Review
Virology
Mohammad Fereidouni, Dmitry A. Apanaskevich, David B. Pecor, Natalia Yu. Pshenichnaya, Gulzhan N. Abuova, Farida H. Tishkova, Yekaterina Bumburidi, Xiankun Zeng, Jens H. Kuhn, Maryam Keshtkar-Jahromi
Summary: This study summarizes the status of Crimean-Congo hemorrhagic fever (CCHF) in Central, Eastern, and South-eastern Asia. The risk and burden of CCHF were assessed based on case reports, antibody prevalence, and vector ticks isolation. The majority of cases were reported in Central Asia, while only China reported cases in Eastern Asia. No cases were reported in South-eastern Asia. Countries were classified into different levels based on evidence of CCHF, guiding the strengthening or establishment of CCHF surveillance systems.
Review
Microbiology
Aranzazu Portillo, Ana M. Palomar, Paula Santibanez, Jose A. Oteo
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a potentially fatal virus transmitted by ticks, widely distributed in Africa, Asia, and Europe. Recent cases in Western Europe and Spain suggest the possibility of virus transmission through ticks and migratory birds.
Article
Pharmacology & Pharmacy
Sergio E. Rodriguez, David W. Hawman, Teresa E. Sorvillo, T. Justin O'Neal, Brian H. Bird, Luis L. Rodriguez, Eric Bergeron, Stuart T. Nichol, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Summary: This article reviews the progress in immunobiology research of Crimean-Congo hemorrhagic fever virus (CCHFV), including the relationship between different outcomes and disease severity, and provides recommendations for future research.
ANTIVIRAL RESEARCH
(2022)
Review
Virology
Shiyu Dai, Fei Deng, Hualin Wang, Yunjia Ning
Summary: Crimean-Congo hemorrhagic fever virus is a tick-borne pathogen that causes severe illness and has limited treatment options without FDA-approved vaccines or specific antiviral medications. The risk of transmission has increased due to climate change and globalization, highlighting the need for greater efforts in finding therapeutic approaches.
Article
Infectious Diseases
Stella A. Atim, Shirin Ashraf, Sandra Belij-Rammerstorfer, Anna R. Ademun, Patrick Vudriko, Teddy Nakayiki, Marc Niebel, James Shepherd, Stephen Balinandi, Gladys Nakanjako, Andrew Abaasa, Paul C. D. Johnson, Steven Odongo, Martin Esau, Milton Bahati, Pontiano Kaleebu, Julius J. Lutwama, Charles Masembe, Teresa Lambe, Emma C. Thomson, Robert Tweyongyere
Summary: The study reveals a high prevalence of Crimean-Congo Haemorrhagic Fever (CCHF) in livestock farming communities in Uganda, with factors such as livestock farming, age, and collecting/eating engorged ticks associated with human seropositivity. This emphasizes the importance of further surveillance and control measures against the disease.
JOURNAL OF INFECTION
(2022)
Article
Immunology
Boushab Mohamed Boushab, Pauline K. Yanogo, Djibril Barry, Hacen Ahmed Benane, Ahmed El Bara, Moussa Abdellah, Leonardo K. Basco, Nicolas Meda
Summary: Crimean-Congo hemorrhagic fever (CCHF), a tick-borne disease with a risk of human-to-human transmission, was investigated during an outbreak in 2022. Out of 88 suspected cases, 7 were confirmed positive for CCHF through RT-PCR. All patients had potential exposure to risk factors. The study emphasizes the importance of vector control, avoiding contact and consumption of infected animal products, and animal vaccination for disease prevention.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Virology
Makgotso Golda Maotoana, Felicity Jane Burt, Dominique Goedhals
Summary: This study investigates the specific T cell response to viral proteins in survivors of Crimean-Congo hemorrhagic fever. The results suggest the presence of a long-lasting T cell memory response, particularly targeting the NSM and GP38 proteins, in survivors of infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Medicine, General & Internal
Aykut Ozdarendeli
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly infectious virus transmitted to humans through tick bites or contact with infected animal blood, causing severe symptoms and a high mortality rate. The lack of effective medical countermeasures and its potential for global spread have made CCHFV a high-priority pathogen. Recent advances in biotechnology and suitable animal models have accelerated the development of CCHFV vaccines.
