Article
Rheumatology
Siri Lillegraven, Nina Paulshus Sundlisaeter, Anna-Birgitte Aga, Joseph Sexton, Inge Christoffer Olsen, Ase Stavland Lexberg, Tor Magne Madland, Hallvard Fremstad, Christian A. Hoili, Gunnstein Bakland, Cristina Spada, Hilde Haukeland, Inger Myrnes Hansen, Ellen Moholt, Till Uhlig, Daniel H. Solomon, Desiree Van der Heijde, Tore K. Kvien, Espen A. Haavardsholm
Summary: This study aimed to assess the effect of tapering tumor necrosis factor inhibitor (TNFi) to withdrawal compared with stable treatment on the risk of disease activity flares in patients with rheumatoid arthritis (RA) in remission for more than 1 year. The results showed that in the tapering TNFi group, 63% experienced a flare during 12 months, compared to 5% in the stable TNFi group. Therefore, tapering TNFi to discontinuation is not non-inferior to continued stable treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Shivshankar Thanigaimani, Muhammad Ibrahim, Jonathan Golledge
Summary: This review examined the potential role of biologic disease-modifying anti-rheumatic drugs (bDMARDs) as repurposed drugs for treating abdominal aortic aneurysms (AAA). Findings from animal models and human tissue samples suggest that tumor necrosis factor-alpha, interleukin-6, and IL-17 are implicated in the pathogenesis of AAA.
Article
Rheumatology
Yu-Jih Su, Hui-Ming Chen, Tien-Ming Chan, Tien-Tsai Cheng, Shan-Fu Yu, Jia-Feng Chen, Chun-Yu Lin, Chung-Yuan Hsu
Summary: This study aimed to investigate whether patients using disease-modifying anti-rheumatic drugs (DMARDs) may have different levels of risk for diabetes and to analyze other risk factors for diabetes. The results showed that certain DMARDs can reduce the risk of diabetes.
Article
Rheumatology
Stefania Spila Alegiani, Salvatore Crisafulli, Paolo Giorgi Rossi, Pamela Mancuso, Carlo Salvarani, Fabiola Atzeni, Rosa Gini, Ursula Kirchmayer, Valeria Belleudi, Peter Konstantin Kurotschka, Olivia Leoni, Monica Ludergnani, Eliana Ferroni, Susanna Baracco, Marco Massari, Gianluca Trifiro
Summary: The study found that the use of rheumatic drugs does not reduce the risk of COVID-19 hospitalization and mortality, and the use of other rheumatic drugs may increase the risk when compared to non-use.
Review
Medicine, Research & Experimental
George Robinson, Ines Pineda-Torra, Coziana Ciurtin, Elizabeth C. Jury
Summary: Conventional therapies for autoimmune rheumatic diseases can have unpredictable effects on cell metabolism, including lipid metabolism. New therapeutic technologies offer more targeted approaches to reduce inflammation and prevent off-target metabolic consequences. Lipid metabolism plays a key role in inflammation and the mechanisms of action of AIRD therapeutics. Co-therapies targeting lipid metabolism have the potential to reduce immunometabolic complications and cardiovascular disease risk in AIRD patients.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Rheumatology
Celia A. J. Michielsens, Nathan den Broeder, Frank H. J. van den Hoogen, Elien A. M. Mahler, Steven Teerenstra, Desiree van der Heijde, Lise M. Verhoef, Alfons A. den Broeder
Summary: In patients with PsA and axSpA, a T2T TNFi strategy with tapering attempt is non-inferior to a T2T strategy without tapering in terms of the proportion of patients still in low disease activity (LDA) at 12 months, and results in a substantial reduction of TNFi use.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Pharmacology & Pharmacy
Ronaldo Jose Faria, Francisca Janiclecia Rezende Cordeiro, Jessica Barreto Ribeiro dos Santos, Juliana Alvares-Teodoro, Augusto Afonso Guerra Junior, Francisco de Assis Acurcio, Michael Ruberson Ribeiro da Silva
