Article
Immunology
Jacqueline E. Tate, Jason M. Mwenda, Adama Mamby Keita, Toussaint Wendlamita Tapsoba, Edouard Ngendahayo, Bertin Dibi Kouame, Ahmadou Lamin Samateh, Negar Aliabadi, Seydou Sissoko, Yacouba Traore, Justin Bayisenga, Moufidath Sounkere-Soro, Sheriffo Jagne, Rachel M. Burke, Uma Onwuchekwa, Ma Ouattara, Joel B. Bikoroti, Kofi N'Zue, Eyal Leshem, Oumar Coulibaly, Issa Ouedraogo, Jeannine Uwimana, Samba Sow, Umesh D. Parashar
Summary: In a pooled analysis from 5 African countries, RotaTeq vaccination was not associated with an increased risk of intussusception, highlighting the importance of vaccine-specific and setting-specific risk monitoring.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Meru Sheel, Nicholas Wood, Kristine Macartney, Jim Buttery, Nicole Dinsmore, Helen Marshall, Elizabeth Elliott, Anne Kynaston, Peter Richmond, Dan Chateau, Peter McIntyre
Summary: Studies have found that cases of intussusception within 21 days of receiving rotavirus vaccine are more severe and occur at a younger age. However, after adjusting for age and sex, the severity of intussusception is not related to the vaccine.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Infectious Diseases
Anna Roose, Adama Mamby Keita, Milagritos D. Tapia, Samba O. Sow, T. Christopher Mast, Karen L. Kotloff
Summary: This study estimated the incidence of intussusception among infants in Bamako, Mali before and after the introduction of pentavalent rotavirus vaccine using chart review and prospective surveillance data. The results showed no significant difference in the incidence post-introduction compared to pre-introduction.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Review
Public, Environmental & Occupational Health
Tina Singh, Frederique Delannois, Francois Haguinet, Lifeter Yenwo Molo
Summary: Rotavirus is the most common cause of acute gastroenteritis in children worldwide, and vaccination reduces the disease burden. However, studies have shown an increased risk of intussusception in infants post-vaccination. Current research indicates a positive benefit-risk balance for rotavirus vaccines and a long-term reduction in intussusception.
Article
Immunology
Julia R. Diller, Maximilian H. Carter, Yuta Kanai, Shania Sanchez, Takeshi Kobayashi, Kristen M. Ogden
Summary: Analysis of infant sera samples under different vaccination conditions revealed that vaccination with the multivalent RotaTeq vaccine can induce a broader neutralizing antibody response, and the addition of a dose of RotaTeq can also enhance the neutralizing response to the G type. In addition, there were differences in infectivity, replication, and neutralization of some monoreassortant viruses in different cell types.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Floriana Bonura, Leonardo Mangiaracina, Chiara Filizzolo, Celestino Bonura, Vito Martella, Max Ciarlet, Giovanni M. Giammanco, Simona De Grazia
Summary: This study compared the seasonal distribution and molecular characteristics of RV strains detected in Sicily over a 19-year period to understand the impact of the Rotarix (R) vaccine on the evolution of human RVs. The results showed a decrease in RV prevalence and loss of seasonality since the introduction of the vaccine. The distribution of RV genotypes also changed over time, possibly due to the vaccine introduction and the replacement of G1P[8] strains with other emerging strains.
Article
Pediatrics
Poonam Dalal, Geeta Gathwala, Jasbir Singh, Nayana P. Nair, Varunkumar Thiyagarajan
Summary: This study evaluated the epidemiology of rotavirus gastroenteritis in Haryana post-introduction of rotavirus vaccine, showing a decline in rotavirus positivity from 22.8% in 2016 to 14.5% in 2019 among children under 5 years of age.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Natasha Makabilo Laban, Samuel Bosomprah, Michelo Simuyandi, Mwelwa Chibuye, Adriace Chauwa, Masuzyo Chirwa-Chobe, Nsofwa Sukwa, Chikumbutso Chipeta, Rachel Velu, Katanekwa Njekwa, Cynthia Mubanga, Innocent Mwape, Martin Rhys Goodier, Roma Chilengi
Summary: This study assessed the safety and immune boosting effect of a third dose of oral ROTARIX((R)) vaccine administered at 9 months of age, and found that it can be safely administered and enhance immunity, providing opportunities for improving rotavirus vaccine immunity within national immunization programs.
