期刊
VACCINE
卷 31, 期 24, 页码 2698-2704出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2013.03.068
关键词
PRRSV GP5; PCV2 Cap; Mycoplasma hyopneumoniae P97; Adenovectors; Antibody response; Immunopotentiation
资金
- New initiatives grants from the Centre de Recherche en Infectiologie Porcine (CRIP)
- La Fondation UQAM
- CRIP
Porcine reproductive and respiratory syndrome virus (PRRSV), Porcine Circovirus type 2 (PCV2) and Mycoplasma (M.) hyopneumoniae are swine pathogens of economic importance. Although vaccines are available for each pathogen, no commercial bivalent vaccines have been developed so far. In this study, recombinant adenovectors (AdVs) expressing proteins of each pathogen were developed and their immunogenicity tested in mice. The proteins of interest were the glycoprotein GP5 of PRRSV, the capsid (Cap) protein of PCV2b and the C-terminal portion of P97 (P97c) protein of M. hyopneumoniae that were used alone and/or in fusion which each other. Inoculation of mice with the AdVs resulted in antibody (Ab) responses specific to the immunogens. Unexpectedly, immunization with vaccines expressing P97c in fusion to either Cap or GP5 enhanced the Ab responses against Cap and GP5, suggesting an immunopotentiator effect for P97c. (C) 2013 Elsevier Ltd. All rights reserved.
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