Article
Biochemistry & Molecular Biology
Olivier Duriez, Yohan Sassi, Chloe Le Gall-Ladeveze, Lea Giraud, Robert Straughan, Lise Dauverne, Anna Terras, Thierry Boulinier, Remi Choquet, Anne van de Wiele, Julien Hirschinger, Jean-Luc Guerin, Guillaume Le Loc'h
Summary: A study found that terrestrial birds infected with highly pathogenic avian influenza (HPAI) virus exhibit immobility behavior during the breeding season, which may reduce the risk of virus transmission. However, these infections pose a threat to endangered vulture species, raising concerns about their resistance to the virus.
Article
Multidisciplinary Sciences
Mariana Leguia, Alejandra Garcia-Glaessner, Breno Munoz-Saavedra, Diana Juarez, Patricia Barrera, Carlos Calvo-Mac, Javier Jara, Walter Silva, Karl Ploog, Lady Amaro, Paulo Colchao-Claux, Christine K. Johnson, Marcela M. Uhart, Martha I. Nelson, Jesus Lescano
Summary: Highly pathogenic avian influenza A/H5N1 viruses have invaded the Americas and pose a threat to wildlife, poultry, and humans. The HPAI/H5N1 viruses in Peru have genetic reassortment between Eurasian and American lineages, emphasizing the need for surveillance and control measures.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Yu Ye, Huiying Fan, Qi Li, Zhen Zhang, Peisi Miao, Jun Zhu, Jie Liu, Jie Zhang, Ming Liao
Summary: This study provides a comprehensive analysis of the proteome response in Muscovy duck lung tissue during H5N1 avian influenza virus infection. The findings suggest that the infection mechanism and disease progression of H5N1 viruses may be related to specific pathways and protein expressions. The study reveals differences in host immune response between different strains of the H5N1 virus and indicates the involvement of the Akt/mTOR/p70S6K pathway in the host response to H5N1 viruses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Fatou T. Lo, Bianca Zecchin, Alpha A. Diallo, Racky O. Ba, Luca Tassoni, Aida Diop, Moussa Diouf, Mayekor Diouf, Yacine N. Samb, Ambra Pastori, Federica Gobbo, Francesca Ellero, Mariame Diop, Modou M. Lo, Mame N. Diouf, Mathioro Fall, Amadou A. Ndiaye, Adji M. Gaye, Medoune Badiane, Mbargou Lo, Babacor N. Youm, Ibrahima Ndao, Marius Niaga, Calogero Terregino, Boly Diop, Youssou Ndiaye, Angelique Angot, Ismaila Seck, Mamadou Niang, Baba Soumare, Alice Fusaro, Isabella Monne
Summary: In January 2021, the emergence of highly pathogenic avian influenza virus A(H5N1) was reported in Senegal, detected on a poultry farm and in great white pelicans in the Djoudj National Bird Sanctuary. This provides evidence of new transcontinental spread of H5N1 from Europe to Africa.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Mabusetsa R. J. Makalo, William G. Dundon, Tirumala B. K. Settypalli, Sneha Datta, Charles E. Lamien, Giovanni Cattoli, Moeketsi S. Phalatsi, Relebohile J. Lepheana, Mpaliseng Matlali, Relebohile G. Mahloane, Marosi Molomo, Palesa C. Mphaka
Summary: In May 2021, Lesotho reported its first outbreak of highly pathogenic avian influenza (HPAI) caused by H5N1 subtype. The virus showed high genetic similarity with A/H5N1 viruses identified in Nigeria and Senegal. This discovery has significant implications for disease management and food security in the region.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Idrissa Nonmon Sanogo, Fidelia Djegui, Yao Akpo, Corneille Gnanvi, Gabriel Dupre, Adam Rubrum, Trushar Jeevan, Pamela McKenzie, Richard J. Webby, Mariette F. Ducatez
Summary: Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses were detected in poultry in southern Benin in August 2021. The isolates were genetically similar to H5N1 viruses of clade 2.3.4.4b isolated during the same period in Africa and Europe. Evidence for 2 separate introductions of these viruses into Benin was also found.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Natalie Moyen, Md. Ahasanul Hoque, Rashed Mahmud, Mahmudul Hasan, Sudipta Sarkar, Paritosh Kumar Biswas, Hossain Mehedi, Joerg Henning, Punam Mangtani, Meerjady Sabrina Flora, Mahmudur Rahman, Nitish C. Debnath, Mohammad Giasuddin, Tony Barnett, Dirk U. Pfeiffer, Guillaume Fournie
Summary: Live animal markets are known hotspots for zoonotic disease emergence, and trading networks play a crucial role in disease spread dynamics. In Bangladesh, live poultry trading networks promote viral strain co-circulation, with upstream transmission nodes significantly impacting viral prevalence in markets. Disease control interventions should target network structures, tailored to local characteristics for effectiveness.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Hongbo Zhang, Yanfeng Yao, Yan Li, Jianjun Chen, Ze Chen
Summary: This study isolated multiple H5N1 strains from water samples in Dongting Lake and lakeside backyard poultry, and genetic analysis revealed a diversified genome constellation. The genetic characteristics of some viruses from water samples were similar to those from lakeside poultry. Pathogenic experiments showed that selected isolates were highly pathogenic in SPF chickens but had varied virulence in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Xianliang Ke, Zhongzi Yao, Yangyu Tang, Mengting Yang, Yong Li, Guoxiang Yang, Jing Chen, Guang Chen, Wei Feng, Hesong Zheng, Quanjiao Chen
Summary: In this study, the whole-genomes of six H5N1 viruses obtained from dead or rescued wild birds in Hubei Province were analyzed. These viruses were classified into two genotypes and had different evolutionary trajectories compared to previously reported H5N1 viruses in China. The analysis revealed extensive reassortment events between highly pathogenic and low-pathogenic avian influenza viruses. Furthermore, amino acid analysis suggested a potential threat of H5N1 viruses to public health. The findings of this study provide valuable insights into the prevalence patterns of H5N1 viruses in wild birds and contribute to the understanding of the viral population data in central China.
