Review
Oncology
Bin Zhao, Meiling Gao, Hong Zhao, Jiaxin Zhao, Xian Shen
Summary: Avelumab monotherapy shows more tumor responses and less adverse events compared to conventional treatment, with better efficacy in PDL1 positive patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
F. Gomes, P. Lorigan, S. Woolley, P. Foden, K. Burns, J. Yorke, F. Blackhall
Summary: Older cancer patients are not at higher risk for high-grade toxicity when using CPI. The G8 screening can identify a high-risk subgroup of patients and its implementation should be considered in the context of CPI.
Article
Oncology
Xiaoning Guo, Xiaohui Wang, Sui Shen, Bryan Oronsky, Tony R. Reid, Meaghan Stirn, Scott Caroen, Franck Brinkhaus, Nacer A. Abrouk, Liandai Yang, Lianzong Wu, Zhongwen Yu
Summary: This post-hoc analysis shows that there are no apparent differences in terms of safety and efficacy when RRx-001 is combined with chemotherapy in cancer patients with Asian ancestry.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Immunology
Zsofia Foldvari, Cathrine Knetter, Weiwen Yang, Thea Johanne Gjerdingen, Ravi Chand Bollineni, Trung The Tran, Fridtjof Lund-Johansen, Arne Kolstad, Kimberley Drousch, Robert Klopfleisch, Matthias Leisegang, Johanna Olweus
Summary: This study developed a new method to assess off-target reactivity of T cell receptor-engineered T cells in cancer immunotherapy. The study evaluated TCR-T off-target reactivity through mapping target amino acids, computational search for cross-reactive peptides, and screening against candidate peptides in the human proteome. The research demonstrated the importance of studying recognition of full-length candidate off-targets and the widely applicable strategy can facilitate evaluation of therapeutic TCRs and inform clinical decision-making.
Article
Multidisciplinary Sciences
Tito R. Mendoza, David S. Hong, Christine B. Peterson, Bettzy Stephen, Ecaterina Dumbrava, Shubbam Pant, Apostolia Maria Tsimberidou, Timothy Anthony Yap, Ajay Sheshadri, Mehmet Altan, Goldy George, Lilibeth Castillo, Enedelia Rodriguez, Jing Gong, Vivek Subbiah, Filip Janku, Siqing Fu, Sarina A. Piha-Paul, Jordi Rodon Ahnert, Daniel D. Karp, Charles Cleeland, Funda Meric-Bernstam, Aung Naing
Summary: This study aimed to investigate the symptom burden and trajectory of patients with rare solid tumors treated with immunotherapy. The results showed that fatigue, pain, disturbed sleep, lack of appetite, and drowsiness were the most severe symptoms reported by patients, while symptoms such as abdominal pain, rash, and diarrhea were less severe. Some rare malignancy patients experienced high symptom burden even at the beginning of the treatment, and the symptom burden remained stable over the 9-week treatment period.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Michael C. Tjong, Malavan Ragulojan, Ian Poon, Alexander V. Louie, Susanna Y. Cheng, Mark Doherty, Liying Zhang, Yee Ung, Patrick Cheung, Parneet K. Cheema
Summary: The study investigated the association between radiation therapy timing and toxicities within 14 and 90 days of immune checkpoint inhibitor use for advanced non-small-cell lung cancer patients. The results suggested that there was no significant association between radiation therapy timing relative to the use of immune checkpoint inhibitors and toxicities.
Review
Nanoscience & Nanotechnology
Milad Mohkam, Mohammad Sadraeian, Antonio Lauto, Ahmad Gholami, Seyed Hesamodin Nabavizadeh, Hossein Esmaeilzadeh, Soheila Alyasin
Summary: This article introduces the potential uses of quantum dots in allergy research, including their applications in allergy diagnosis and treatment. The article provides an overview of the properties and applications of quantum dots, and discusses their toxicity and biocompatibility.
