Article
Medicine, General & Internal
Erland Hermansen, Ivar Magne Austevoll, Christian Hellum, Kjersti Storheim, Tor Age Myklebust, Jorn Aaen, Hasan Banitalebi, Masoud Anvar, Frode Rekeland, Jens Ivar Brox, Eric Franssen, Clemens Weber, Tore K. Solberg, Havard Furunes, Oliver Grundnes, Helena Brisby, Kari Indrekvam
Summary: This study compared the effectiveness of three minimally invasive posterior decompression techniques for lumbar spinal stenosis and found no differences in clinical outcomes or complication rates among the three techniques.
Article
Orthopedics
Ofir Uri, Liad Alfandari, Yoram Folman, Amit Keren, William Smith, Inbar Paz, Eyal Behrbalk
Summary: This study compared the incidence of acute disc herniation following mini-open and minimally invasive decompression of lumbar spinal stenosis. The results showed that the incidence of postoperative disc herniation was significantly lower in the minimally invasive group compared to the mini-open group.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Clinical Neurology
Kyle W. Morse, Michael Steinhaus, Patawut Bovonratwet, Gregory Kazarian, Catherine Himo Gang, Avani S. Vaishnav, Virginie Lafage, Renaud Lafage, Sravisht Iyer, Sheeraz Qureshi
Summary: This study aimed to describe the current treatment practices for degenerative spondylolisthesis (DS) and identify the radiographic and clinical factors that influence the decision to perform fusion in patients with one-level DS. The results showed that there is little consensus on the treatment of DS, with a majority of surgeons opting for fusion. The most common radiographic factors impacting the decision to fuse were instability, spondylolisthesis grade, and laterolisthesis, while the most common clinical factors were mechanical low back pain, activity level, and neurogenic claudication.
Article
Clinical Neurology
Jack Horan, Mohammed Ben Husien, Ciaran Bolger
Summary: The study compared the outcomes of minimally invasive bilateral laminotomy via unilateral approach and open laminectomy in the treatment of lumbar spinal stenosis. The results showed that minimally invasive procedures were superior in improving pain and disability outcomes compared to open laminectomy, with advantages in shorter hospital stays and lower complication rates.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Jun Zhang, Tang-Fen Liu, Hua Shan, Zhong-Yuan Wan, Zhe Wang, Omar Viswanath, Antonella Paladini, Giustino Varrassi, Hai-Qiang Wang
Summary: Lumbar spinal stenosis (LSS) is a common disease in the elderly population, often requiring surgery. Minimally invasive spine surgery (MISS), including techniques like endoscopic spine surgery (ESS), is gaining popularity as a potential replacement for traditional open surgery in the treatment of LSS associated with degenerative spondylolisthesis (DS).
Article
Clinical Neurology
Julia Bergquist, Madeline E. Greil, Siri Sahib S. Khalsa, Yuhao Sun, Osama N. Kashlan, Christoph P. Hofstetter
Summary: This study investigated whether the utilization of a working channel endoscope can mitigate challenges associated with obesity in spine surgery. The results showed that the use of an endoscope can partially mitigate obesity-related complications in lumbar decompression surgery, but obesity is significantly related to increased postoperative analgesic use.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Talat Cem Ovalioglu, Aysegul Ozdemir Ovalioglu, Gokhan Canaz, Muslum Gunes, Mert Babur, Erhan Emel
Summary: This study evaluated the clinical and radiological outcomes of spinous process splitting decompression (SPSD) compared with conventional laminectomy for the treatment of degenerative lumbar spinal stenosis. The results showed comparable functional recovery rates and pain relief effects between the two surgical techniques.
WORLD NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Hyeun-Sung Kim, Sagar B. Sharma, Harshavardhan D. Raorane, Kyeong-Rae Kim, Il-Tae Jang
Summary: This retrospective study examined the outcomes of full-endoscopic decompression in patients with lumbar central canal stenosis. The results showed significant improvement in back and leg pain, functional recovery, and radiographic changes that were maintained at the 1-year follow-up. The study suggests that full endoscopic outside-in decompression is a safe and effective option for this condition with minimal invasive advantages.
