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Biochemistry & Molecular Biology
Madhusudana Somegowda, S. Raghavendra, Shankarappa Sridhara, Achur N. Rajeshwara, Siddanakoppalu N. Pramod, S. Shivashankar, Feng Lin, Tarek K. Zin El-Abedin, Shabir Hussain Wani, Hosam O. Elansary
Summary: The melon fly infestation leads to increased oxidative damage in cucurbit fruits, but certain cucurbit species exhibit higher levels of defensive enzymes and antioxidant capabilities, showing resistance to the infestation.
Article
Biochemistry & Molecular Biology
Hyo Seong Ji, Seoung Gun Bang, Min-A Ahn, Gayeon Kim, Eunhui Kim, Seung Hee Eom, Tae Kyung Hyun
Summary: This study found that heat stress can induce the activities of Cu/ZnSODs, FeSODs, and MnSODs in garlic leaves, and the cloned AsSODs encode functional SOD enzymes belonging to the Cu/ZnSOD and MnSOD families. These results provide a solid foundation for an in-depth analysis of the physiological functions of the AsSOD family in garlic plants.
Article
Biochemistry & Molecular Biology
Merce Sunyer-Figueres, Albert Mas, Gemma Beltran, Maria-Jesus Torija
Summary: This study aimed to investigate the protective effect of melatonin on yeast cells subjected to ethanol stress during alcoholic fermentation. The results showed that melatonin supplementation can alleviate the damage caused by ethanol, promote cell growth, and reduce oxidative stress.
Review
Biochemistry & Molecular Biology
Arianna Carolina Rosa, Daniele Corsi, Niccolo Cavi, Natascia Bruni, Franco Dosio
Summary: Superoxide dismutases (SODs) are metalloenzymes that play a crucial role in antioxidant defense against oxidative stress. While SOD supplementation may help neutralize free-radical excess, clinical evidence for its efficacy is currently lacking.
Review
Biochemistry & Molecular Biology
Francesco Caruso, Sandra Incerpi, Jens Pedersen, Stuart Belli, Sarjit Kaur, Miriam Rossi
Summary: Polyphenols have been found to reform themselves after scavenging superoxide radicals, similar to the catalytic cycle of superoxide dismutase (SOD) enzyme. The interaction between polyphenols and superoxide results in oxidation of the latter and the formation of other reaction products. The low concentration of polyphenols in biological fluids does not limit their ability to effectively scavenge superoxide.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biophysics
Clarinda Costa, Zehua Liu, Sandra Simoes, Alexandra Correia, Antti Rahikkala, Jani Seitsonen, Janne Ruokolainen, Ana Aguiar-Ricardo, Helder A. Santos, M. Luisa Corvo
Summary: The study successfully encapsulated Cu,Zn-Superoxide dismutase (SOD) into liposomes using a glass-capillary microfluidic technique, demonstrating significant therapeutic effects in mouse experiments. SOD@Liposomes exhibit high encapsulation efficiency and enzyme activity, and can effectively inhibit edema through intravenous administration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Pengfei Zhai, Yinyan Ma, Huan Xu, Ling Lu
Summary: This study demonstrates that MtmA is involved in responding to oxidative stress by activating mitochondrial SodB activity in A. fumigatus. MtmA, especially for the first Mito-carr domain, is essential for colony growth by regulating cellular Zn2+ equilibrium and responses to oxidative stress. This study reveals the vital and unique role of the MtmA protein in pathogenic fungi, suggesting its potential as a target for antifungal drugs.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Arianna Carolina Rosa, Natascia Bruni, Giorgia Meineri, Daniele Corsi, Niccolo Cavi, Daniela Gastaldi, Franco Dosio
Summary: The review discusses the potential harms of overproduction of free radicals and the importance of SOD supplementation in reducing oxidative stress. It also explores various methods and strategies to improve the bioavailability of SOD in recent years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Multidisciplinary
Tian Li, Huang Cai-min, Zhang Dan-dan, Li Ran, Chen Jie-yin, Sun Wei-xia, Qiu Nian-wei, Dai Xiao-feng
Summary: VdSOD5 in V. dahliae is a novel virulence factor that combats host-derived ROS and plays an important role in the early stages of infection, while showing reduced SOD activity in vitro.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Review
Biochemistry & Molecular Biology
Brianne R. O'Leary, Rory S. Carroll, Garett J. Steers, Jennifer Hrabe, Frederick E. Domann, Joseph J. Cullen
Summary: Reactive oxygen species are essential components in cell signaling and immune responses, but an imbalance can lead to oxidative stress. Cancer cells show increased oxidative stress and decreased expression of extracellular superoxide dismutase, an antioxidant enzyme that plays a role in maintaining redox balance and protecting against oxidative damage. Understanding the role of EcSOD in cancer could have potential implications for detection, prognosis, and treatment of malignancies.
Article
Agricultural Engineering
Bhawana Mishra, Muktesh Chandra, Deepak Pant
Summary: The study evaluated the genetic, antioxidant compound, and metabolite activities of medicinal and aromatic plants with phytoremediation potential. The research demonstrated that these plants possess characteristics related to antioxidants, phytoremediation, and stress tolerance.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Engineering, Biomedical
Tao Gui, Lijun Luo, Bonirath Chhay, Leilei Zhong, Yulong Wei, Lutian Yao, Wei Yu, Jun Li, Charles L. Nelson, Andrew Tsourkas, Ling Qin, Zhiliang Cheng
Summary: Oxidative stress and reactive oxygen species play important roles in the development and progression of osteoarthritis (OA). This study utilized SOD-loaded nanoparticles to deliver antioxidant enzymes to mouse knee joints, demonstrating the accumulation of nanoparticles in the synovium and reduction of oxidative damage. Intra-articular injections of the nanoparticles were effective in attenuating OA initiation and progression, via reduction of reactive oxygen species production and catabolic protease synthesis.
Article
Biochemistry & Molecular Biology
Huize Chen, Jinsu Lee, Jung-Min Lee, Minsoo Han, Aurelia Emonet, Jiyoun Lee, Xingtian Jia, Yuree Lee
Summary: Reactive oxygen species (ROS) play essential roles in plant physiological processes and can have both beneficial and harmful effects. This study identified a putative manganese SOD, MSD2, which is secreted and regulates ROS metabolism in the roots, thereby influencing root growth and development.
Article
Plant Sciences
Gregorio Barba-Espin, Christian Martinez-Jimenez, Alberto Izquierdo-Martinez, Jose R. Acosta-Motos, Jose A. Hernandez, Pedro Diaz-Vivancos
Summary: Hairy roots grown in vitro, particularly from black carrot, were used in this study for their ability to accumulate anthocyanin. By modulating growth medium composition and H2O2 elicitation, anthocyanin accumulation and biomass production were enhanced. Elicitation with H2O2 led to increased superoxide dismutase activity and anthocyanin accumulation in the hairy roots.
Article
Biochemistry & Molecular Biology
Arpita Basu, Kenneth Izuora, Nancy M. Betts, Jeffrey L. Ebersole, Robert Hal Scofield
Summary: This study demonstrated that consuming strawberries for four weeks significantly improves antioxidant status, endothelial function, and inflammation in adults with cardiometabolic risks. These findings suggest that strawberries may be beneficial for individuals with features of metabolic syndrome.