Article
Immunology
Johan Espunyes, Oscar Cabezon, Lola Pailler-Garcia, Andrea Dias-Alves, Lourdes Lobato-Bailon, Ignasi Marco, Maria P. Ribas, Pedro E. Encinosa-Guzman, Marta Valldeperes, Sebastian Napp
Summary: A serosurvey in Catalonia, northeastern Spain, found high seroprevalence of Crimean-Congo hemorrhagic fever virus antibodies in southern Catalonia, indicating potential presence of competent virus vectors in the region.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Anabel Negredo, Rafael Sanchez-Arroyo, Francisco Diez-Fuertes, Fernando de Ory, Marco Antonio Budino, Ana Vazquez, Angeles Garcinuno, Lourdes Hernandez, Cesar de la Hoz Gonzalez, Almudena Gutierrez-Arroyo, Carmen Grande, Paz Sanchez-Seco
Summary: In August 2018, a fatal autochthonous case of Crimean-Congo hemorrhagic fever was confirmed in western Spain, with a new virus circulating as the genotype differs from a previous case in 2016. Practitioners must remain alert to the possibility of new cases.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Engin Berber, Nurettin Canakoglu, Sukru Tonbak, Aykut Ozdarendeli
Summary: This study evaluated the immunogenicity and immune response durations of cell-culture-derived inactivated vaccine (CCVax) and mouse-brain-derived vaccine (MBVax) for Crimean-Congo hemorrhagic fever (CCHF). The results showed that CCVax induced higher humoral and neutralizing antibody responses at all measured time points compared to MBVax.
Article
Multidisciplinary Sciences
Anoop T. Ambikan, Nazif Elaldi, Sara Svensson- Akusjaervi, Binnur Bagci, Ayse Nur Pektas, Roger Hewson, Gokhan Bagci, Mehmet Arasli, Sofia Appelberg, Adil Mardinoglu, Vikas Sood, Akos Vegvari, Rui Benfeitas, Soham Gupta, Ilhan Cetin, Ali Mirazimi, Ujjwal Neogi
Summary: This study analyzed the trajectory of host response and metabolic changes following CCHFV infection, revealing that antiviral immune responses are regulated by genes and signaling pathways. The reorganization of metabolism during the acute phase contributes to pathogenicity, while downregulated metabolic processes during the convalescent phase may lead to metabolic rewiring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Virology
Massab Umair, Zaira Rehman, Syed A. A. Haider, Qasim Ali, Rabia Hakim, Shaheen Bibi, Muhammad Salman, Aamer Ikram
Summary: This study aimed to investigate the genomic diversity of the CCHF virus circulating in Punjab and Khyber Pakhtunkhwa provinces of Pakistan. Out of the 46 tested samples from suspected CCHF patients, 6 showed positive RT-PCR results. Whole-genome sequencing of four positive samples revealed the presence of a reassorted virus with a unique segment pattern. Mutational analysis showed several mutations in different domains of the virus. These findings emphasize the importance of whole-genome sequencing in understanding the evolution of CCHFV in Pakistan.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Ayman Ahmed, Yousif Ali, Bashir Salim, Isabelle Dietrich, Jakob Zinsstag
Summary: This study reviewed the epidemiological reports of Crimean-Congo hemorrhagic fever (CCHF) in Sudan between 2010 and 2020. It identified 88 cases of CCHF, including 13 fatalities, with the majority concentrated in the Kordofan region. The study calls for the establishment of a genomic-based integrated One Health surveillance and response system.
Article
Immunology
Thomas Tipih, Mark Heise, Felicity Jane Burt
Summary: This study demonstrated the expression of CCHFV nucleoprotein by a Sindbis virus vector and its immunogenicity in mice. The induced immune response, predominantly Th1-type, was shown by the spectrum of cytokine production and antibody profile. Further studies in CCHFV-susceptible animals are needed to evaluate the protective efficacy of the vaccine.
