Article
Immunology
Eleni Vatzia, Katherine Feest, Adam McNee, Tanuja Manjegowda, B. Veronica Carr, Basudev Paudyal, Tiphany Chrun, Emmanuel A. A. Maze, Amy Mccarron, Susan Morris, Helen E. E. Everett, Ronan MacLoughlin, Francisco J. J. Salguero, Teresa Lambe, Sarah C. C. Gilbert, Elma Tchilian
Summary: The study found that immunization with chimpanzee adenovirus and modified vaccinia Ankara vaccines expressing conserved influenza virus proteins can provide enhanced immune responses against H3N2 influenza and reduce viral shedding and lung pathology. The results are significant for the development of a broadly protective influenza vaccine and will contribute to future vaccine and clinical trial design.
Article
Immunology
Tor Kristian Andersen, Johanna Bodin, Fredrik Oftung, Bjarne Bogen, Siri Mjaaland, Gunnveig Grodeland
Summary: The 2009 swine flu pandemic exposed the limitations of egg-based vaccines in terms of global supply, prompting the urgent need for efficient new vaccine platforms; DNA vaccines have since been developed as a temperature stable, cost-effective option for pandemic responses, capable of inducing rapid protective immune responses without the need for adjuvants.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Review
Public, Environmental & Occupational Health
Alex Asamoah Ankomah, Aye Moa, Abrar Ahmad Chughtai
Summary: This study examines the development and rollout of the 2009 influenza A(H1N1) pandemic vaccine and identifies knowledge challenges for COVID-19 vaccination programs and future influenza pandemics. The findings reveal initial high demand, vaccine shortages, skewed distribution towards high-income countries, and low vaccination rates due to low-risk perception, safety concerns, and fear of adverse effects.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Immunology
Lesley R. de Armas, Varghese George, Abdelali Filali-Mouhim, Courtney Steel, Anita Parmigiani, Coleen K. Cunningham, Adriana Weinberg, Lydie Trautmann, Rafick-Pierre Sekaly, Mark J. Cameron, Savita Pahwa
Summary: Individuals living with HIV often show poor responses to influenza vaccination despite viral suppression through antiretroviral therapy. This study focused on identifying immune correlates of vaccine response in HIV-infected pediatric and adolescent individuals, with differences in gene expression patterns and pathways observed between high and low antibody responders. Age was also found to play a role in the immune responses, with older individuals exhibiting enriched gene pathways associated with T follicular helper cells following vaccination. These findings provide valuable insights for the development of improved vaccine strategies in HIV-infected children across different age groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Giulia Collatuzzo, Giovanni Visci, Francesco S. Violante, Stefano Porru, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Francesca Larese Fillon, Corrado Negro, Christian Janke, Noemi Castelletti, Giuseppe De Palma, Emanuele Sansone, Dana Mates, Silvia Teodorescu, Eleonora Fabianova, Jana Beresova, Luigi Vimercati, Silvio Tafuri, Mahsa Abedini, Giorgia Ditano, Shuffield S. Asafo, Paolo Boffetta
Summary: This study analyzed the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose COVID-19 vaccination in an international cohort of healthcare workers. The results showed that female sex, young age, past infection, two vaccine doses, and mRNA and heterologous vaccination predicted higher antibody levels. These findings provide valuable data for comparison with trends observed with longer follow-ups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Huy Quang Quach, Krista M. Goergen, Diane E. Grill, Iana H. Haralambieva, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy
Summary: This study identified shared gene expression pathways in response to influenza and vaccinia virus stimulation in different immune cells. The immune response signaling pathways identified can be targeted for the development of broad therapeutics and vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhaozhen Liu, Can Pang, Yuchuan Deng, Caiping Guo, Jia Li, Yanping Li, Ruolei Xin, Xiyao Li, Conghui Xu, Chun Huang, Hongyan Lu, Jie Li
Summary: This study investigated the immunogenicity of the quadrivalent inactivated influenza vaccine in HIV-infected and uninfected individuals, and found that HIV-infected individuals had weaker immune responses, especially those with CD4+ T cell counts below 350 cells/mm3.
