Review
Rheumatology
Shazeen Ayub, Jaspreet Kaur, Michelle Hui, Shima Espahbodi, Michelle Hall, Michael Doherty, Weiya Zhang
Summary: The study found that multiple intra-articular corticosteroid injections were no more effective than placebo for osteoarthritis pain relief. Some experiments suggested that such injections may worsen the structural progression of osteoarthritis. Further research is needed to assess the efficacy and safety of multiple intra-articular corticosteroid injections.
Review
Rehabilitation
Zhen Xu, Yidi Wang, Yue Zhang, Yifan Lu, Yuhong Wen
Summary: Aquatic exercise has significant benefits in terms of pain, stiffness, and physical function for patients with knee osteoarthritis, particularly immediately and within three months post-intervention. The effects of aquatic exercise are comparable to land-based exercise. There were no serious adverse events associated with aquatic exercise.
CLINICAL REHABILITATION
(2023)
Article
Food Science & Technology
Hye Jun Lee, Do Un Kim, Choon Ok Kim
Summary: The study suggests that low-molecular-weight collagen peptide can reduce knee pain in patients with osteoarthritis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Orthopedics
Chun-Ru Lin, Sung Huang Laurent Tsai, Ko-Yen Huang, Po-An Tsai, Hsuan Chou, Shu-Hao Chang
Summary: Collagen peptides have been shown to provide significant pain relief for patients with knee osteoarthritis compared to placebo, with no significant difference in adverse events. Further well-designed randomized controlled trials are needed to confirm these findings.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Medicine, General & Internal
Guangting Li, Zhongming Zhang, Yingying Ye, Huiping Li, Hanwen Luo, Kaijiang Tang, Yongrong Lai
Summary: This study systematically reviewed the efficacy, safety, and residual effectiveness of diacerein in the treatment of knee osteoarthritis. The results showed that diacerein did not significantly differ from placebo in reducing joint pain and improving function. However, compared to placebo, diacerein treatment showed improvement in visual analogue scale score and physical function score. There was also a significant residual effect of diacerein treatment after discontinuation. Although diacerein was associated with an increased risk of diarrhea, the adverse event was mostly tolerable.
Review
Plant Sciences
Qing Wang, Guihua Xu, Yongqi Liang, Yue Xu, Yuan Zhu, Hui Ye
Summary: This study systematically evaluated the effectiveness and safety of oral Chinese herbal medicine (CHM) in the treatment of knee osteoarthritis (KOA). The results showed that CHM was more effective than placebo and Western medicine in the treatment of KOA. Additionally, the combination of CHM and Western medicine was superior to Western medicine alone. However, due to biases in the included studies and the need for further research on the effective components of Chinese medicine, a definitive conclusion on the efficacy of traditional CHM in treating KOA cannot be drawn and requires confirmation through high-quality clinical trials.
Review
Health Care Sciences & Services
Yong-Qiang Wu, Yi Long, Wei-Jie Peng, Cheng Gong, Yue-Quan Liu, Xu-Miao Peng, Yan-Biao Zhong, Yun Luo, Mao -Yuan Wang
Summary: Telerehabilitation can improve the symptoms and quality of life of fibromyalgia patients. However, the safety of telerehabilitation remains uncertain due to the lack of sufficient evidence. More rigorously designed trials are needed in the future to verify the safety and efficacy of telerehabilitation in fibromyalgia.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Plant Sciences
Leonard Ho, Claire C. W. Zhong, Charlene H. L. Wong, Justin C. Y. Wu, Karina K. H. Chan, Irene X. Y. Wu, Ting Hung Leung, Vincent C. H. Chung
Summary: This study evaluated the comparative effectiveness of herbal medicine formulae for functional dyspepsia through a network meta-analysis. Findings suggest that Xiao Yao Pill and Modified Ban Xia Xie Xin Decoction may have beneficial effects in alleviating global symptoms, with no serious adverse events reported. Further trials are needed to assess the comparative effectiveness of these formulae.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Veterinary Sciences
Chanthawat Patikorn, Osot Nerapusee, Kumpanart Soontornvipart, Kanta Lawonyawut, Kachapong Musikpodok, Kanisorn Waleethanaphan, Puree Anantachoti
Summary: CBD is considered safe for treating canine OA, but the evidence for its clinical efficacy is uncertain. Further high-quality clinical trials are needed.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Nutrition & Dietetics
Georgios Konstantis, Stylianos Efstathiou, Chryssa Pourzitaki, Elisavet Kitsikidou, Georgios Germanidis, Michail Chourdakis
Summary: This meta-analysis evaluated the efficacy and safety of probiotics in IBS-patients. The results showed a significant reduction in abdominal pain and bloating, but no improvement in other parameters. Larger randomized controlled trials are needed to confirm these findings and further investigate the use of specific probiotic strains.
