Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Article
Cardiac & Cardiovascular Systems
Tom Alsaigh, Belinda A. Di Bartolo, Jocelyne Mulangala, Gemma A. Figtree, Nicholas J. Leeper
Summary: Peripheral arterial disease is a growing global problem, with a wide spectrum of clinical severity and significant economic impact. Despite advancements in therapies, there is a need for utilizing high-throughput discovery screens, novel translational models, and innovative trial designs. This review highlights recent advances in genomics and omics technologies, as well as new approaches to clinical studies for improving understanding and treatment of the disease.
CIRCULATION RESEARCH
(2021)
Review
Hematology
Levon M. Khachigian, Ramon L. Varcoe, Tuisku Suoranta, Nihay Laham-Karam, Seppo Yla-Herttuala
Summary: Peripheral artery disease (PAD), caused by occlusive atherosclerosis, is a vascular disorder that leads to impaired blood flow in the lower extremities. With over 200 million affected individuals globally, PAD is an increasing global health problem due to aging population and rising diabetes incidence. Gene therapy offers potential to improve blood flow in PAD patients through angiogenesis and arteriogenesis. This article discusses gene therapy approaches for both intermittent claudication and critical limb ischemia in the context of PAD, as well as the use of adeno-associated virus-based strategies to deliver various mediators.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Gauri Arolkar, Sneha K. Kumar, Hanjay Wang, Karen M. Gonzalez, Suraj Kumar, Bhavnesh Bishnoi, Pamela Rios E. Coronado, Y. Joseph Woo, Kristy Red-Horse, Soumyashree Das
Summary: In this study, researchers found that neonatal artery endothelial cells have the ability to regenerate and develop into functional collateral arteries in ischemic regions of the heart. However, adult artery endothelial cells lack this regenerative ability due to their limited capacity for dedifferentiation and proliferation. These findings are significant for understanding the mechanisms of cardiac regeneration and could lead to the development of related therapeutic strategies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emily R. Mahoney, Logan Dumitrescu, Annah M. Moore, Francis E. Cambronero, Philip L. De Jager, Mary Ellen Koran, Vladislav A. Petyuk, Rena A. S. Robinson, Sandeep Goyal, Julie A. Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman
Summary: The study revealed that the VEGF gene family plays a complex role in neuroprotection and is associated with cognitive performance, cognitive decline, and Alzheimer's disease pathology.
MOLECULAR PSYCHIATRY
(2021)
Review
Endocrinology & Metabolism
Rui Ding, Shicong Zhu, Xiaoyan Zhao, Rensong Yue
Summary: This meta-analysis evaluated the relationship between circulating levels of VEGFs and diabetic peripheral neuropathy (DPN). The results showed that VEGF levels were significantly increased in DPN patients compared to diabetic patients without DPN and healthy individuals. However, there was no evidence to support the correlation between VEGF levels and the risk of DPN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Haoting Zhan, Haolong Li, Chenxi Liu, Linlin Cheng, Songxin Yan, Yongzhe Li
Summary: Circulating VEGF levels are associated with autoimmune diseases and may predict disease manifestations and activity in patients, indicating potential therapeutic implications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Pabon, Susan Cheng, S. Elissa Altin, Sanjum S. Sethi, Michael D. Nelson, Kerrie L. Moreau, Naomi Hamburg, Connie N. Hess
Summary: Peripheral artery disease (PAD) has similar or higher prevalence in women compared to men, but there are sex differences in the mechanisms and clinical manifestations. Despite available treatments, there are still sex differences in treatment and outcomes.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Bin Jiang, Xinlong Wang, Nancy Rivera-Bolanos, Guillermo A. Ameer
