Article
Endocrinology & Metabolism
Benjamin Batteux, Youssef Bennis, Sandra Bodeau, Kamel Masmoudi, Anne-Sophie Hurtel-Lemaire, Said Kamel, Valerie Gras-Champel, Sophie Liabeuf
Summary: New disproportionality signals for drugs associated with osteoporosis were detected through an analysis of the World Health Organization's VigiBase (R) pharmacovigilance database. Drugs used in neurology, hematology, pulmonology, ophthalmology, and rheumatology with pharmacologically plausible mechanisms leading to bone fragility were highlighted. The results provide insights for further exploration of these mechanisms.
Article
Pharmacology & Pharmacy
Marion Allouchery, Cecile Tomowiak, Stephanie Guidez, Vincent Delwail, Paul Delaunay, Claire Lafay-Chebassier, Francesco Salvo, Marie-Christine Perault-Pochat
Summary: This study provided real-life data on patterns of use and safety of ibrutinib, showing a high cumulative incidence of ibrutinib-associated serious adverse drug reactions (SADRs) within the first year of treatment. Patients aged >= 80 years or treated for chronic lymphocytic leukaemia (CLL) were significantly associated with a higher risk of SADR occurrence and deserve special attention.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Hematology
Muireann Walton, Robert Tomkies, Thomas Teunissen, Thomas Lumley, Timothy Hanlon
Summary: A study in New Zealand found no significant association between the BNT162b2 COVID-19 vaccine and thrombosis, providing reassurance for its safety in the general population.
THROMBOSIS RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Yan Yang, Fei-Lin Ge, Jin-Fa Tang, Shuang-Lin Qin, Rui Zeng, Meng-Lin Yao, Xiao-He Xiao, Zhao-Fang Bai, Cheng-Lin Tang
Summary: Herb-induced liver injury (HILI) is a growing concern due to its impact on public health and medical resources. This review focuses on the epidemic situation of HILI in mainland China and explores potential risk factors by examining patients, drugs, and unreasonable prescriptions.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Medicine, General & Internal
David A. Henry, Mark A. Jones, Paulina Stehlik, Paul P. Glasziou
Summary: Community-based studies in five countries consistently show strong benefits from early rollouts of COVID-19 vaccines.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Article
Health Care Sciences & Services
Toshihiro Yamaguchi, Masao Iwagami, Chieko Ishiguro, Daisuke Fujii, Norihisa Yamamoto, Manabu Narisawa, Takashi Tsuboi, Hikari Umeda, Natsumi Kinoshita, Toyotaka Iguchi, Tatsuya Noda, Shinya Tsuruta, Akira Oka, Tomohiro Morio, Kiyohito Nakai, Shuichiro Hayashi
Summary: The assessment of the efficacy and safety of COVID-19 vaccines is crucial, and in Japan, a joint council regularly evaluates adverse events following vaccination and takes safety-related regulatory actions. Sharing vaccine safety information and evaluation systems internationally is important for better monitoring of COVID-19 vaccine safety.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Review
Pharmacology & Pharmacy
Mia Aakjaer, Marie Louise De Bruin, Morten Andersen
Summary: This study aims to explore methods for sequential analysis of electronic healthcare data to address the limitations of spontaneous reporting systems. Through literature review and experimentation, it has been demonstrated that the use of sequential analysis can successfully conduct epidemiological surveillance of various exposures and outcomes. However, there is a relative lack of research on analyzing data at multiple time points in realistic settings.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Volkan Aydin, Ayfer Bahar, Caner Vizdiklar, Ahmet Akici
Summary: This study compares the chiral status of available drugs with drugs withdrawn due to adverse drug reactions and finds that pure enantiomers have a lower likelihood of withdrawal, especially in certain time periods and specific ADRs.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Haona Li, Jianxiong Deng, Peiming Yu, Xuequn Ren
Summary: This study analyzed individual case safety reports (ICSRs) with an outcome of death to characterize drug-related deaths in China. The results showed that young children, elderly patients, and female patients aged 20-34 years have a higher risk of drug-related deaths. Further research on the safe use of drugs for these populations is recommended.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Emergency Medicine
Indira Valade Carvalho, Vanessa Marcilio de Sousa, Marilia Berlofa Visacri, Julia Coelho Franca Quintanilha, Cinthia Madeira de Souza, Rosiane Fatima Lopes Ambrosio, Marcelo Conrado dos Reis, Rachel Alvarenga de Queiroz, Priscila Gava Mazzola, Tais Freire Galvao, Patricia Moriel
Summary: This study found a high frequency of ADE-related admissions in a pediatric emergency unit, with neurological, dermatological, and respiratory disorders associated with an increased risk of ADE-related admissions. Clinical pharmacists play a crucial role in identifying ADEs and educating caregivers and healthcare providers about pediatric medication.