Summary: This study compared the use of conventional synthetic disease-modifying antirheumatic drugs in the treatment of psoriatic arthritis. The results showed that methotrexate was the most frequently used drug, with lower cost and slightly lower persistence, making it the drug with the best cost per response ratio.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Takuya Harada, Hiromi Iwasaki, Tsuyoshi Muta, Shingo Urata, Aiko Sakamoto, Kentaro Kohno, Ken Takase, Tomoya Miyamura, Takuya Sawabe, Hideki Asaoku, Kensuke Oryoji, Tomoaki Fujisaki, Yasuo Mori, Goichi Yoshimoto, Masahiro Ayano, Hiroki Mitoma, Toshihiro Miyamoto, Hiroaki Niiro, Hidetaka Yamamoto, Yumi Oshiro, Hiroaki Miyoshi, Koichi Ohshima, Morishige Takeshita, Koichi Akashi, Koji Kato
Summary: The study evaluated the clinical outcomes of MTX-LPD patients and found that the pathological subtype of lymphoma could predict the clinical outcome. Patients with polymorphic-type LPD had better event-free survival compared to other subtypes. Use of TNF-alpha inhibitors was associated with higher non-relapse mortality in DLBCL patients, while RA patients previously treated with JAK inhibitors more commonly required chemotherapy, indicating disease aggressiveness.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Shivshankar Thanigaimani, James Phie, Smriti Krishna, Joseph Moxon, Jonathan Golledge
Summary: The study found that DMARDs did not have a significant impact on preventing cardiovascular events. Risk of bias in the existing trials was high, and more trials are needed to draw firm conclusions.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Yu-Hao Lee, Shih-Wei Huang, Chih-Kuang Chen, Jia-Pei Hong, Yi-Wen Chen, Hui-Wen Lin
Summary: This study investigated the risk of dementia in axSpA patients and the role of csDMARDs in reducing the risk. The results showed that axSpA patients had a higher risk of vascular dementia, but the use of csDMARDs did not significantly affect the risk of dementia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Rheumatology
Marcia A. Friedman, Jeffrey R. Curtis, Kevin L. Winthrop
Summary: Patients with rheumatic diseases are at increased risk of infectious complications, and disease-modifying antirheumatic drugs can reduce the immunogenicity of common vaccines. Different medications have varying impacts on vaccine immunogenicity, with rituximab having the most substantial effect and Janus kinase and tumour necrosis factor inhibitors decreasing antibody titres. Emerging data suggest that the effect of these medications on the SARS-CoV-2 vaccine immunogenicity is similar to other vaccines, but more research is needed.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Michalis P. Migkos, Evripidis Kaltsonoudis, Eleftherios Pelechas, Vassiliki Drossou, Panagiota G. Karagianni, Athanasios Kavvadias, Paraskevi V. Voulgari, Alexandros A. Drosos
Summary: A study on patients with inflammatory arthritis treated with medication found that those who contracted COVID-19 had mild symptoms, mainly presenting with systemic manifestations and sore throat. Most patients had a favorable disease course.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Reinier C. A. van Linschoten, Fenna M. Jansen, Renske W. M. Pauwels, Lisa J. T. Smits, Femke Atsma, Wietske Kievit, Dirk J. de Jong, Annemarie C. de Vries, Paul J. Boekema, Rachel L. West, Alexander G. L. Bodelier, Ingrid A. M. Gisbertz, Frank H. J. Wolfhagen, Tessa E. H. Romkens, Maurice W. M. D. Lutgens, Adriaan A. van Bodegraven, Bas Oldenburg, Marieke J. Pierik, Maurice G. V. M. Russel, Nanne K. de Boer, Rosalie C. Mallant-Hent, Pieter C. J. ter Borg, Andrea E. van der Meulen-de Jong, Jeroen M. Jansen, Sita Jansen, Adrianus C. I. T. L. Tan, C. Janneke van der Woude, Frank Hoentjen
