期刊
VACCINE
卷 29, 期 38, 页码 6679-6685出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.06.099
关键词
Helicobacter pylori; Vaccine; Therapeutic immunization; Attenuated Salmonella
资金
- Chinese National Natural Science Foundation [30771992]
- National High Technology Research and Development Program of China (863 Program) [2006AA02A208]
- Major National Science & Technology Specific Projects of China [2009ZX09102-220]
Therapeutic vaccination is a desirable alternative for controlling Helicobacter pylori (H. pylori) infection. In the present study, attenuated Salmonella vector vaccines were constructed that expressed fusion proteins complexed with H. pylori CagA, VacA and UreB in different arrangements, and their therapeutic efficacy was evaluated in H. pylori-infected mice. Oral therapeutic immunization with attenuated Salmonella, which expressed the fused protein CVU, significantly decreased H. pylori colonization in the stomach; protection was related to specific CD4(+) T cell Th1 type responses and serum IgG and mucosal sIgA antibody responses. These findings suggested that therapeutic efficacy was related to the arrangement of the fusion protein. It is possible that arrangement decides the expression of recombinant antigen in mice, and the latter results in different therapeutic efficacy. The attenuated Salmonella vector vaccine, which expressed the fused protein arrangement CVU, is superior to others, and could be a candidate vaccine against H. pylori. (C) 2011 Elsevier Ltd. All rights reserved.
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