期刊
VACCINE
卷 31, 期 39, 页码 4220-4222出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2013.03.042
关键词
Recombinant vaccines; Vaccinia virus; Vaccine vectors; Recombinant DNA; DNA cloning
资金
- Intramural NIH HHS [ZIA AI000416-29] Funding Source: Medline
Poxvirus expression vectors were described in 1982 and quickly became widely used for vaccine development as well as research in numerous fields. Advantages of the vectors include simple construction, ability to accommodate large amounts of foreign DNA and high expression levels. Numerous poxvirus-based veterinary vaccines are currently in use and many others are in human clinical trials. The early reports of poxvirus vectors paved the way for and stimulated the development of other viral vectors and recombinant DNA vaccines. Published by Elsevier Ltd.
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