Article
Immunology
Zhike Liu, Ning Li, Guangxu Liu, Lu Xu, Ying Dong, Ruogu Meng, Yu Yang, Siyan Zhan
Summary: This study assessed the incidence and risk of intussusception within 90 days after vaccination with RotaTeq in Chinese infants. The study concluded that there was no increased risk of intussusception following 3 months of RotaTeq vaccination.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Immunology
Casey Hensley, Charlotte Nyblade, Peng Zhou, Viviana Parreno, Ashwin Ramesh, Annie Frazier, Maggie Frazier, Sarah Garrison, Ariana Fantasia-Davis, Ruiqing Cai, Peng-Wei Huang, Ming Xia, Ming Tan, Lijuan Yuan
Summary: Human rotavirus (HRV) is a significant cause of diarrhea in children under the age of five, particularly in low- and middle-income countries. This study evaluated the immunogenicity and protective efficacy of a nanoparticle-based HRV vaccine in pig models. Although the vaccine regimens did not provide significant protection against diarrhea, the prime-boost strategy showed promise in reducing the duration and severity of virus shedding.
Article
Virology
Sebotsana Rasebotsa, Jeannine Uwimana, Milton T. Mogotsi, Kebareng Rakau, Nonkululeko B. Magagula, Mapaseka L. Seheri, Jason M. Mwenda, M. Jeffrey Mphahlele, Saheed Sabiu, Richard Mihigo, Leon Mutesa, Martin M. Nyaga
Summary: Children in low- and middle-income countries, such as Rwanda, are more susceptible to rotavirus compared to developed countries. The evolutionary mechanisms of multiple reassortant rotavirus strains have been documented, influencing the diversity and dynamics of novel rotaviruses. Whole-genome analysis of rotavirus strains in Rwanda identified genetic reassortment and highlighted similarities and differences with vaccine strains, emphasizing the importance of ongoing genomic analysis in understanding rotavirus evolution and vaccination effectiveness.
Article
Pediatrics
Yuya Fukuda, Yusuke Akane, Saho Honjo, Yukihiko Kawasaki, Hiroyuki Tsutsumi, Takeshi Tsugawa
Summary: The aim of this study was to analyze the epidemiology of intussusception in Hokkaido Prefecture, Japan over a 10-year period coinciding with the introduction of the rotavirus vaccine. A retrospective surveillance was conducted in 17 hospitals, comparing data before and after the vaccine introduction. The results showed a significant reduction in intussusception incidence among children under 1 year old after the vaccine was introduced. Further research is needed to determine the impact of routine rotavirus vaccination since 2020.
Article
Biotechnology & Applied Microbiology
Kei Kozawa, Yuki Higashimoto, Yoshiki Kawamura, Hiroki Miura, Takumi Negishi, Fumihiko Hattori, Masaru Ihira, Satoshi Komoto, Koki Taniguchi, Tetsushi Yoshikawa
Summary: This study investigated the molecular epidemiology of rotavirus (RV) among different groups of RV gastroenteritis (RVGE) patients in Japan who received different RV vaccines. The clinical features of the RVGE patients were compared among the groups. Results showed that the severity of illness was significantly lower in vaccinated patients compared to those who were not vaccinated.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Microbiology
Ran Zhuo, Gillian A. M. Tarr, Jianling Xie, Stephen B. Freedman, Daniel C. Payne, Bonita E. Lee, Charlotte McWilliams, Linda Chui, Samina Ali, Xiaoli Pang
Summary: A new assay was developed to detect the presence of RV1-derived rotavirus strains, with results showing that these strains are not significantly associated with the development of gastroenteritis symptoms.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Virology
Slavica Mijatovic-Rustempasic, Jose Jaimes, Charity Perkins, M. Leanne Ward, Mathew D. Esona, Rashi Gautam, Jamie Lewis, Michele Sturgeon, Junaid Panjwani, Gail A. Bloom, Steve Miller, Erik Reisdorf, Ann Marie Riley, Morgan A. Pence, James Dunn, Rangaraj Selvarangan, Robert C. Jerris, Dona DeGroat, Umesh D. Parashar, Margaret M. Cortese, Michael D. Bowen
Summary: This study reported the genotype distribution of group A rotaviruses (RVA) collected over a span of 20 years and found changes in genotype dominance. Vaccine strains and uncommon/unusual strains were also detected. Continuous surveillance is needed to understand the long-term effects of vaccine use on RVA epidemiology and evolutionary dynamics.