CLINICAL NUTRITION
(2023)
Article
Plant Sciences
Jinlong Zhao, Weiyi Yang, Guihong Liang, Minghui Luo, Jianke Pan, Jun Liu, Lingfeng Zeng
Summary: The Jinwu Gutong capsule showed good clinical efficacy and safety in treating knee osteoarthritis, and could significantly improve the treatment efficacy when combined with NSAIDs, hyaluronic acid, or glucosamine.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Orthopedics
Jian Liu, Ting Wang, Zhen-Hua Zhu
Summary: This meta-analysis demonstrated that radiofrequency (RF) treatment is effective and safe in relieving knee pain and improving knee function in patients with knee osteoarthritis (OA).
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Rheumatology
Pascal Richette, Augustin Latourte, Jeremie Sellam, Daniel Wendling, Muriel Piperno, Philippe Goupille, Yves-Marie Pers, Florent Eymard, Sebastien Ottaviani, Paul Ornetti, Rene-Marc Flipo, Bruno Fautrel, Olivier Peyr, Jean Pierre Bertola, Eric Vicaut, Xavier Chevalier
Summary: The study found that tocilizumab was not more effective than placebo in relieving pain in patients with hand osteoarthritis. Apart from the primary endpoint, there were no significant differences in secondary outcomes between the tocilizumab group and the placebo group.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Medicine, General & Internal
Aleksander Chaibi, Knut Stavem, Michael Bjorn Russell
Summary: Spinal manipulative therapy (SMT) is effective for acute neck pain, with significant improvement compared to medication one day post-treatment. Minor transient adverse events were reported, but no serious adverse events occurred.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Ahmed Almradi, Rocio Sedano, Malcolm Hogan, G. Y. Zou, John K. MacDonald, Claire E. Parker, Jurij Hanzel, Eileen Crowley, Siddharth Singh, Geert D'Haens, William J. Sandborn, Brian G. Feagan, Christopher Ma, Vipul Jairath
Summary: This study quantifies the placebo rates in Crohn's disease trials and identifies factors influencing these rates. The findings suggest that placebo remission and response rates vary based on the trial phase, endpoint assessed, and induction or maintenance design.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Geriatrics & Gerontology
Hui Wen Quek, Christopher Etherton-Beer, Amy Page, Andrew J. McLachlan, Sarita Y. Lo, Vasi Naganathan, Leanne Kearney, Sarah N. Hilmer, Tracy Comans, Derelie Mangin, Richard Lindley, Kathleen Potter
Summary: This study aimed to investigate pharmacist deprescribing recommendations for residents in aged care facilities, the acceptance of these recommendations by doctors, and the actual implementation of the accepted recommendations at 12-month follow-up. The results showed that 77% of deprescribing recommendations were accepted by doctors, and 74% of the accepted recommendations were successfully implemented. The most common reason for deprescribing was medication no longer being needed. Pharmacist-led deprescribing recommendations based on an algorithm-based medication review are acceptable to doctors and can significantly reduce inappropriate medication use in aged care facilities.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Review
Pharmacology & Pharmacy
Prue A. Anderson, Andrew J. McLachlan, Christina Abdel Shaheed, Danijela Gnjidic, Rowena Ivers, Stephanie Mathieson
Summary: This scoping review aimed to assess the extent and nature of gabapentinoid deprescribing interventions in adults. The study found that interventions such as dose-reducing protocols, education, and pharmacological-based approaches can lead to a decrease in gabapentinoid use and prescribing rates. However, there is a lack of evidence on long-term effects and patient-focused psychological interventions.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sarah N. Hilmer, Sarita Lo, Patrick J. Kelly, Rosalie Viney, Fiona M. Blyth, David G. Le Couteur, Andrew J. McLachlan, Sheena Arora, Lutfun Hossain, Danijela Gnjidic
Summary: This study comprehensively investigates the prescribing practices for hospitalized older people, focusing on polypharmacy, potentially inappropriate medications (PIMs) based on Beers criteria, and cumulative exposure to anticholinergic and sedative medications using the Drug Burden Index (DBI). The study aims to quantify the exposure to these measures on admission, analyze changes between admission and discharge, and assess the associations with adverse outcomes and medication costs. The findings show an increase in the number of medications during hospitalization and slight reductions in PIMs and DBI, with varying associations with adverse outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Emergency Medicine
Qiuzhe Chen, Chris G. Maher, Eileen Rogan, Gustavo Machado
Summary: This study compared care delivery for low back pain in Australian EDs between culturally and linguistically diverse (CALD) and non-CALD patients. The results showed that CALD patients were more likely to receive imaging and be admitted. The quality of care for low back pain in CALD patients needs special attention and improvement.
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Emergency Medicine
Caitlin M. P. Jones, Danielle Coombs, Chung-Wei Christine Lin, Adrian Traeger, Qiang Li, Christina Abdel Shaheed, Sweekriti Sharma, Chris G. Maher, Gustavo C. Machado
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Clinical Neurology
Carolina Gassen Fritsch, Paulo H. Ferreira, Thomas Lung, Andrew J. McLachlan, Manuela L. Ferreira
Summary: A cross-sectional analysis was conducted to determine the smallest change in function and the association with patient-related factors in a self-management intervention for low back pain. The results showed that, on average, a 9.4-point improvement in function was considered worthwhile by patients with LBP. Only the severity of baseline function was significantly associated with the smallest worthwhile change estimate.