Summary: The study aimed to assess the clinical outcomes of increased adalimumab dose intervals versus conventional dosing in patients with stable remission of Crohn's disease. The results showed that increasing the adalimumab dose intervals to 3 weeks and further to 4 weeks was non-inferior for maintaining stable remission, and this approach reduced the risk of infections and healthcare costs.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Rheumatology
Andra-Rodica Balanescu, Gustavo Citera, Virginia Pascual-Ramos, Deepak L. Bhatt, Carol A. Connell, David Gold, All-Shine Chen, Gosford Sawyerr, Andrea B. Shapiro, Janet E. Pope, Hendrik Schulze-Koops
Summary: This study aimed to characterize infections in patients with rheumatoid arthritis (RA) receiving different treatment regimens. The results showed that tofacitinib had a higher risk of infections compared to tumor necrosis factor inhibitors (TNFi). These findings may provide insights for future treatment decisions.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Ailsa Hart, Peter Bossuyt, Millie Long, Matthieu Allez, Pascal Juillerat, Alessandro Armuzzi, Edward Loftus, Elham Ostad-Saffari, Astrid Scalori, Young S. Oh, Swati Tole, Akiko Chai, Jennifer Pulley, Stuart Lacey, William J. Sandborn
Summary: This study evaluated the efficacy and safety of etrolizumab in patients with moderately to severely active ulcerative colitis who had been previously treated with anti-TNF agents. The results showed that etrolizumab significantly improved remission rates at week 14 compared to placebo, but there was no significant difference between the two groups in remission rates at week 66.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Psychology, Clinical
Craig Morgan, Paola Dazzan, Julia Lappin, Margaret Heslin, Kim Donoghue, Paul Fearon, Peter B. Jones, Robin M. Murray, Gillian A. Doody, Ulrich Reininghaus
Summary: By analyzing data from the AESOP-10 study, four specific classes of individuals with different symptom trajectories of psychotic disorders were identified, indicating that the current approach to categorizing the course of psychotic disorders may misclassify patients.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Joanne B. Newbury, Robert Stewart, Helen L. Fisher, Sean Beevers, David Dajnak, Matthew Broadbent, Megan Pritchard, Narushige Shiode, Margaret Heslin, Ryan Hammoud, Matthew Hotopf, Stephani L. Hatch, Ian S. Mudway, Ioannis Bakolis
Summary: Research indicates that residential air pollution exposure is associated with increased mental health service use among individuals recently diagnosed with psychotic and mood disorders, suggesting the potential impact of air pollution on illness severity and relapse.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Louise M. Howard, Kylee Trevillion, Laura Potts, Margaret Heslin, Andrew Pickles, Sarah Byford, Lauren E. Carson, Clare Dolman, Stacey Jennings, Sonia Johnson, Ian Jones, Rebecca McDonald, Susan Pawlby, Claire Powell, Gertrude Seneviratne, Rebekah Shallcross, Nicky Stanley, Angelika Wieck, Kathryn M. Abel
Summary: This study found no significant differences in readmission rates between mother and baby units (MBUs) and non-MBU acute care for perinatal mental illness. However, women accessing MBUs reported higher satisfaction with services.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Emmanuelle Peters, Amy Hardy, Robert Dudley, Filippo Varese, Kathryn Greenwood, Craig Steel, Richard Emsley, Nadine Keen, Samantha Bowe, Sarah Swan, Raphael Underwood, Eleanor Longden, Sarah Byford, Laura Potts, Margaret Heslin, Nick Grey, Doug Turkington, David Fowler, Elizabeth Kuipers, Anthony Morrison
Summary: This study aims to evaluate the clinical effectiveness of TF-CBTp on post-traumatic stress symptoms in people with psychosis. It also seeks to compare cost-effectiveness, impact on other meaningful outcomes, therapy endurance, and therapy acceptability.
