Review
Immunology
Animesh Sarker, Nidhi Dhama, Rinkoo Devi Gupta
Summary: Dengue is a common viral infection transmitted by mosquitoes in tropical countries. While the initial infection is usually mild, secondary infections can be severe and potentially fatal. The antibodies produced in response to vaccination or primary infection are often weakly neutralizing and can increase the risk of antibody-dependent enhancement (ADE) during subsequent infections.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jordan H. Salas, Richard A. Urbanowicz, Johnathan D. Guest, Nicole Frumento, Alexis Figueroa, Kaitlyn E. Clark, Zhenyong Keck, Vanessa M. Cowton, Sarah J. Cole, Arvind H. Patel, Thomas R. Fuerst, Heidi E. Drummer, Marian Major, Alexander W. Tarr, Jonathan K. Ball, Mansun Law, Brian G. Pierce, Steven K. H. Foung, Justin R. Bailey
Summary: This study describes the selection and validation of a genetically and antigenically diverse reference panel of 15 HCV pseudoparticles (HCVpps) for neutralization assays. It suggests that measuring neutralizing breadth of HCV antibodies should involve viruses spanning multiple tiers of neutralization sensitivity rather than panels selected solely for genetic diversity.
Article
Immunology
Christine A. Shaw, Allison August, Stephan Bart, Peta-Gay Jackson Booth, Conor Knightly, Trevor Brasel, Scott C. Weaver, HongHong Zhou, Lori Panther
Summary: A phase 1 study evaluated the safety and immunogenicity of an mRNA vaccine candidate (mRNA-1388) against Chikungunya virus (CHIKV) in healthy participants. The results showed that mRNA-1388 was well tolerated and induced substantial and long-lasting neutralizing antibody responses.
Review
Virology
Maryam Shafaati, Milad Zandi
Summary: This article focuses on the current state of human monkeypox infection outbreak, research & development of immune responses, and clinical interventions to prevent and treat human monkeypox virus and other human poxviruses.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Usha K. Nivarthi, Jesica Swanstrom, Matthew J. Delacruz, Bhumi Patel, Anna P. Durbin, Steve S. Whitehead, Beth D. Kirkpatrick, Kristen K. Pierce, Sean A. Diehl, Leah Katzelnick, Ralph S. Baric, Aravinda M. de Silva
Summary: The study showed that the TV003 vaccine can stimulate balanced and serotype-specific neutralizing antibody responses to all four serotypes of dengue virus. Most of the 21 dengue-naive individuals in the study developed serotype-specific neutralizing antibodies to 3 or 4 DENV serotypes after vaccination.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Vincent Dussupt, Kayvon Modjarrad, Shelly J. Krebs
Summary: The unprecedented Zika outbreak in the Americas from 2015-2016 led to global concern and accelerated the deployment of vaccine and therapeutic countermeasures. Several potent neutralizing antibodies against Zika and related flaviviruses have been discovered in recent years. Structure-based approaches have helped identify species-specific and cross-protective epitopes with therapeutic value.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Laura J. White, Ellen F. Young, Mark J. Stoops, Sandra R. Henein, Elizabeth C. Adams, Ralph S. Baric, Aravinda M. de Silva
Summary: The four serotypes of dengue virus infect millions of people each year, making the development of vaccines challenging. TAK-003, a tetravalent live attenuated dengue vaccine candidate, induces high levels of neutralizing antibodies. The vaccine primarily generates neutralizing antibodies targeting unique epitopes on DENV2, while the levels of neutralizing antibodies against DENV1, DENV3, and DENV4 are lower.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Virology
Guochao Liao, Hungyan Lau, Zhongqiu Liu, Chinyu Li, Zeping Xu, Xiaoxiao Qi, Yu Zhang, Qian Feng, Runze Li, Xinyu Deng, Yebo Li, Qing Zhu, Sisi Zhu, Hua Zhou, Hudan Pan, Xingxing Fan, Yongchao Li, Dan Li, Liqing Chen, Bixia Ke, Zhe Cong, Qi Lv, Jiangning Liu, Dan Liang, An'an Li, Wenshan Hong, Linlin Bao, Feng Zhou, Hongbin Gao, Shi Liang, Bihong Huang, Miaoli Wu, Chuan Qin, Changwen Ke, Liang Liu
Summary: This study developed a novel rAAV5-based vaccine that provides long-term protective immunity against SARS-CoV-2 and its variants. The vaccine induced a robust immune response in mice, with high levels of neutralizing antibodies and functional T-cell responses. Importantly, the vaccine protected mice from SARS-CoV-2 infection in both the upper and lower respiratory tracts, and showed no signs of safety concerns. This vaccine has significant potential for development as a prophylactic vaccination to help end the global pandemic.