MICROBIOLOGY SPECTRUM
(2022)
Letter
Immunology
Francois-Xavier Briand, Florent Souchaud, Isabelle Pierre, Veronique Beven, Edouard Hirchaud, Fabrice Herault, Rene Planel, Angelina Rigaudeau, Sibylle Bernard-Stoecklin, Sylvie Van der Werf, Bruno Lina, Guillaume Gerbier, Nicolas Eterradossi, Audrey Schmitz, Eric Niqueux, Beatrice Grasland
Summary: During December 2022, a domestic cat living near a duck farm infected by a closely related virus in France was found to be infected with the highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus. Enhanced surveillance of symptomatic domestic carnivores in contact with infected birds is recommended to prevent further spread to mammals and humans.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Wendy Puryear, Kaitlin Sawatzki, Nichola Hill, Alexa Foss, Jonathon J. Stone, Lynda Doughty, Dominique Walk, Katie Gilbert, Maureen Murray, Elena Cox, Priya Patel, Zak Mertz, Stephanie Ellis, Jennifer Taylor, Deborah Fauquier, Ainsley Smith, Robert A. DiGiovanni Jr, Adriana van de Guchte, Ana Silvia Gonzalez-Reiche, Zain Khalil, Harm van Bakel, Mia K. Torchetti, Kristina Lantz, Julianna B. Lenoch, Jonathan Runstadler
Summary: We report the spread of highly pathogenic avian influenza A(H5N1) in marine mammals in the northeastern United States, which is concurrent with the presence of H5N1 in wild birds in the same area. Our findings highlight the importance of monitoring both wild coastal birds and marine mammals in assessing the potential for an influenza A virus pandemic.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Jingman Tian, Xiaoli Bai, Minghui Li, Xianying Zeng, Jia Xu, Peng Li, Miao Wang, Xingdong Song, Zhiguo Zhao, Guobin Tian, Liling Liu, Yuntao Guan, Yanbing Li, Hualan Chen
Summary: Since 2020, highly pathogenic avian influenza subtype H5N1 clade 2.3.4.4b virus has spread globally, causing large-scale avian influenza outbreaks. In China, 17 highly pathogenic H5N1 avian influenza viruses were isolated from wild birds, belonging to genotypes G07 and G10 from eastern Asia and Russia, respectively. These viruses were moderately pathogenic in mice but highly lethal in ducks. The H5/H7 trivalent vaccine provided complete protection against the H5N1 virus challenge in chickens.
EMERGING INFECTIOUS DISEASES
(2023)
Letter
Immunology
Jolianne M. Rijks, Hanna Hesselink, Pim Lollinga, Renee Wesselman, Pier Prins, Eefke Weesendorp, Marc Engelsma, Rene Heutink, Frank Harders, Marja Kik Harry Rozendaal, Hans van den Kerkhof, Nancy Beerens
Summary: In the Netherlands, infection with highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b was detected in two red fox cubs exhibiting neurological signs, which is related to avian influenza viruses found in wild birds in the same area.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Agriculture, Multidisciplinary
Liu Li-ling, Yang Huan-liang, Guo Fu-sheng, Wang Xiu-rong, Deng Guo-hua, Shi Jian-zhong, Tian Guo-bin, Zeng Xian-ying
Summary: In the past decade, global surveillance has been conducted to monitor highly pathogenic avian influenza (HPAI) infection. However, there have been limited studies on the epidemiology of avian influenza in the Democratic People's Republic of Korea (DPRK). From 2013 to 2014, outbreaks of HPAI H5N1 viruses were detected in domestic poultry in DPRK. Phylogenetic analysis revealed that the viruses were introduced by migratory birds and then spread to neighboring chicken farms.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Immunology
Konstantin Andreev, Jeremy C. Jones, Patrick Seiler, Ahmed Kandeil, Jasmine C. M. Turner, Subrata Barman, Adam M. Rubrum, Richard J. Webby, Elena A. Govorkova
Summary: The antiviral susceptibility of currently circulating highly pathogenic avian influenza A(H5N1) viruses was assessed using genotypic and phenotypic approaches. The majority of the viruses retain susceptibility to antiviral drugs, but novel mutations have been identified that reduce the inhibitory effects of certain drugs.
JOURNAL OF INFECTIOUS DISEASES
(2023)