PEDIATRIC EMERGENCY CARE
(2021)
Editorial Material
Immunology
Richard K. Zimmerman
Summary: Many people with religious convictions are hesitant about COVID-19 vaccines due to concerns about fetal cell lines, but religious texts and leaders support prevention and vaccination. Clinicians can address patient concerns through ethical analysis, altruism, religious support, and providing vaccines developed without fetal cell lines.
Article
Public, Environmental & Occupational Health
Siyuan Gao, Zhichao He, Jianhong Zhu, Dan Liang, Wenxia Zhao, Shan Yang, Wei Jiang, Kaifeng Qiu, Xiaoxia Yu, Junyan Wu
Summary: This study reveals the relationship between ileus and immune checkpoint inhibitors (ICIs) treatment using real-world cases from the FDA Adverse Event Reporting System (FAERS).
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Immunology
Greta Santi Laurini, Nicola Montanaro, Massimiliano Broccoli, Giulia Bonaldo, Domenico Motola
Summary: Since the first COVID-19 messenger RNA vaccines became available globally, post-marketing surveillance activities have been implemented to monitor any adverse events. Safety data from the Vaccine Adverse Event Reporting System (VAERS) were analyzed for the BNT162b2 and mRNA-1273 vaccines. The survey showed evidence of the favorable safety profile of mRNA vaccines, despite some rare adverse events.
Article
Oncology
N. E. Omar, A. I. Fahmy Soliman, M. Eshra, T. Saeed, A. Hamad, A. Abou-Ali
Summary: Analysis of FAERS data revealed significant safety signals for several ALK inhibitors, including risks related to eye disorders, respiratory disorders, and metabolism disorders. Further regulatory investigation is needed to verify the significance of these signals and potentially update product labels.
Article
Chemistry, Multidisciplinary
Jack L. Janetzki, Nicole L. Pratt, Michael B. Ward, Matthew J. Sykes
Summary: In-silico molecular modelling approaches identified that certain registered drugs may inhibit Glutathione Peroxidase 1 and contribute to the development of chronic obstructive pulmonary disease. Further pharmacovigilance and biological analyses are required to ensure appropriate use of these medications.
PHARMACEUTICAL RESEARCH
(2023)
Article
Rehabilitation
Lauren Cadel, Sander L. Hitzig, Tanya L. Packer, Tejal Patel, Aisha K. Lofters, Alison Thompson, Sara J. T. Guilcher
Summary: This study aimed to explore the attitudes, beliefs, and experiences of community-dwelling adults with spinal cord injury/dysfunction (SCI/D) in Ontario, Canada, regarding the management of prescribed and unprescribed medications. The findings revealed that medication management is a complex process that does not align with current medication management frameworks. Therefore, it is important to consider the self-management experiences of individuals with SCI/D in future research, practice, and policy.
DISABILITY AND REHABILITATION
(2022)
Article
Ethics
Maxwell J. Smith
Summary: While age is a significant factor in COVID-19 vaccine distribution, it should not be the sole criterion for prioritization, and younger populations should also be considered. This article examines arguments against exclusively using age-based prioritization and highlights ethical reasons for a more nuanced approach.
JOURNAL OF MEDICAL ETHICS
(2022)
Article
Public, Environmental & Occupational Health
Kadesha A. James, Amanda C. Everall, Lauren Cadel, Lisa M. McCarthy, Aisha Lofters, Alison Thompson, Sara J. T. Guilcher
Summary: This study explores the priorities and contributions of individuals with chronic medication experience to the understanding of medication self-management. The results enhance existing medication management frameworks by providing a more comprehensive perspective. Further research is needed to understand medication self-management from the perspectives of individuals managing their medications.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2022)
Editorial Material
Public, Environmental & Occupational Health
Eugenia Canas, Robert Gough, Maxwell J. Smith, Erynn M. Monette, David D. McHugh, Marlene Janzen Le Ber, Tanya E. Benjamin-Thomas, Yvonne Kasine, Aimee J. Utuza, Elysee Nouvet
Summary: Translation emphasizes the role of language in global health and the importance of careful consideration when using words; it also highlights the need to clarify and discuss the phrase "critical and ethical global engagement."
