong Sung, Kenji Hosoya, Yusuke Murase, Tatsuya Deguchi, Sangho Kim, Takafumi Sunaga, Masahiro Okumura
Summary: Recent studies have shown that tumor cells with low proteasome activity exhibit CSC-like properties, which can be utilized for the identification and isolation of CSCs in canines.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)