Article
Clinical Neurology
Jung-Hoon Kim, Young-Jin Kim, Kyeong-Sik Ryu, Jin-Sung Kim
Summary: This study aimed to compare the short-term clinical and radiological outcomes of full-endoscopic lumbar laminotomy (FEL) and subtotal lumbar laminectomy (STL) for lumbar spinal stenosis (LSS). The results showed that both groups had significant improvements in pain scores and functional disability after the surgery. The FEL group had a significantly shorter hospital stay, and improvements in lumbar lordosis and segmental angle were observed in both groups. Additionally, exacerbation or development of spondylolisthesis was higher in the STL group, while improvement was seen in the FEL group. Overall, FEL was comparable to STL in clinical outcomes but superior in terms of shorter hospital stay and radiologic instability. Therefore, FEL can be considered as a surgical method comparable to STL for LSS.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Jacob L. Goldberg, Christoph Wipplinger, Sertac Kirnaz, Jimmy Xia, Fabian Sommer, Alicia Meng, Justin Schwarz, Alexandra Giantini-Larsen, Ross M. Meaden, Rafael Sugino, Pravesh Gadjradj, Branden Medary, Joseph A. Carnevale, Rodrigo Navarro, A. John Tsiouris, Ibrahim Hussain, Roger Hartl
Summary: This study investigates the relationship between redundant nerve roots (RNRs) and clinical outcomes after minimally invasive tubular decompression for symptomatic lumbar spinal stenosis (LSS). The study found that preoperative RNRs are associated with increased age, symptom duration, and lumbar stenosis severity. However, patients improved after surgery regardless of RNR presence. Further research is needed to assess the long-term significance of RNRs.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Yuto Kobayashi, Koji Tamai, Hiromitsu Toyoda, Hidetomi Terai, Masatoshi Hoshino, Akinobu Suzuki, Shinji Takahashi, Yusuke Hori, Akito Yabu, Hiroaki Nakamura
Summary: Results from a study involving 198 patients with LSS indicate that there was no significant difference in clinical outcomes 5 years after minimally invasive posterior decompression between patients with degenerative spondylolisthesis (DS) and those without DS. Additionally, after carefully excluding patients with segmental instability, DS did not impact the clinical outcomes of minimally invasive decompression surgery.
Editorial Material
Clinical Neurology
Ethan S. Srinivasan, Clifford L. Crutcher, Timothy Y. Wang, Peter M. Grossi, Khoi D. Than
Summary: Minimally invasive lumbar laminectomies using tubular retractors reduce tissue disturbance and blood loss, resulting in smaller incisions and significant improvement in postoperative symptoms for patients.
OPERATIVE NEUROSURGERY
(2021)
Article
Clinical Neurology
Bing Tan, Qi-Yuan Yang, Bin Fan, Chuang Xiong
Summary: This study compared the clinical outcomes of two surgical methods (unilateral biportal endoscopy and conventional open lumbar discectomy) in patients with severe degenerative lumbar spinal stenosis. The results showed that unilateral biportal endoscopy achieved comparable efficacy to conventional surgery, but had a shorter hospital stay, less blood loss, and reduced damage to paravertebral muscles.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Hongjie Yuan, Xiaobin Yi
Summary: This narrative review aims to clarify the efficacy, safety profile, certain procedure details, advantages, and limitations of MILD for LSS. According to the literature, MILD is an effective and safe procedure that can significantly reduce pain intensity and improve functional status in LSS patients.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Xiang Yu, Hongwei Yue, Huawei Wei, Quanjin Li, Zhiming Li
Summary: This study aimed to compare the efficacy of unilateral biportal endoscopic (UBE) surgery and traditional open surgery in the treatment of lumbar disc herniation (LDH), as well as discuss the complications and learning curve of UBE surgery. The results showed that both UBE and traditional open surgery were effective in treating LDH. The UBE surgery group had better early pain relief and a lower incidence of long-term chronic low back pain compared to the traditional open surgery group, but the UBE group had a higher incidence of early complications compared to the traditional open surgery group.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Review
Clinical Neurology
Radek Fric, Bard Nedregaard, Ketil Riddevold Heimdal, Clemens Weber, Bernt Johan Due-Tonnessen
Summary: We report a rare case of massive subarachnoid and intraventricular hemorrhage in a 3-week-old neonate due to a ruptured aneurysm of the anterior communicating artery. The neonate died a few days after the hemorrhage, as a result of a disastrous supratentorial cerebral infarction. There are limited cases of anterior communicating artery aneurysm in newborns reported, making this condition extremely rare. No data comparing the efficacy and safety of microsurgical versus endovascular treatment in neonates and small infants are available, but endovascular treatment may reduce the associated risks.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Neurosciences
Sabina Ake, Lena Hartelius, Asgeir S. Jakola, Malin Antonsson
Summary: The purpose of this study was to investigate the experiences of individuals who had received different treatments for glioma in their language, speech, and communication in daily life. The interviews revealed that participants experienced changes in communication skills, including word finding, motor speech, and comprehension. They also expressed frustration and the need for greater effort in their communication. Participants adapted their way of living and used multiple strategies to manage these changes. Uncertainty was identified as a key theme, reflecting the impact of living with a slow-growing brain tumor on life decisions and perceptions of symptoms. The implications of these findings for research and healthcare are discussed.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Neurosciences
Sandra Ferreyra Vega, Thomas Olsson Bontell, Teresia Kling, Asgeir Store Jakola, Helena Caren
Summary: This study investigated the DNA methylation changes associated with tumor progression in primary and recurrent IDH-mutant gliomas. It was found that a subset of IDH-mutant astrocytomas exhibited a switch in methylation subtypes, with the primary tumors classified as low-grade astrocytomas progressing to high-grade astrocytomas in the recurrent tumors. The number of differentially methylated CpG sites increased over time, and astrocytomas accumulated more differentially methylated CpG sites than oligodendrogliomas during tumor progression.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Oncology
Olivia Naslund, Per Sveino Strand, Thomas Skoglund, Ole Solheim, Asgeir S. Jakola
Summary: Meningioma, with a prevalence of around 1%, is increasingly being detected incidentally due to the use of diagnostic imaging modalities. There is no clear consensus on its management, but active monitoring is suggested if no aggravating factors emerge. However, there are no collective guidelines on follow-up intervals.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Sofie Eline Tollefsen, Ole Solheim, Patricia Mjones, Sverre Helge Torp
Summary: Meningioma is a common brain tumor without approved specific drugs. This study aims to compile the current insights of somatostatin analogs for treating patients with meningioma. A systematic search was conducted, and 17 eligible studies were evaluated. Although the efficacy of somatostatin analogs remains unclear, some studies suggest that they may be a last-option treatment for severely ill-patients. However, a controlled study or randomized clinical trial is needed to establish their efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Margret Jensdottir, Ulrika Sandvik, Asgeir S. Jakola, Michael Fagerlund, Annika Kits, Klara Guomundsdottir, Sara Tabari, Tomas Majing, Alexander Fletcher-Sandersjoeoe, Clark C. Chen, Jiri Bartek
Summary: Although there is a learning curve in the first 30 cases, our findings suggest that experienced neurosurgical centers can safely adopt this technique. The lack of standardized reporting in the literature hampers comparison of the learning curve and adverse events, thus we recommend embracing a more standardized system for reporting outcomes.