GLOBAL PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Suerie Moon, Jana Armstrong, Brian Hutler, Ross Upshur, Rachel Katz, Caesar Atuire, Anant Bhan, Ezekiel Emanuel, Ruth Faden, Prakash Ghimire, Dirceu Greco, Calvin W. L. Ho, Sonali Kochhar, G. Owen Schaefer, Ehsan Shamsi-Gooshki, Jerome Amir Singh, Maxwell J. Smith, Jonathan Wolff
Summary: The Access to COVID-19 Tools Accelerator (ACT-A) is a multi-stakeholder initiative aiming to achieve equitable access to COVID-19 health technologies. However, its governance faces challenges in terms of unclear organizational roles, lack of a clearly defined decision making body, and the indiscernible role of governments.
Article
Anesthesiology
James Downar, Maxwell J. Smith, Dianne Godkin, Andrea Frolic, Sally Bean, Cecile Bensimon, Carrie Bernard, Mary Huska, Mike Kekewich, Nancy Ondrusek, Ross Upshur, Randi Zlotnik-Shaul, Jennifer Gibson
Summary: During the COVID-19 pandemic, there was a surge in demand for critical care, which put a strain on healthcare systems. A framework was developed to guide the allocation of critical care resources, with three levels of triage and prioritization based on short-term mortality risk. It aims to promote consistency and fairness across multiple hospitals.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Review
Immunology
Jerome Amir Singh, Sonali Kochhar, Jonathan Wolff, Caesar Atuire, Anant Bhan, Ezekiel Emanuel, Ruth Faden, Prakash Ghimire, Dirceu Greco, Calvin Ho, Suerie Moon, Ehsan Shamsi-Gooshki, Aissatou Toure, Beatriz Thome, Maxwell J. Smith, Ross E. G. Upshur
Summary: The increase in vaccination coverage for COVID-19 raises questions about the prevention standards that should be applied in different trial settings. The WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global vaccine coverage, considering alternative trial designs as well.
Editorial Material
Health Care Sciences & Services
Teck Chuan Voo, Maxwell J. Smith, Ignacio Mastroleo, Angus Dawson
Summary: The differential public health and social measures based on individual vaccination status have raised ethical considerations. Decisions on lifting measures for vaccinated individuals should be guided by scientific and ethical considerations to balance public health and freedom of movement, and mitigate unfair disadvantages.
EASTERN MEDITERRANEAN HEALTH JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Rachel Alberta Katz, Fabio Salamanca-Buentello, Diego S. Silva, Ross E. G. Upshur, Maxwell J. Smith
Summary: The distribution and development process of COVID-19 vaccines is marked by injustice, particularly in low-income and middle-income countries. Past experiences suggest that vaccine development should focus on establishing multiple levels of trust, strong and fair governance, and broad research collaborations.
Editorial Material
Public, Environmental & Occupational Health
Maxwell J. Smith
Editorial Material
Medicine, General & Internal
Ezekiel J. Emanuel, Ross E. G. Upshur, Maxwell J. Smith
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Ethics
Diego S. Silva, Maxwell J. Smith
Summary: This article discusses the justification for implementing measures that impose risk on some individuals but not others in the context of public health. It argues for a focus on relational autonomy and relational justice, emphasizing the role of power and context in determining the permissibility of certain risks.
ASIAN BIOETHICS REVIEW
(2023)
Article
Rehabilitation
Diego Augusto Santos Silva, Carolina Fernandes da Silva
Summary: Brazil lacks specific policies for promoting adapted physical activity for children and adolescents with disabilities.
ADAPTED PHYSICAL ACTIVITY QUARTERLY
(2023)
Meeting Abstract
Geriatrics & Gerontology
Chaoran Wu, Aleksandra Zecevic, Maxwell Smith, Shannon Sibbald
INNOVATION IN AGING
(2021)
Review
Ethics
Nicholas Murphy, Charles Weijer, Maxwell Smith, Jennifer Chandler, Erika Chamberlain, Teneille Gofton, Marat Slessarev
Summary: cDCDD is an important strategy for increasing the pool of eligible organ donors by determining organ donation after circulatory death.
JOURNAL OF LAW MEDICINE & ETHICS
(2021)