Article
Multidisciplinary Sciences
Noemia S. Lima, Maryam Musayev, Timothy S. Johnston, Danielle A. Wagner, Amy R. Henry, Lingshu Wang, Eun Sung Yang, Yi Zhang, Kevina Birungi, Walker P. Black, Sijy O'Dell, Stephen D. Schmidt, Damee Moon, Cynthia G. Lorang, Bingchun Zhao, Man Chen, Kristin L. Boswell, Jesmine Roberts-Torres, Rachel L. Davis, Lowrey Peyton, Sandeep R. Narpala, Sarah O'Connell, Leonid Serebryannyy, Jennifer Wang, Alexander Schrager, Chloe Adrienna Talana, Geoffrey Shimberg, Kwanyee Leung, Wei Shi, Rawan Khashab, Asaf Biber, Tal Zilberman, Joshua Rhein, Sara Vetter, Afeefa Ahmed, Laura Novik, Alicia Widge, Ingelise Gordon, Mercy Guech, I-Ting Teng, Emily Phung, Tracy J. Ruckwardt, Amarendra Pegu, John Misasi, Nicole A. Doria-Rose, Martin Gaudinski, Richard A. Koup, Peter D. Kwong, Adrian B. McDermott, Sharon Amit, Timothy W. Schacker, Itzchak Levy, John R. Mascola, Nancy J. Sullivan, Chaim A. Schramm, Daniel C. Douek
Summary: Infection with SARS-CoV-2 variants leads to protective humoral immunity against other variants. The molecular basis for this cross-protection is not fully understood. This study reveals that infection with different variants elicits similar antibody responses and convergent V gene usage, which may explain the continued efficacy of vaccines based on a single ancestral variant.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Yueh-Ming Loo, Patrick M. McTamney, Rosalinda H. Arends, Michael E. Abram, Anastasia A. Aksyuk, Seme Diallo, Daniel J. Flores, Elizabeth J. Kelly, Kuishu Ren, Richard Roque, Kim Rosenthal, Katie Streicher, Kevin M. Tuffy, Nicholas J. Bond, Owen Cornwell, Jerome Bouquet, Lily Cheng, James Dunyak, Yue Huang, Anton Rosenbaum, Venkatesh Pilla Reddy, Hanne Andersen, Robert H. Carnahan, James E. Crowe, Ana Kuehne, Andrew S. Herbert, John M. Dye, Helen Bright, Nicole L. Kallewaard, Menelas N. Pangalos, Mark T. Esser
Summary: AZD7442, a combination of two monoclonal antibodies, has the potential to prevent and treat COVID-19 by neutralizing the SARS-CoV-2 virus. It has shown encouraging results in preventing infection and accelerating virus clearance in animal models. The ongoing phase 1 study has also demonstrated its ability to provide long-lasting protection in healthy participants. This research is significant in providing additional options for COVID-19 prevention and treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Microbiology
David R. Martinez, Stefan W. Metz, Ralph S. Baric
Summary: This review outlines the challenges and advantages of developing a safe, effective, and balanced DENV vaccine, with the aim of providing uniform protection against all four serotypes. While T cell biology plays an important role in establishing protective immunity, the review focuses on B cell responses. Understanding the immune correlates of protection against DENV infection is crucial for informing the development of a vaccine that can offer long-term, uniform protection.