Article
Health Care Sciences & Services
Margaret Heslin, Huajie Jin, Kylee Trevillion, Xiaoxiao Ling, Selina Nath, Barbara Barrett, Jill Demilew, Elizabeth G. Ryan, Sheila O'Connor, Polly Sands, Jeannette Milgrom, Debra Bick, Nicky Stanley, Myra S. Hunter, Louise M. Howard, Sarah Byford
Summary: This study investigates the cost-effectiveness of screening tools for detecting depression in early pregnancy and finds that all three screening approaches have a higher probability of being cost-effective compared to no screening option.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Psychology, Clinical
Jenny Yiend, Charlene L. M. Lam, Nora Schmidt, Bryony Crane, Margaret Heslin, Thomas Kabir, Philip McGuire, Christopher Meek, Elias Mouchlianitis, Emmanuelle Peters, Daniel Stahl, Antonella Trotta, Sukhwinder Shergill
Summary: This study investigated the feasibility and efficacy of Cognitive Bias Modification for paranoia (CBM-pa) in patients with paranoia. The results showed that CBM-pa was effective in reducing interpretation bias, improving paranoia symptoms, and reducing levels of depressed and anxious mood. The study provides a foundation for conducting a fully powered randomized controlled trial.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Leonie Lee-Carbon, Selina Nath, Kylee Trevillion, Sarah Byford, Louise M. Howard, Fiona L. Challacombe, Margaret Heslin
Summary: Only one-third of women diagnosed with a mental disorder during their antenatal appointments had any contact with mental health services during pregnancy or up to 3 months postpartum. Further research is needed to understand the potential barriers to accessing professional mental health care for perinatal women.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychology, Clinical
Anna C. Morris, Zina Ibrahim, Margaret Heslin, Omer S. Moghraby, Argyris Stringaris, Ian M. Grant, Lukasz Zalewski, Megan Pritchard, Robert Stewart, Matthew Hotopf, Andrew Pickles, Richard J. B. Dobson, Emily Simonoff, Johnny Downs
Summary: This study assesses the potential of the MHE system in improving the completion of PROMs. The results indicate that the use of MHE significantly increases the completion rates of questionnaires compared to paper-based methods. Caregivers express satisfaction with the MHE system and highlight its numerous benefits.
CHILD AND ADOLESCENT MENTAL HEALTH
(2023)
Review
Endocrinology & Metabolism
Cathy Breen, Jean O'Connell, Justin Geoghegan, Donal O'Shea, Susie Birney, Louise Tully, Karen Gaynor, Mark O'Kelly, Grace O'Malley, Clare O'Donovan, Oonagh Lyons, Mary Flynn, Suzanne Allen, Niamh Arthurs, Sarah Browne, Molly Byrne, Shauna Callaghan, Chris Collins, Aoife Courtney, Michael Crotty, Ciara Donohue, Caroline Donovan, Colin Dunlevy, Diarmuid Duggan, Naomi Fearon, Francis Finucane, Ita Fitzgerald, Siobhan Foy, John Garvey, Irene Gibson, Liam Glynn, Edward Gregg, Anne Griffin, Janas M. Harrington, Caroline Heary, Helen Heneghan, Andrew Hogan, Mary Hynes, Claire Kearney, Dervla Kelly, Karl Neff, Carel W. le Roux, Sean Manning, Fionnuala McAuliffe, Susan Moore, Niamh Moran, Maura Murphy, Celine Murrin, Sarah M. O'Brien, Caitriona O'Donnell, Sarah O'Dwyer, Cara O'Grada, Emer O'Malley, Orlaith O'Reilly, Sharleen O'Reilly, Olivia Porter, Helen M. Roche, Amanda Rhynehart, Leona Ryan, Suzanne Seery, Corina Soare, Ferrah Shaamile, Abigail Walsh, Catherine Woods, Conor Woods, Ruth Yoder
Summary: This clinical practice guideline for obesity management in adults in Ireland emphasizes the importance of improving patient-centered health outcomes, functional outcomes, and social and economic participation. It also calls for the elimination of bias and stigma towards people living with obesity, and advocates for evidence-informed care, including various interventions and surgical treatments. Additionally, the guideline suggests addressing health inequalities by including obesity in chronic disease management programs and ensuring equal access to treatment regardless of ability to pay.