Article
Virology
Helen E. Everett, Pauline M. van Diemen, Mario Aramouni, Andrew Ramsay, Vivien J. Coward, Vincent Pavot, Laetitia Canini, Barbara Holzer, Sophie Morgan, Mark E. J. Woolhouse, Elma Tchilian, Sharon M. Brookes, Ian H. Brown, Bryan Charleston, Sarah Gilbert
Summary: This study evaluated the efficacy of different vaccines in reducing nasal shedding in pigs following pH1N1 virus challenge and their transmission to naive, directly in-contact pigs. Vaccines containing homologous HA significantly reduced virus shedding, yet transmission still occurred to susceptible cohoused recipients. The findings are crucial for informing disease surveillance and control strategies and determining necessary vaccine coverage for disease moderation or herd protection.
JOURNAL OF VIROLOGY
(2021)
Review
Immunology
Steven Rockman, Beverly Taylor, John W. McCauley, Ian G. Barr, Ray Longstaff, Ranbir Bahra
Summary: The COVID-19 pandemic has led to rapid investigation and deployment of vaccine platforms never used before. Both new and existing vaccine platforms are likely to play a crucial role in combating future pandemics, especially influenza. The field of influenza vaccine manufacturing has a long history of successes and advancements in the past decade.
Review
Immunology
Irina Isakova-Sivak, Ekaterina Stepanova, Daria Mezhenskaya, Victoria Matyushenko, Polina Prokopenko, Ivan Sychev, Pei-Fong Wong, Larisa Rudenko
Summary: Current research has focused on improving antibody responses to conserved B cell epitopes and inducing T cells recognizing highly conserved viral epitopes for universal influenza vaccines. The development of T cell-based universal influenza vaccines is challenging due to factors such as the diversity of MHCs in the population and the lack of adequate animal models. Vaccines that elicit significant levels of T cells recognizing conserved epitopes possess high cross-protective potential against circulating influenza viruses.
EXPERT REVIEW OF VACCINES
(2021)
Article
Virology
Giulia Collatuzzo, Vittorio Lodi, Daniela Feola, Giuseppe De Palma, Emanuele Sansone, Emma Sala, Christian Janke, Noemi Castelletti, Stefano Porru, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Francesca Larese Filon, Corrado Negro, Luca Cegolon, Jana Beresova, Eleonora Fabianova, Lucia A. Carrasco-Ribelles, Pere Toran-Monserrat, Marta Maria Rodriguez-Suarez, Guillermo Fernandez-Tardon, Shuffield S. Asafo, Giorgia Ditano, Mahsa Abedini, Paolo Boffetta
Summary: This study analyzed the antibody levels after 9 months of COVID-19 vaccination and identified factors influencing these levels. The results showed that antibody levels were associated with gender, age, time since vaccination, previous infection, number of vaccine doses, and vaccine type. Additionally, the study observed a declining trend in antibody levels over time.
Review
Immunology
Yiwen Xie, Xuebin Tian, Xiaodi Zhang, Hangping Yao, Nanping Wu
Summary: Vaccines have been successful in controlling infectious diseases, but influenza and COVID-19 vaccines face challenges due to the variability of the viral proteins. Immune imprinting and repeated vaccinations can negatively influence vaccine effectiveness, and co-administration of multiple vaccines can also interfere with their effectiveness. Future development of COVID-19 vaccines should focus on inducing cross-reactive T-cell responses and naive B-cell responses, while the strategy of co-administering influenza and COVID-19 vaccines needs more careful consideration and further clinical data.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Mark B. Carascal, Rance Derrick N. Pavon, Windell L. Rivera
Summary: This review discusses the progress and advances in the development of recombinant influenza vaccines (RIVs) in the context of heterosubtypic immunity induction for universal vaccine production. Vaccination is considered the most effective strategy against the influenza virus, and RIVs have shown promising potential as universal vaccine candidates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Vincenzo Puro, Concetta Castilletti, Chiara Agrati, Delia Goletti, Sara Leone, Alessandro Agresta, Eleonora Cimini, Eleonora Tartaglia, Rita Casetti, Francesca Colavita, Silvia Meschi, Giulia Matusali, Daniele Lapa, Saeid Najafi Fard, Alessandra Aiello, Chiara Farrone, Paola Galli, Maria Rosaria Capobianchi, Giuseppe Ippolito
Summary: The study evaluated the impact of previous influenza and/or pneumococcal vaccination on the immune response to the SARS-CoV-2 BNT162b2 mRNA vaccine. Results showed that workers who received the influenza vaccine or concomitant influenza and pneumococcal vaccine may have increased neutralization titers, while female workers demonstrated better immune responses compared to male workers.