CELL HOST & MICROBE
(2021)
Article
Virology
Giuditta De Lorenzo, Rapeepat Tandavanitj, Jennifer Doig, Chayanee Setthapramote, Monica Poggianella, Ricardo Sanchez-Velazquez, Hannah E. Scales, Julia M. Edgar, Alain Kohl, James Brewer, Oscar R. Burrone, Arvind H. Patel
Summary: The study developed ZIKV subunit and virus-like particle (VLP)-based vaccines, which induced antibodies with a higher capacity to neutralize virus infection and protected animals from lethal challenge with both the African and Asian lineages of ZIKV. The engineered immunogens reduced the potential to induce antibody-dependent enhancement (ADE) of infection and showed promising efficacy in comparison with the wild-type derivatives.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nuno Taveira, Ines Figueiredo, Rita Calado, Francisco Martin, Ines Bartolo, Jose M. Marcelino, Pedro Borrego, Fernando Cardoso, Helena Barroso
Summary: Developing immunogens that can elicit broadly neutralizing antibodies (bNAbs) is crucial for the development of an effective HIV vaccine. In this study, a prime-boost vaccination strategy using vaccinia virus expressing the gp120 envelope glycoprotein of HIV-2 and a polypeptide comprising specific regions of the envelope glycoprotein was shown to elicit bNAbs against both HIV-1 and HIV-2. The findings suggest that a chimeric envelope glycoprotein containing specific regions from both viruses could be a potential vaccine immunogen to target neutralizing epitopes in both HIV-1 and HIV-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Javier Diez-Domingo, Xavier Saez-Llorens, Miguel A. Rodriguez-Weber, Cristina Epalza, Archana Chatterjee, Cheng-Hsun Chiu, Chien-Yu Lin, Andrea A. Berry, Federico Martinon-Torres, Fernando Baquero-Artigao, Joanne M. Langley, Jose T. Ramos Amador, Joseph B. Domachowske, Li-Min Huang, Nan-Chang Chiu, Susanna Esposito, Philippe Moris, Thi Lien-Anh Nguyen, Vanja Nikic, Wayne Woo, Yingjun Zhou, Ilse Dieussaert, Amanda Leach, Antonio Gonzalez Lopez, Nicolas Vanhoutte
Summary: This study tested a new candidate RSV vaccine in toddlers who had a previous RSV infection. The vaccine was effective in preventing RSV-related illnesses and triggered an antibody response that could neutralize the virus. No vaccine-related serious adverse events or RSV-related hospitalizations were reported during the study.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Daniel J. Sheward, Tandile Hermanus, Ben Murrell, Nigel Garrett, Salim S. Abdool Karim, Lynn Morris, Penny L. Moore, Carolyn Williamson
Summary: The development of broadly neutralizing antibodies (bNAbs) to HIV and other diverse pathogens may require the use of multiple immunogens. This study characterizes the antibody responses in individuals coinfected with multiple HIV variants, revealing interference and the potential role of conserved neutralizing epitopes in guiding broad antibody responses.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Janet C. Lindow, Paul R. Dohrmann, Charles S. McHenry
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Microbiology
Janet C. Lindow, Elsio A. Wunder, Stephen J. Popper, Jin-na Min, Praveen Mannam, Anup Srivastava, Yi Yao, Kathryn P. Hacker, Khadir Raddassi, Patty J. Lee, Ruth R. Montgomery, Albert C. Shaw, Jose E. Hagan, Guilherme C. Araujo, Nivison Nery, David A. Relman, Charles C. Kim, Mitermayer G. Reis, Albert I. Ko
