Article
Immunology
Nagendrakumar Balasubramanian Singanallur, Aldo Dekker, Phaedra Lydia Eble, Froukje van Hemert-Kluitenberg, Klaas Weerdmeester, Jacquelyn J. Horsington, Wilna Vosloo
Summary: Vaccination is a key tool in controlling and eradicating foot-and-mouth disease, but the effectiveness of vaccines against different virus strains needs to be considered. This study examined the protective effects of the O3039 vaccine strain against a new virus variant, showing promising results in terms of protection.
Article
Immunology
Xuesong Xu, Yi Hong, Erjing Chen, Yaping Wang, Biao Ma, Jiali Li, Wei Su, Yuxin Zhou, Mingzhou Zhang
Summary: This study discusses the inhibitory abilities of antibodies induced by primary and booster vaccines against different strains of SARS-CoV-2. The results show that homologous inactivated vaccines have the strongest inhibitory effects on the wild-type strain, but exhibit resistance against B.1.351, B.1.617.2, and B.1.1.529 mutants. Heterologous booster vaccination can significantly restore humoral immune responses and generate stronger antibody responses against various mutant strains.
Article
Immunology
Seong Yun Hwang, Sung Ho Shin, Hyun Mi Kim, SeHee Shin, Min Ja Lee, Su-Mi Kim, Jong-Soo Lee, Jong-Hyeon Park
Summary: In this study, a potent vaccine strain was developed to provide complete protection against FMD type O viruses of Southeast Asia, Middle East-South Asia, and Cathay topotypes. Mice immunized with the experimental vaccines were fully protected against these viruses. PA2-VP1 showed higher neutralizing antibody titers than JC-VP1 in early vaccination phase in pigs.
Article
Biotechnology & Applied Microbiology
Nasamon Wanlapakorn, Nungruthai Suntronwong, Harit Phowatthanasathian, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Chompoonut Auphimai, Donchida Srimuan, Thaksaporn Thatsanatorn, Suvichada Assawakosri, Sitthichai Kanokudom, Yong Poovorawan
Summary: This study assessed the reactogenicity and immunogenicity of heterologous regimens for COVID-19 vaccines in healthy Thai adults. The adverse events were mild and well tolerated overall. Heterologous regimens showed higher antibody responses and neutralizing activities. Spike-specific IgA response was detected only in the heterologous group. The interferon gamma response was detected in both heterologous groups after two-dose vaccination.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Microbiology
Zhipeng Zhang, Dasheng Wang, Yiyang Yao, Jiayu Yang, Zhangping Yang, Yi Yang
Summary: This study comprehensively analyzed T-cell responses in cows vaccinated against foot-and-mouth disease (FMD) using multi-parameter flow cytometry. The results revealed a significant reduction in CD4, CD8, and gamma delta T cells, and a marked increase in the proportion of CD4(+)CD8(+) double-positive (DP) T cells following FMD vaccine inoculation. Cows with high vaccine potency exhibited a higher proportion of CD4(+)CD8(+) DP T cells post-vaccination. These groundbreaking findings shed light on the latent function of CD4(+)CD8(+) DP T cells in FMD vaccine-induced immune protection and established a novel method for evaluating FMD vaccine efficacy based on T-cell responses.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Seokwon Shin, Hyeong Won Kim, Mi-Kyeong Ko, So Hui Park, Su-Mi Kim, Jong-Hyeon Park, Min Ja Lee
Summary: Glycyrrhizic acid, extracted from licorice roots, has been found to induce innate immune response and enhance early, mid-, and long-term immunity. Adding glycyrrhizic acid as an adjuvant to the FMD bivalent vaccine can promote immune reactions by increasing the expression of immunoregulatory genes. This novel adjuvant has the potential to address the limitations of commercialized FMD vaccines.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Otavio T. Ranzani, Matt D. T. Hitchings, Rosana Leite de Melo, Giovanny V. A. de Franca, Cassia de Fatima R. Fernandes, Margaret L. Lind, Mario Sergio Scaramuzzini Torres, Daniel Henrique Tsuha, Leticia C. S. David, Rodrigo F. C. Said, Maria Almiron, Roberto D. de Oliveira, Derek A. T. Cummings, Natalie E. Dean, Jason R. Andrews, Albert I. Ko, Julio Croda
Summary: This study investigates the effectiveness of COVID-19 vaccine boosters following a primary series of CoronaVac vaccination. The study shows that boosters provide protection against severe disease, with higher effectiveness from a BNT162b2 booster compared to a CoronaVac booster. The study estimates the vaccine effectiveness (VE) of homologous and heterologous (BNT162b2) booster doses in adults who received two doses of CoronaVac in Brazil during the Omicron wave. The results indicate a VE of 8.6% for symptomatic disease and 56.8% for severe COVID-19 after receiving a homologous booster, while the VE for symptomatic disease is 56.8% and for severe COVID-19 is 86.0% after receiving a heterologous booster. Waning effectiveness against severe COVID-19 is observed only after 120 days in individuals who received a homologous booster. Heterologous boosters might be preferable for individuals who have completed a primary series of inactivated vaccines.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Kanami Tamura, Mai Kohnoe, Ayako Takashino, Kyousuke Kobayashi, Satoshi Koike, Lovkesh Karwal, Shigeru Fukuda, Fue Vang, Subash C. Das, Hansi J. Dean
Summary: The study demonstrates that TAK-021 can provide protection against different sub-genogroups of EV71 in mice, inducing neutralizing antibodies and reducing the risk of viral infection.