Article
Immunology
Cheng-Yin Tseng, Mao-Feng Sun, Tzu-Chien Kao, Tsai-Chung Li, Ching -Ting Lin
Summary: The study found that Coptis chinensis and its compounds have potential antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae (CRKP) and can enhance the effectiveness of colistin. They may represent a promising component of combination therapy in clinical settings for CRKP infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Psychiatry
Tsai-Chung Li, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Cheng-Chieh Lin
Summary: This study aimed to investigate the association between obesity marker trajectory patterns and cognitive impairment and decline in older adults. The results showed that maintaining high levels of fat mass and abdominal fat, as well as having a U-shaped trajectory of waist-to-hip ratio, were associated with a lower risk of cognitive impairment. Additionally, a low but slowly increasing trend in waist-to-hip ratio was associated with a decreased risk of cognitive decline.
Article
Medicine, General & Internal
Pei-Chun Lin, Cheng-Chieh Lin, Chia-Ing Li, Tang-Chuan Wang, Yi-Hao Peng, Tung-Ti Chang, Chin-Yi Lin, Tsai-Chung Li, Ching-Liang Hsieh
Summary: Patients with type 2 diabetes have a higher risk of COPD and asthma. Traditional Chinese medicine (TCM) may be beneficial for these patients. A retrospective cohort study found that TCM use was associated with a reduced risk of respiratory hospitalizations, especially in patients with diabetes for <3 years.
Article
Endocrinology & Metabolism
Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Li-Na Liao, Chuan-Wei Yang, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Summary: Through Mendelian randomization (MR) analysis, this study aimed to evaluate the causal relationship between high-sensitivity C-reactive protein (hsCRP) level and diabetic nephropathy (DN). The results showed that hsCRP level was causally related to DN, providing experimental evidence for understanding the mechanism and treatment of DN.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Biochemistry & Molecular Biology
Long-Bin Jeng, Tsai-Chung Li, Wen-Ling Chan, Chiao-Fang Teng
Summary: This study aimed to identify independent prognostic biomarkers from 75 HBV-related HCC patients and validate their potential as a combination biomarker for HCC recurrence with pre-S2 gene deletion mutation. The study found that patients with both pre-S2 gene deletion mutation and TNM stage IIIA-IIIC had a higher risk of HCC recurrence. Furthermore, the combination of pre-S2 gene deletion mutation and TNM stage had better performance in predicting HCC recurrence than either factor alone. In conclusion, the study proposed that TNM stage holds significance as a combination biomarker with pre-S2 gene deletion mutation for predicting HCC recurrence after curative surgical resection.
Review
Infectious Diseases
Fatima Ericka S. Vista, Ourlad Alzeus G. Tantengco, Micah D. Dispo, Danna Mae S. Opiso, Christian Luke D. C. Badua, John Patrick Z. Gerardo, Juan Raphael M. Perez, Karol Ann T. Baldo, Day-Yu Chao, Leslie Michelle M. Dalmacio
Summary: This review analyzes the trends in seroprevalence studies of flaviviruses using IgG ELISA. The results show that dengue virus is the most studied, while Japanese Encephalitis Virus is the least studied. Geographically, serosurveys align with known disease prevalence. Temporally, the number of serosurveys increases after outbreaks and epidemics, except for JEV which is studied to demonstrate vaccination effectiveness. Commercial kits are commonly used for DENV, WNV, and ZIKV. Overall, most studies use an indirect ELISA format and the choice of antigens varies per virus. Endemicity, cross-reactivities, and kit availabilities affect assay choice in serosurveys.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Virology
Ching-Hung Lin, BoJia Chen, Day-Yu Chao, Feng-Cheng Hsieh, Chun-Chun Yang, Hsuan-Wei Hsu, Hon-Man-Herman Tam, Hung-Yi Wu
Summary: This study investigates the characteristics of defective viral genomes (DVGs) in coronavirus, including their structures, reproducibility, origins, and adaptability to different infection environments. The findings contribute to the understanding of gene expression mechanisms and pathogenesis in coronavirus, and could potentially aid in the development of antiviral strategies.