EUROPEAN SPINE JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
Christopher G. Maher, Aline Archambeau, Rachelle Buchbinder, Simon D. French, Julia Morphet, Michael J. Yelland, Peter O'Sullivan, Marie Pirotta, Michael J. Yelland, Leo Zeller, Nivene Saad, Elizabeth Marles, Alice L. Bhasale, Christina Lane
INTERNAL MEDICINE JOURNAL
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Christopher G. Maher, Aline Archambeau, Rachelle Buchbinder, Simon D. French, Julie Morphet, Michael K. Nicholas, Peter O'Sullivan, Marie Pirotta, Michael J. Yelland, Leo Zeller, Nivene Saad, Elizabeth Marles, Alice L. Bhasale, Christina Lane
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2023)
Editorial Material
Orthopedics
Christina Abdel Shaheed, Stephanie Mathieson, Ross Wilson, Ann-Mason Furmage, Christopher G. Maher
JOURNAL OF PHYSIOTHERAPY
(2023)
Article
Medicine, General & Internal
Jan F. L. Gan, Marnee J. McKay, Caitlin M. P. Jones, Ian A. Harris, Kirsten McCaffery, Rachel Thompson, Tammy C. Hoffmann, Sam Adie, Christopher G. Maher, Joshua R. Zadro
Summary: This study developed a patient decision aid to portray the benefits and harms of non-surgical management and surgery for Achilles tendon ruptures, and conducted user-testing. The results showed that the decision aid was acceptable to both patients and health professionals. However, there were differing views among health professionals on details such as Achilles tendon retraction distance, factors modifying harm risks, treatment protocols, and evidence on benefits and harms.
Article
Medicine, General & Internal
Alla Melman, Harrison J. Lord, Danielle Coombs, Joshua Zadro, Christopher G. Maher, Gustavo C. Machado
Summary: This is the first systematic review with meta-analysis summarizing the global prevalence of hospital admissions and hospital length of stay for low back pain. The study found high heterogeneity in admission rates from the emergency department, with a median percentage of all hospital admissions due to low back pain being 0.9%. The median hospital length of stay for low back pain was 6.2 days. The overall quality of evidence was moderate.
Article
Medicine, General & Internal
Joshua R. Zadro, Zoe A. Michaleff, Mary O'Keeffe, Giovanni E. Ferreira, Adrian C. Traeger, Andrew R. Gamble, Frederick Afeaki, Yaozhuo Li, Erya Wen, Jiawen Yao, Kejie Zhu, Richard Page, Ian A. Harris, Christopher G. Maher
Summary: The study analyzed the qualitative data collected from a randomized experiment to explore how people perceive different advice for rotator cuff disease. It found that guideline-based advice evoked feelings of reassurance and trust in expertise, while treatment recommendation evoked feelings of needing treatment and psychological distress.
Article
Emergency Medicine
Katie de Luca, Andrew J. McLachlan, Chris G. Maher, Gustavo C. C. Machado
Summary: This study aimed to investigate the management of older adults with lumbar spine conditions in emergency departments, as well as predictors of healthcare utilization in this population. Findings indicated that over one-third of older adults presenting to the emergency department were diagnosed with non-specific low back pain, and the majority were females. They received extensive imaging and laboratory tests, with opioid analgesics being the most commonly administered pain medication. The cost of care per presentation was high and a substantial proportion of patients were admitted to hospital.
BMC EMERGENCY MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Deborah H. Greenbaum, Andrew J. McLachlan, Rebecca H. Roubin, Rebekah Moles, Betty B. Chaar
Summary: This study investigated the knowledge and skills of pharmacists in Sydney, Australia, in preventing the use of prohibited medications by athletes. The findings revealed that although most pharmacists had the skills to provide assistance on prohibited substances, they lacked comprehensive knowledge and resources in delivering care to prevent harm and protect athletes from anti-doping violations. There is a need for additional education in sport-related pharmacy and the incorporation of this field into current practice guidelines to ensure pharmacists can fulfill their duty of care and athletes can benefit from their medicines-related advice.
INTERNATIONAL JOURNAL OF PHARMACY PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Josephine A. Adattini, Jeffry Adiwidjaja, Annette S. Gross, Andrew J. McLachlan
Summary: This study aimed to predict imatinib steady-state plasma exposure in chronic myeloid leukemia (CML) patients using physiologically based pharmacokinetic (PBPK) modeling and simulation, and investigate variability in outcomes. A validated imatinib PBPK model (Simcyp Simulator) was used to predict imatinib exposure for CML patients from a real-world observational study. Differences in imatinib exposure were evaluated based on clinical outcomes and sensitivity analyses explored the influence of patient characteristics and drug interactions. The simulation results identified various patient and medication-related factors contributing to the inter-individual variability in imatinib exposure.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)