MICROSYSTEMS & NANOENGINEERING
(2023)
Review
Oncology
Pierre-Yves Borius, Jean Regis, Alexandre Carpentier, Michel Kalamarides, Charles Ambroise Valery, Igor Latorzeff
Summary: The review found that the combination of SRS with systemic therapy for brain metastases is safe and has low toxicity. Studies are mainly focused on melanoma, lung, breast, and renal carcinoma, with no significant increase in radiation necrosis or bleeding observed.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Ganlu Ouyang, Yanyang Liu, Jiewei Liu, Lin Huang, Feng Luo, Lu Li
Summary: This study aimed to demonstrate the efficacy and safety of reduced-dose chemotherapy plus immunotherapy in lung squamous cell carcinoma (LUSC) patients in the real world. The results showed that the reduced-dose chemotherapy group had similar efficacy and tolerability compared to the standard-dose group, with fewer side effects.
Editorial Material
Biochemistry & Molecular Biology
Fausto Meriggi, Alberto Zaniboni, Anna Zaltieri
Summary: The development and use of immunotherapy in the last decade have greatly improved results in the onco-haematological field. However, clinicians need to manage new adverse events and deal with increased costs. Emerging scientific evidence suggests that low-dose immunotherapy can be effective and cost-saving, benefiting a larger audience of cancer patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Muhammad O. Awiwi, Ala Abudayyeh, Noha Abdel-Wahab, Adi Diab, Migena Gjoni, Guofan Xu, Raghu Vikram, Khaled Elsayes
Summary: This study describes the imaging features of immunotherapy-related nephritis on CT and PET, and investigates the association of radiologic features with clinical outcomes. The results show that nephritis is associated with increased kidney volume, perinephric fat stranding, and hypoenhancing cortical foci. PET-CT shows increased radiotracer uptake in the renal cortex and decreased radiotracer activity in the renal pelvis.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Amir Abbas Momtazi-Borojeni, Maciej Banach, Sayed Abbas Tabatabaei, Amirhossein Sahebkar
Summary: The antiPCSK9 vaccine is safe and does not have adverse effects on the function of different organs and blood levels of cellular and biochemical biomarkers in healthy mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Soon-Tae Lee, Han Sang Lee, Woo-Jin Lee, Han-A Cha, Seon Hui Kim, Seo-Yi Shin, Kon Chu, Sang Kun Lee
Summary: This single-arm, open-label study demonstrated the significant functional recovery effect of IVIG treatment in patients with autoimmune encephalitis, improving their quality of life. The improvement in neurological function was evident as early as day 8 after IVIG treatment, showing promising potential as an effective therapeutic option for autoimmune encephalitis.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qi Jiang, Mengchun Chen, Xuewei Yang, Deli Zhuge, Qingqing Yin, Dongyan Tian, Li Li, Xufei Zhang, Wenbin Xu, Shuangshuang Liu, Fan Li, Cuiye Weng, Yijing Lin, Haonan Wang, Dapang Rao, Yiming Chen, Qiangjun Cai, Linzhi Yan, Ledan Wang, Fang Wang, Xiaosheng Lu, Bin Wen, Yingzheng Zhao, Feng Zhang, Weiliang Xia, Haiyan Zhu, Yijie Chen
Summary: Researchers have developed a biomimetic nanoparticle that can enhance the effectiveness of chemotherapy drugs for cancer treatment while reducing their toxicity. This nanoparticle can selectively target healthy tissue and prevent the drug from damaging healthy cells, enabling higher drug doses to be delivered to tumor tissue without toxicity. The nanoparticle also activates the immune system to attack tumors. In mouse tumor models, pretreatment with this nanoparticle followed by high-dose chemotherapy significantly prolonged survival.