Article
Computer Science, Software Engineering
Nivison Ruy Rocha Nery, Daniela Barreiro Claro, Janet C. Lindow
Article
Infectious Diseases
Carolina Lessa-Aquino, Janet C. Lindow, Arlo Randall, Elsio Wunder, Jozelyn Pablo, Rie Nakajima, Algis Jasinskas, Jaqueline S. Cruz, Alcineia O. Damlao, Nivison Nery, Guilherme S. Ribeiro, Federico Costa, Jose E. Hagan, Mitermayer Galvao Reis, Albert I. Ko, Marco Alberto Medeiros, Philip L. Felgner
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Immunology
Stephen J. Popper, Fiona R. Strouts, Janet C. Lindow, Henry K. Cheng, Magelda Montoya, Angel Balmaseda, Anna P. Durbin, Stephen S. Whitehead, Eva Harris, Beth D. Kirkpatrick, David A. Relman
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Infectious Diseases
Andrew G. Schneider, Arnau Casanovas-Massana, Kathryn P. Hacker, Elsio A. Wunder, Mike Begon, Mitermayer G. Reis, James E. Childs, Federico Costa, Janet C. Lindow, Albert I. Ko
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Biochemical Research Methods
Carolina Lessa-Aquino, Elsio A. Wunder, Janet C. Lindow, Camila B. Rodrigues, Jozelyn Pablo, Rie Nakajima, Algis Jasinskas, Li Liang, Mitermayer G. Reis, Albert I. Ko, Marco A. Medeiros, Philip L. Felgner
JOURNAL OF PROTEOME RESEARCH
(2015)
Article
Virology
Daniela Weiskopf, Michael A. Angelo, Derek J. Bangs, John Sidney, Sinu Paul, Bjoern Peters, Aruna D. de Silva, Janet C. Lindow, Sean A. Diehl, Stephen Whitehead, Anna Durbin, Beth Kirkpatrick, Alessandro Sette
JOURNAL OF VIROLOGY
(2015)
Article
Multidisciplinary Sciences
Brian T. Backstedt, Ozlem Buyuktanir, Janet Lindow, Elsio A. Wunder, Mitermayer G. Reis, Sahar Usmani-Brown, Michel Ledizet, Albert Ko, Utpal Pal
Article
Public, Environmental & Occupational Health
Janet C. Lindow, Annie J. Tsay, Ruth R. Montgomery, Eliana A. G. Reis, Elsio A. Wunder, Guilherme Araujo, Nivison R. R. Nery, Subhasis Mohanty, Albert C. Shaw, Patty J. Lee, Mitermayer G. Reis, Albert I. Ko
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2019)
Article
Health Care Sciences & Services
Mark B. Schure, Janet C. Lindow, John H. Greist, Paul A. Nakonezny, Sandra J. Bailey, William L. Bryan, Matthew J. Byerly
JOURNAL OF MEDICAL INTERNET RESEARCH
(2019)
Article
Psychology, Developmental
Janet C. Lindow, Jennifer L. Hughes, Charles South, Abu Minhajuddin, Luis Gutierrez, Elizabeth Bannister, Madhukar H. Trivedi, Matthew J. Byerly
JOURNAL OF ADOLESCENT HEALTH
(2020)
Article
Psychology, Developmental
Jacqueline R. Anderson, Michael Killian, Anne Fuller, Jennifer L. Hughes, Matthew Byerly, Janet Lindow, A. John Rush, Madhukar H. Trivedi
Summary: This study confirmed the strong internal consistency and construct validity of the Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire, validating its effectiveness in a non-clinical population. The questionnaire is shown to be a reliable tool for assessing the quality of life and life satisfaction in adolescents.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2022)
Article
Psychiatry
Janet C. Lindow, Jennifer L. Hughes, Charles South, Luis Gutierrez, Elizabeth Bannister, Madhukar H. Trivedi, Matthew J. Byerly
ARCHIVES OF SUICIDE RESEARCH
(2020)
Article
Psychiatry
Paul A. Nakonezny, Janet C. Lindow, T. Scott Stroup, Joseph P. McEvoy, Marvin S. Swartz, Robert A. Rosenheck, Matthew J. Byerly
SCHIZOPHRENIA RESEARCH
(2020)