NEUROSURGERY CLINICS OF NORTH AMERICA
(2023)
Article
Clinical Neurology
Christian Hellum, Frode Rekeland, Milada Cvancarova Smastuen, Tore Solberg, Erland Hermansen, Kjersti Storheim, Jens Ivar Brox, Havard Furunes, Eric Franssen, Clemens Weber, Helena Brisby, Oliver Grundnes, Knut Robert Hector Algaard, Tordis Boker, Hasan Banitalebi, Kari Indrekvam, Ivar Magne Austevoll
Summary: This study examined treatment effect modifiers and prognostic variables in patients with spinal stenosis and degenerative spondylolisthesis. The results showed that previously defined instability criteria and other baseline variables were not associated with better clinical outcomes when fusion surgery was performed. Less comorbidity and more leg pain were identified as factors associated with improved outcomes in both treatment groups.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Karlberg, Lars Kjelsberg Pedersen, Benedikte Emilie Vindstad, Anne Jarstein Skjulsvik, Hakon Johansen, Ole Solheim, Karoline Skogen, Kjell Arne Kvistad, Trond Velde Bogsrud, Kristin Smistad Myrmel, Guro F. Giskeodegard, Tor Ingebrigtsen, Erik Magnus Berntsen, Live Eikenes
Summary: This study aims to evaluate the correlation between anti-3-[F-18]FACBC PET combined with conventional MRI and histomolecular diagnosis in glioma diagnostics. The study found that anti-3-[F-18]FACBC PET has high uptake in the majority of gliomas and improves the accuracy of preoperatively predicted glioma diagnoses.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Louise Carstam, Francesco Latini, Ole Solheim, Jiri Bartek Jr, Lars K. Pedersen, Maria Zetterling, Stanislav Beniaminov, Kristin Sjavik, Mats Ryttlefors, Margret Jensdottir, Bertil Rydenhag, Anja Smits, Asgeir S. Jakola
Summary: The study aimed to describe the long-term course of oligodendroglioma disease in a population-based setting and determine factors affecting survival. Patients with WHO-grade 2 oligodendrogliomas and known 1p19q-codeletion were analyzed, with a median follow-up of 12.0 years and a median survival of 17.8 years. Factors associated with shorter survival include age, tumor diameter, and poor preoperative functional status.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Letter
Medicine, General & Internal
Sozaburo Hara, Hege Andresen, Ole Solheim, Sven M. Carlsen, Asgeir S. Jakola, Oyvind O. Salvesen, Sasha Gulati
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Olivia Naslunda, Anna Lipatnikova, Anna Denes, Cecilia Lindskog, Thomas Olsson Bontell, Anja Smits, Asgeir S. Jakola, Alba Corell
Summary: This study aimed to evaluate the clinical usefulness of the immunohistochemistry markers S100B, SCGN, ACADL, and MCM2. Analysis of 244 meningioma patients' samples revealed difficulties in applying the classification system using these markers, indicating a lack of clinical applicability for the current classification method.
Correction
Clinical Neurology
A. Bartley, J. Bartek Jr, A. S. Jakola
Article
Oncology
Olivia Naeslund, Per Sveino Strand, Ole Solheim, Mohammad Al Masri, Okizeva Rapi, Erik Thurin, Asgeir S. Jakola
Summary: The purpose of this study was to investigate the use of brain scanning and the findings of incidental meningioma in two different time periods. The results showed an increase in patients diagnosed with incidental asymptomatic meningioma in recent years, possibly due to more contrast-enhanced scans and a higher number of scans among the elderly.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Stine Schei, Lisa Millgard Sagberg, Lars Eirik Bo, Ingerid Reinertsen, Ole Solheim
Summary: The location of glioblastoma may have an impact on the cognitive function of patients. Specifically, before surgery, tumors in the left hemisphere are significantly associated with reduced patient-reported cognitive function.
NEUROSURGICAL REVIEW
(2023)