Biographical-Item
Biotechnology & Applied Microbiology
Benjamin Brennan, Friedemann Weber, Richard Kormelink, Esther Schnettler, Michele Bouloy, Anna-Bella Failloux, Scott C. Weaver, John K. Fazakerley, Rennos Fragkoudis, Mark Harris, John N. Barr, Peter Palese, Adolfo Garcia-Sastre, Robert G. Dalzie, Bernadette M. Dutia, Anice C. Lowen, John Steel, Richard E. Randall, W. Paul Duprex, Charles M. Rice, Robert B. Tesh, Frederick A. Murphy, Hideki Ebihara, Pedro F. C. Vasconcelos, Marcio R. Nunes, Anthony R. Fooks, Geoffrey L. Smith, Ian Goodfellow, Hanu R. Pappu, Robert A. Lamb, Reay G. Paterson, Stephen Higgs, Dana L. Vanlandingham, Ralf G. Dietzgen, J. Stephen Lodmell, Stuart T. Nichol, Janet Daly, Diane E. Ullman, Alexander Plyusnin, Angelina Plyusnina, Stacey Efstathiou, Roger Hewson, Noel Tordo, Sara Cherry, Chris Boutell, Margaret J. Hosie, Pablo R. Murcia, James C. Neil, Massimo Palmarini, Arvind H. Patel, Brian J. Willett, Alain Kohl, John McLauchlan
JOURNAL OF GENERAL VIROLOGY
(2015)
Article
Virology
Mhairi C. Ferguson, Sirle Saul, Rennos Fragkoudis, Sabine Weisheit, Jonathan Cox, Adjanie Patabendige, Karen Sherwood, Mick Watson, Andres Merits, John K. Fazakerley
JOURNAL OF VIROLOGY
(2015)
Article
Virology
Sirle Saul, Mhairi Ferguson, Colette Cordonin, Rennos Fragkoudis, Margit Ool, Nele Tamberg, Karen Sherwood, John K. Fazakerley, Andres Merits
JOURNAL OF VIROLOGY
(2015)
Article
Parasitology
Sabine Weisheit, Margarita Villar, Hana Tykalova, Marina Popara, Julia Loecherbach, Mick Watson, Daniel Ruzek, Libor Grubhoffer, Jose de la Fuente, John K. Fazakerley, Lesley Bell-Sakyi
PARASITES & VECTORS
(2015)
Article
Immunology
Marieke Pingen, Steven R. Bryden, Emilie Pondeville, Esther Schnettler, Alain Kohl, Andres Merits, John K. Fazakerley, Gerard J. Graham, Clive S. McKimmie
Article
Virology
Rennos Fragkoudis, Catherine M. Dixon-Ballany, Adrian K. Zagrajek, Lukasz Kedzierski, John K. Fazakerley
Article
Entomology
Gerald Barry, Pilar Alberdi, Esther Schnettler, Sabine Weisheit, Alain Kohl, John K. Fazakerley, Lesley Bell-Sakyi
EXPERIMENTAL AND APPLIED ACAROLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Esther Schnettler, Claire L. Donald, Stacey Human, Mick Watson, Ricky W. C. Siu, Melanie McFarlane, John K. Fazakerley, Alain Kohl, Rennos Fragkoudis
JOURNAL OF GENERAL VIROLOGY
(2013)
Article
Virology
David Hallengard, Maria Kakoulidou, Aleksei Lulla, Beate M. Kuemmerer, Daniel X. Johansson, Margit Mutso, Valeria Lulla, John K. Fazakerley, Pierre Roques, Roger Le Grand, Andres Merits, Peter Liljestrom
JOURNAL OF VIROLOGY
(2014)
Article
Virology
David Hallengard, Fok-Moon Lum, Beate M. Kuemmerer, Aleksei Lulla, Valeria Lulla, Juan Garcia-Arriaza, John K. Fazakerley, Pierre Roques, Roger Le Grand, Andres Merits, Lisa F. P. Ng, Mariano Esteban, Peter Liljestrom
JOURNAL OF VIROLOGY
(2014)
Article
Biochemistry & Molecular Biology
Esther Schnettler, Hana Tykalova, Mick Watson, Mayuri Sharma, Mark G. Sterken, Darren J. Obbard, Samuel H. Lewis, Melanie McFarlane, Lesley Bell-Sakyi, Gerald Barry, Sabine Weisheit, Sonja M. Best, Richard J. Kuhn, Gorben P. Pijlman, Margo E. Chase-Topping, Ernest A. Gould, Libor Grubhoffer, John K. Fazakerley, Alain Kohl
NUCLEIC ACIDS RESEARCH
(2014)
Article
Infectious Diseases
Anna Moniuszko, Claudia Rueckert, M. Pilar Alberdi, Gerald Barry, Brian Stevenson, John K. Fazakerley, Alain Kohl, Lesley Bell-Sakyi
TICKS AND TICK-BORNE DISEASES
(2014)
Article
Microbiology
Samantha J. Griffiths, Manfred Koegl, Chris Boutell, Helen L. Zenner, Colin M. Crump, Francesca Pica, Orland Gonzalez, Caroline C. Friedel, Gerald Barry, Kim Martin, Marie H. Craigon, Rui Chen, Lakshmi N. Kaza, Even Fossum, John K. Fazakerley, Stacey Efstathiou, Antonio Volpi, Ralf Zimmer, Peter Ghazal, Juergen Haas
Article
Virology
Lukasz Kedzierski, Abigail Er Qi Tan, Isabelle Jia Hui Foo, Sandra E. Nicholson, John K. Fazakerley
Summary: SOCS5 plays a crucial role in regulating anti-viral immunity in the brain, influencing the critical balance between immunopathology and virus persistence, thus affecting the pathogenesis and clinical outcomes of neurotropic virus infections.
Review
Virology
Mathilde Laureti, Prasad N. Paradkar, John K. Fazakerley, Julio Rodriguez-Andres