Summary: Peripheral artery disease (PAD) is a prevalent cardiovascular disease that can lead to limb loss. This study aimed to establish an autologous cell source for vascular regeneration in PAD. The induced pluripotent stem cell (iPSC) approach successfully generated patient-specific vascular endothelial cells (ECs) in all PAD patients, while the endothelial progenitor cell (EPC) approach did not yield any colony-forming ECs. The patient-derived iPSC-ECs expressed endothelial markers and exhibited endothelial functions. Pharmacological treatment with resveratrol showed patient-specific responses in cell viability and VCAM-1 expression.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Mei You, Yushuang Liu, Bowen Wang, Li Li, Hexuan Zhang, Hongbo He, Qing Zhou, Tingbing Cao, Lijuan Wang, Zhigang Zhao, Zhiming Zhu, Peng Gao, Zhencheng Yan
Summary: Elevated circulating levels of asprosin are identified as an independent risk factor for lower extremity PAD and could serve as a diagnostic marker. Mechanistically, asprosin directly induces EndMT that contributes to vascular injury via activation of the TGF-beta signaling pathway.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Acoustics
Lei Xu, Ting Fu, Yu Wang, Ningning Ji
Summary: This study investigated the correlation between miR-296 and VEGF-B expression levels in peripheral blood and the degree of coronary artery stenosis (CAS) in CHD patients. The findings suggest that the combination of low expression of miR-296 and high expression of VEGF-B can predict the degree of CAS in CHD patients.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Review
Medicine, General & Internal
A. Blum
Summary: Women have a clinical advantage in atherosclerotic cardiovascular disease (CVD) compared to men, but this advantage diminishes with aging. By their seventh decade, women have an equal risk of developing CVD as men of the same age. Various theories have been proposed to explain this gender difference, including hormonal and cardiovascular system differences. This review aims to review and discuss these different mechanisms.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Martine Paquette, Sophie Bernard, Alexis Baass
Summary: This study found that patients with DBL have a significantly higher risk of ASCVD and PVD compared to normolipidemic controls, as well as a higher risk of PVD compared to patients with FH. Adequate screening for DBL is vital to improve the clinical care and prevent the development of ASCVD in these patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Surgery
Soo J. Rhee-Moore, Brian G. DeRubertis, Russell C. Lam, Robert L. Hynecek, Larisse Lee, James F. McKinsey, Nicholas J. Morrissey, John Karwowski, Leila Mureebe, K. Craig Kent, Peter L. Faries
ANNALS OF VASCULAR SURGERY
(2008)
Review
Surgery
Ruth L. Bush, Leila Mureebe, William T. Bohannon, Robert B. Rutherford
JOURNAL OF SURGICAL RESEARCH
(2008)
Article
Surgery
Leila Mureebe, Natalia Egorova, Jeannine K. Giacovelli, Annetine Gelijns, K. Craig Kent, James F. McKinsey
JOURNAL OF VASCULAR SURGERY
(2008)
Article
Surgery
Leila Mureebe, Joseph A. Graham, Ruth L. Bush, Donald Silver
ANNALS OF VASCULAR SURGERY
(2007)
Article
Peripheral Vascular Disease
Leila Mureebe
Article
Peripheral Vascular Disease
Leila Mureebe, James F. McKinsey
Article
Surgery
Evan J. Ryer, Susan M. Trocciola, Brian DeRubertis, Russel Lam, Robert L. Hynecek, John Karwowski, Harry L. Bush, Leila Mureebe, James F. McKinsey, Nicholas J. Morrissey, K. Craig Kent, Peter L. Faries
ANNALS OF VASCULAR SURGERY
(2006)
Meeting Abstract
Surgery
SM Trocciola, EJ Ryer, SC Lin, RA Chaer, B DeRubertis, M Pierce, P Christos, L Mureebe, PL Faries, KC Kent
JOURNAL OF ENDOVASCULAR THERAPY
(2006)
Article
Surgery
SC Lin, SM Trocciola, J Rhee, R Dayal, R Chaer, NJ Morrissey, L Mureebe, JF McKinsey, KC Kent, PL Faries
ANNALS OF VASCULAR SURGERY
(2005)
Letter
Surgery
RL Bush, PH Lin, L Mureebe, W Zhou, EK Peden, AB Lurnsden
JOURNAL OF ENDOVASCULAR THERAPY
(2005)
Article
Anesthesiology
PC Dyke, P Russo, L Mureebe, J Russo, JD Tobias
PEDIATRIC ANESTHESIA
(2005)
Article
Surgery
RL Bush, PH Lin, JT Bates, L Mureebe, W Zhou, AB Lumsden
JOURNAL OF VASCULAR SURGERY
(2004)
Article
Surgery
L Mureebe, RD Coats, WR Silliman, TA Shuster, WK Nichols, D Silver
Article
Surgery
L Mureebe, SE Turnquist, D Silver
ANNALS OF VASCULAR SURGERY
(2004)