Article
Immunology
W. A. Gayan Chathuranga, Chamith Hewawaduge, N. A. Nadeeka Nethmini, Tae-Hwan Kim, Ju Hun Kim, Young-Hoon Ahn, In-Joong Yoon, Sung-Sik Yoo, Jong-Hyeon Park, Jong-Soo Lee
Summary: This study developed two multiepitope recombinant proteins as potential vaccine candidates for foot-and-mouth disease. The results showed that these proteins effectively induced immune responses and protected animals from the virus. By using appropriate adjuvants, the protective efficacy of the vaccine candidates can be enhanced, providing a method for developing effective and safe vaccines for the prevention and control of foot-and-mouth disease.
Article
Immunology
Yimei Cao, Kun Li, Xiangchuan Xing, Huifang Bao, Nana Huang, Guoqiang Zhu, Xingwen Bai, Pu Sun, Yuanfang Fu, Pinghua Li, Jing Zhang, Xueqing Ma, Dong Li, Zaixin Liu, Zengjun Lu
Summary: The study selected O/XJ/CHA/2017 as a promising vaccine strain candidate for foot-and-mouth disease, showing the highest immunogenicity in pigs, cattle, and sheep by NA-ELISA and VNT. Cross-neutralization analysis indicated its broad antigen spectrum and antigenic match with other strains, with a significant correlation between NA-ELISA and VNT results.
Article
Infectious Diseases
Laetitia Canini, Sandra Blaise-Boisseau, Antonello Di Nardo, Andrew E. Shaw, Aurore Romey, Anthony Relmy, Cindy Bernelin-Cottet, Anne-Laure Salomez, Andy Haegeman, Hussaini Ularamu, Hafsa Madani, Bruno Lalidia Ouoba, Habibata Lamouni Zerbo, Mamadou Lamarana Souare, Cyprien Yapi Boke, Ibrahim Eldaghayes, Abdunaser Dayhum, Moina Hasni Ebou, Nabil Abouchoaib, Soufien Sghaier, David Lefebvre, Kris DeClercq, Valerie Milouet, Emiliana Brocchi, Giulia Pezzoni, Charles Nfon, Donald King, Benoit Durand, Nick Knowles, Labib Bakkali-Kassimi, Souheyla Benfrid
Summary: This study investigates the phylodynamics of foot-and-mouth disease virus (FMDV) in Africa and Western Asia, highlighting the importance of surveillance and control measures.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Sang-Hyun Park, Seo-Yong Lee, Jae-Seok Kim, Ah-Young Kim, Sun-Young Park, Ji-Hye Lee, Mijung Lee, Hyejin Kim, Sim-In Lee, Na-Young Kang, Jung-Won Park, Su-Mi Kim, Jong-Hyeon Park, Young-Joon Ko
Summary: This study introduces a bivalent vaccine developed in South Korea for foot-and-mouth disease (FMD), which successfully scaled up two virus strains and prepared a highly effective vaccine through optimized conditions. The experimental bivalent vaccine shows a broad spectrum of high neutralizing antibody titers, providing protection against FMDV types O and A circulating in South Korea and neighboring countries.
Article
Multidisciplinary Sciences
Zachary R. Sia, Xuedan He, Ali Zhang, Jann C. Ang, Shuai Shao, Amal Seffouh, Wei-Chiao Huang, Michael R. D'Agostino, Amir Teimouri Dereshgi, Sambhara Suryaprakash, Joaquin Ortega, Hanne Andersen, Matthew S. Miller, Bruce A. Davidson, Jonathan F. Lovell
Summary: The study evaluated a vaccine adjuvant system consisting of immunogenic liposomes, which can enhance antigen delivery and immune responses. It was found that this system induced strong antibody responses and provided protection in mice following infection challenges. Furthermore, binding different surface antigens to liposomes induced specific antibody responses in mice and protected against challenging viruses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Seong Yun Hwang, Sung Ho Shin, Sung-Han Park, Min Ja Lee, Su-Mi Kim, Jong-Soo Lee, Jong-Hyeon Park
Summary: This study successfully developed a vaccine against different topotypes of the fatal foot-and-mouth disease virus. The experimental vaccine was found to effectively protect mice against infection from different topotype viruses, and induced specific immune responses in animals.
Review
Immunology
Zhimin Lu, Shu Yu, Weijun Wang, Wenxian Chen, Xinyan Wang, Keke Wu, Xiaowen Li, Shuangqi Fan, Hongxing Ding, Lin Yi, Jingding Chen
Summary: FMD is a serious disease that affects the global livestock industry, and the development of vaccines plays a key role in controlling outbreaks of FMD.