Article
Integrative & Complementary Medicine
Yi-Chun Ma, Jaung-Geng Lin, Cheng-Chieh Lin, Chia-Ing Li, Hui-Man Cheng, Tsai -Chung Li
Summary: This study found that traditional Chinese medicine formulas were significantly associated with a decreased risk of infectious hospitalization among patients with SLE. TCM formulas can be used as a part of SLE treatments to decrease the risk of infectious hospitalization.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin
Summary: This study investigated the relationship between body shape index (ABSI) and mortality rate in patients with type 2 diabetes. The results showed that ABSI was closely associated with mortality rate, along with other indices such as BMI, WC, WHR, WHtR, and BRI. The combined use of ABSI and BMI provided better explanation of the variation in death risk compared to the independent use of BMI or other indices.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Meeting Abstract
Biophysics
Jan K. Marzinek, Venkata Raghuvamsi Palur, Gielenny Salem, Fan-Chi Chen, Shang-Rung Wu, Peter J. Bond, Day-Yu Chao
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Venkata Raghuvamsi Palur, Gielenny Salem, Fan-Chi Chen, Shang-Rung Wu, Peter J. Bond, Day-Yu Chao, Jan K. Marzinek
BIOPHYSICAL JOURNAL
(2023)
Article
Immunology
Hong -Dar Isaac Wu, Ruey-Shing Lin, Wen -Han Hwang, Mei-Liang Huang, Bo-Jia Chen, Tseng-Chang Yen, Day -Yu Chao
Summary: The ongoing circulation and reassortment of low-pathogenic avian influenza viruses have caused economic losses and public health concerns. Virologic surveillance of wild birds is recommended as part of a global monitoring system. However, underreporting and biased sampling have hindered understanding of highly pathogenic avian influenza transmission. In this study, we used the eBird database to examine the distribution of wild birds in Taiwan and their potential for virus exchange with domestic poultry. Our findings provide a methodological blueprint for incorporating this into the global surveillance system.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Li-Na Liao, Tsai-Chung Li, Chih-Ching Yeh, Chia-Ing Li, Chiu-Shong Liu, Chuan-Wei Yang, Ya-Fei Yang, Chih-Hsueh Lin, Fuu-Jen Tsai, Cheng-Chieh Lin
Summary: This study developed and validated a risk prediction model for diabetic nephropathy (DN) in the Han Chinese population by integrating clinical factors and genetic SNPs from multiple CKD-related pathways. This model can be used as a screening tool for early intervention and prevention in clinical risk management practice.
ACTA DIABETOLOGICA
(2023)
Article
Medicine, General & Internal
Cheng-Hung Lee, Chia- Tsai, Yi-Chang Su, Shih-Yi Lin, I-Te Lee, Tsai-Chung Li
Summary: This study found that body constitution independently predicts new-onset albuminuria in individuals with type 2 diabetes. Yin deficiency and phlegm stasis are associated with an increased risk of albuminuria, and this relationship is influenced by glucose control status.
Article
Health Care Sciences & Services
Yu-Shan Chang, Yi-Chuan Cheng, Tsai-Chung Li, Li-Chi Huang
Summary: This study explored the perceived level of stress in mothers one month after hospital discharge following the birth of singleton and multiple preterm infants. The findings suggest that social support and sleep deprivation are predictive indicators of maternal stress in preterm infants. It is recommended that the differences in stress and needs of mothers with singleton and multiple births be recognized and addressed in clinics.