Article
Obstetrics & Gynecology
Camilla Forbes, Hayley Alderson, Jill Domoney, Alexandra Papamichail, Vashti Berry, Ruth McGovern, Nick Sevdalis, Judith Rankin, Mary Newburn, Andy Healey, Abigail Easter, Margaret Heslin, Gene Feder, Kristian Hudson, Claire A. Wilson, G. J. Melendez-Torres, Louise M. Howard, Kylee Trevillion
Summary: This study aimed to investigate the implementation of healthcare-based Independent Domestic Violence Advisors (hIDVA) programmes in maternity services in England. The results showed that 69% of the surveyed trusts reported having a hIDVA programme, with 55% of them operating within maternity services. Key facilitators for implementation included staff training, communication, co-creation, and support from management. Barriers included lack of private workspace, funding issues, and recruitment challenges for hIDVA staff.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Margaret Heslin, Amelia Jewell, Sara Croxford, Cuong Chau, Shubulade Smith, Rudiger Pittrof, Elana Covshoff, Ann Sullivan, Valerie Delpech, Alison Brown, Helena P. King, Mina Kakaiya, Lucy Campbell, Elizabeth Hughes, Robert Stewart
Summary: A retrospective cohort study in the UK found that the prevalence of HIV in people who have used secondary mental health services was 2.47%, which is approximately 2.5 times higher than the general population in the same geographical area. Further research is needed to investigate risk factors and disparities in HIV outcomes between those with and without mental health service contact.
Article
Psychiatry
Clara Strauss, Anna-Marie Bibby-Jones, Fergal Jones, Sarah Byford, Margaret Heslin, Glenys Parry, Michael Barkham, Laura Lea, Rebecca Crane, Richard de Visser, Amy Arbon, Claire Rosten, Kate Cavanagh
Summary: Practitioner-supported mindfulness-based cognitive therapy self-help (MBCT-SH) is superior to practitioner-supported cognitive behavioral therapy self-help (CBT-SH) in reducing depressive symptoms in mild to moderate depression and is cost-effective. The findings suggest that MBCT-SH should be routinely offered to adults in primary care services for mild to moderate depression.
Article
Psychology, Clinical
Eshim S. Jami, Megan Pritchard, Hitesh Shetty, Robert Stewart, Allan H. Young, Margaret Heslin
Summary: This study investigates the use of antidepressant and antipsychotic treatment for Psychotic Major Depression (PMD) in clinical practice and examines how treatment profiles correlate with demographic and clinical symptoms. The results showed that combined antidepressant and antipsychotic pharmacotherapy is the most common treatment for PMD in clinical practice, in line with evidence from treatment research.
JOURNAL OF MENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Polly-Anna Ashford, Clare Knight, Margaret Heslin, Allan B. Clark, Mona Kanaan, Ushma Patel, Freya Stuart, Thomas Kabir, Nick Grey, Hannah Murray, J. Hodgekins, Nesta Reeve, Nicola Marshall, Michelle Painter, James Clarke, Debra Russo, Jan Stochl, Maria Leathersich, Martin Pond, David Fowler, Paul French, Ann Marie Swart, Mary Dixon-Woods, Sarah Byford, Peter B. Jones, Jesus Perez
Summary: This study aims to evaluate the clinical and cost-effectiveness of enhanced training for cognitive behavioural therapists in addressing the clinical gap of individuals with common mental disorder including psychotic experiences in the primary care improving access to psychological therapies (IAPT) programme in England.
Article
Psychology, Clinical
Margaret Heslin, Judith Gellatly, Rebecca Pedley, Jasmin Knopp-Hoffer, Gillian Hardy, Catherine Arundel, Penny Bee, Dean McMillan, Emily Peckham, Lina Gega, Michael Barkham, Peter Bower, Simon Gilbody, Karina Lovell, Sarah Byford
Summary: This study examines the type and quantity of out of pocket expenses reported by a large sample of adults with OCD. The results indicate that 45% of patients incur out of pocket expenses due to their OCD, with an average weekly cost of approximately £19.19.
JOURNAL OF MENTAL HEALTH
(2022)