Article
Plant Sciences
Peng Wang, Hongrui Cao, Shuxuan Quan, Yong Wang, Mu Li, Ping Wei, Meng Zhang, Hui Wang, Hongyu Ma, Xiaofeng Li, Zhong-Bao Yang
Summary: Aluminium toxicity is a major constraint for crop production in acidic soil, and improper nitrogen fertilizer usage can worsen soil acidification. This study investigates the regulatory mechanism of nitrate (NO3-) in the resistance of maize and Arabidopsis to aluminium. Nitrate conservatively improves aluminium resistance by promoting citrate synthesis and exudation, which helps exclude aluminium ions from the plant roots. ZmSLAH2 in maize and AtSLAH1 in Arabidopsis are essential for citrate exudation and NO3--promoted aluminium resistance, with ZmMYB81 activating ZmSLAH2 expression. NO3- transport, mediated by ZmNRT1.1A and AtNRT1.1, is also necessary for NO3--promoted aluminium resistance, while ammonium (NH4+) inhibition of NO3- transport hinders this resistance. This study provides important insights into the role of NO3--mediated signaling in plant aluminium resistance and offers guidance for nitrogen fertilizer application in acidic soils.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Allergy
Alexander Heldner, Francesca Alessandrini, Dennis Russkamp, Sonja Heine, Benjamin Schnautz, Adam Chaker, Juliet Mwange, Thalia L. Carreno Velazquez, Matthew D. Heath, Murray A. Skinner, Matthias F. Kramer, Ulrich M. Zissler, Carsten B. Schmidt-Weber, Simon Blank
Summary: This study demonstrated that low-dose allergoid AIT had comparable efficacy to suppress allergic airway inflammation and Th2-type cytokine secretion as high-dose extract AIT, but was less effective in inducing a potentially protective IgG1 response. Combining low-dose allergoid AIT with MCT or MCT and dose-adjusted MPL promoted Th1-inducing mechanisms and robust B-cell activation to counterbalance the allergic Th2 immune response. Conclusion: Low allergen doses induce cellular and humoral mechanisms counteracting Th2-driven inflammation by using allergoids and dose-adjusted adjuvants.
Article
Allergy
Sheriene Moussa Afify, Andreas Regner, Luis F. Pacios, Bart R. Blokhuis, Sebastian A. Jensen, Frank A. Redegeld, Isabella Pali-Schoell, Karin Hufnagl, Rodolfo Bianchini, Sonja Guethoff, Matthias F. Kramer, Alessandro Fiocchi, Zdenek Dvorak, Erika Jensen-Jarolim, Franziska Roth-Walter
Summary: The lozenge formulated with catechin-iron complexes effectively masked IgE binding in milk-allergic children and reduced immune reactivity in mice and allergic subjects. By targeting antigen presenting cells, the lozenge dampened immune activation in a non-specific manner, providing immune resilience against allergic symptoms.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Biotechnology & Applied Microbiology
Alexander Heldner, Matthew D. Heath, Benjamin Schnautz, Sebastian Kotz, Adam Chaker, Matthias F. Kramer, Constanze A. Jakwerth, Ulrich M. Zissler, Carsten B. Schmidt-Weber, Simon Blank
Summary: This study investigated the immunomodulatory effects of the synbiotics Pollagen(R) and Kallergen(R) on grass pollen allergy. The results showed that the synbiotics can downregulate the Th2 immune response in allergic patients and promote the shift towards Th1 and Th17 immune responses.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Food Science & Technology
Johannes Grosch, Antoine Lesur, Stephanie Kler, Francois Bernardin, Gunnar Dittmar, Elisabetta Francescato, Simon J. Hewings, Constanze A. Jakwerth, Ulrich M. Zissler, Matthew D. Heath, Markus Ollert, Matthias F. Kramer, Christiane Hilger, Maria Beatrice Bilo, Carsten B. Schmidt-Weber, Simon Blank
Summary: Allergy to Polistes dominula venom is a significant issue in Southern Europe and may become a threat in other regions. Venom immunotherapy (VIT) is an effective treatment for this allergy. This study compared five different VIT preparations for P. dominula venom allergy in Spain and found that the majority of samples contained comparable levels of major allergens.
Article
Allergy
Jan M. Sobczak, Pascal S. Krenger, Federico Storni, Mona O. Mohsen, Ina Balke, Gunta Resevica, Matthew D. Heath, Thalia Carreno L. Velazquez, Matthias F. Kramer, Callum J. W. Scott, Murray A. Skinner, Andris Zeltins, Thomas M. Kundig, Monique Vogel, Martin F. Bachmann
Summary: A novel vaccine candidate (VLP Peanut) based on virus-like particles (VLPs) has been developed for the treatment of peanut allergy. The vaccine has shown to be highly immunogenic and effective in preventing and treating severe reactions caused by peanut allergy in mouse models. These findings suggest that VLP Peanut holds promise as a breakthrough immunotherapy vaccine candidate for peanut allergy.
Article
Allergy
P. J. de Kam, S. Zielen, J. A. Bernstein, U. Berger, M. Berger, M. Cuevas, D. Cypcar, A. Fuhr-Horst, W. A. Greisner, M. Jandl, S. Lassmann, M. Worm, J. Matz, E. Sher, C. Smith, G. C. Steven, R. Moesges, M. H. Shamji, L. DuBuske, F. Borghese, K. Oluwayi, T. Zwingers, M. Seybold, O. Armfield, M. D. Heath, S. J. Hewings, M. F. Kramer, M. A. Skinner
Summary: The study evaluated the efficacy and safety of a modified grass allergen subcutaneous immunotherapy for grass-pollen allergic rhinitis/rhinoconjunctivitis. The results showed clinically relevant and statistically significant improvements in symptom and medication scores, as well as a good safety profile.
Article
Allergy
Pascal S. Krenger, Romano Josi, Jan Sobczak, Thalia L. C. Velazquez, Ina Balke, Murray A. Skinner, Matthias F. Kramer, Callum J. W. Scott, Simon Hewings, Matthew D. Heath, Andris Zeltins, Martin F. Bachmann
Summary: This study demonstrates that prokaryotic RNA encapsulated within VLP Peanut and the density of Ara h 2 antigen on viral particles are key contributors to the immunogenicity and protective capacity of the vaccine.
Article
Allergy
Karl-Christian Bergmann, Jennifer Raab, Anke Graessel, Thomas Zwingers, Sylvia Becker, Sebastian Kugler, Torsten Zuberbier, Franziska Roth-Walter, Matthias F. Kramer, Erika Jensen-Jarolim
Summary: This study demonstrated the significant improvement in symptoms and immune resilience in cat allergic patients after targeted micronutrition with the holoBLG lozenge.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Allergy
Karl-Christian Bergmann, Jennifer Raab, Linda Krause, Sylvia Becker, Sebastian Kugler, Torsten Zuberbier, Franziska Roth-Walter, Erika Jensen-Jarolim, Matthias F. Kramer, Anke Graessel
Meeting Abstract
Allergy
Lawrence M. DuBuske, Stefan Zielen, Jonathan A. Bernstein, Uwe Berger, Markus Berger, Mandy Cuevas, David Cypcar, Annette Fuhr-Horst, William A. Greisner, Margret Jandl, Sabine Lassmann, Margitta Worm, Jonathan Matz, Ellen Sher, Chris Smith, Gary C. Steven, Kemi Oluwayi, Marion Seybold, Matthias F. Kramer, Murray A. Skinner, Pieter-Jan de Kam
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Meeting Abstract
Allergy
Pascal Krenger, Federico Storni, Jan Sobczak, Andris Zeltins, Matthew D. Heath, Matthias F. Kramer, Murray A. Skinner, Thomas M. Kuendig, Martin F. Bachmann
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Meeting Abstract
Allergy
Lawrence DuBuske, Stefan Zielen, Jonathan Bernstein, Uwe Berger, Markus Berger, Mandy Cuevas, David Cypcar, Annette Fuhr-Horst, William Greisner, Margret Jandl, Sabine Lassmann, Margitta Worm, Jonathan Matz, Ellen Sher, Chris Smith, Gary Steven, Kemi Oluwayi, Marion Seybold, Matthias Kramer, Murray Skinner, Pieter-Jan de Kam
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Meeting Abstract
Allergy
Mohamed Shamji, Janice Layhadi, Paul Turner, Nandinee Patel, Rebecca Parkin, Kemi Oluwayi, Olesya Rusyn, Murray Skinner, Matthew Heath, Matthias Kramer, Pieter-Jan de Kam
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)