Article
Health Care Sciences & Services
Eman M. A. Alenezi, Kathryn Jajko, Allison Reid, Alessandra Locatelli-Smith, Courtney S. E. McMahen, Karina F. M. Tao, Julie Marsh, Tess Bright, Peter C. Richmond, Robert H. Eikelboom, Christopher G. Brennan-Jones
Summary: This study found that video otoscopy recordings provide clearer views of the tympanic membrane and increase the ability to make diagnoses, compared to still images. Research assistants with limited practice were able to obtain video otoscopy images and recordings that were comparable to the ones obtained by clinicians.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Allergy
Katherine Y. H. Chen, Wanyu Chu, Renee Jones, Peter Vuillermin, David Fuller, David Tran, Lena Sanci, Shivanthan Shanthikumar, John Carlin, Harriet Hiscock
Summary: This study examined the rates of hospital readmission and emergency department re-presentation for asthma in Australian children. It also explored the effects of modifiable factors on hospital readmission, including the role of general practitioners and home environmental factors. The findings suggest that hospital readmissions for asthma are increasing among Australian children, and highlight the important role of general practitioners in managing pediatric asthma. There was no apparent association between hospital or home environmental factors and hospital readmissions.
Article
Immunology
Shraddha Uttekar, Noni MacDonald, Walter A. Orenstein, Margie Danchin, Vince Blaser, Angus Thomson, Lisa Menning, Lora Shimp, Barbara Rath, Rupali Limaye, Dorothy Esangbedo, Surangani Abeyesekera, Siff Malue Nielsen, Susan Mackay, Tina Purnat, Karthickeyan Duraisamy, Vanithapriyaa Karthickeyan, Aninda Siddique, Naveen Thacker
Summary: The International Pediatric Association (IPA) developed an online course called "Vaccine Trust Course" to improve the quality of interactions between health workers (HWs) and vaccine recipients. The course helped HWs increase their empathy, counseling confidence, and patient vaccine acceptance.
Review
Immunology
Bianca F. Middleton, Margie Danchin, Parveen Fathima, Julie E. Bines, Kristine Macartney, Thomas L. Snelling
Summary: The review evaluates the health impact of the oral rotavirus vaccine program in Australia over the first 15 years. The introduction of the program has led to a significant reduction in rotavirus-related hospitalizations. However, there is a need to improve vaccine impact for Aboriginal and Torres Strait Islander populations.
Article
Immunology
Federico Martinon-Torres, Jacek Wysocki, Leszek Szenborn, Alfonso Carmona-Martinez, Airi Poder, Ron Dagan, Peter Richmond, Christopher Gilbert, Marie-Chantale Trudel, Sheryl Flores, Robert Lupinacci, Richard McFetridge, Richard T. Wiedmann, Qiuxu Chen, Han Gerrits, Natalie Banniettis, Luwy Musey, Kara Bickham, Janusz Kaminski
Summary: This study evaluated the safety and immunogenicity of V114 and PCV13 in healthy infants. The results showed that V114 elicited immune responses to 13 shared serotypes comparable to PCV13, and had superior responses to two additional serotypes. These findings support the routine use of V114 in infants.
Article
Biochemical Research Methods
Yue C. Wu, Steven Mascaro, Mejbah Bhuiyan, Parveen A. Fathima, Ariel Mace, Mark L. Nicol, Peter Richmond, Lea-Ann Kirkham, Michael A. Dymock, David L. Foley, Charlie C. McLeod, Meredith E. Borland, Andrew V. Martin, Phoebe C. M. E. Williams, Julie V. Marsh, Thomas E. Snelling, Christopher E. Blyth
Summary: This study developed a causal Bayesian network model to predict the causative pathogen for pediatric pneumonia. The model demonstrated reliable diagnostic performance and aid in antibiotic treatment decisions. This research provides a novel approach to addressing the challenges in diagnosing and treating pneumonia.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Immunology
Huong Le, Heather Gidding, Christopher C. Blyth, Peter Richmond, Hannah C. Moore
Summary: Through population-based linked data analysis, we have demonstrated the real-world protective effect of pneumococcal conjugate vaccines on respiratory syncytial virus hospitalizations in infants. These findings are particularly relevant for areas with a high burden of respiratory syncytial virus but no widespread pneumococcal conjugate vaccine program.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Mohinder Sarna, Amanuel Gebremedhin, Peter Richmond, Avram Levy, Kathryn Glass, Hannah C. Moore
Summary: Respiratory syncytial virus is a major cause of illness and death in infants worldwide. By analyzing pre-pandemic RSV testing data and hospital admission data, a statistical prediction model was used to estimate RSV-hospitalizations in infants under 1 year old. The highest incidence rate of RSV-hospitalization in infants under 6 months was found in those born in April/May.
Article
Immunology
Mohinder Sarna, Amanuel Gebremedhin, Peter C. Richmond, Kathryn Glass, Avram Levy, Hannah C. Moore
Summary: This study examined the association between sociodemographic and perinatal factors and childhood respiratory morbidity following early-life respiratory syncytial virus (RSV) infection. The results showed that in addition to preterm and young infants, children aged 12-<24 months could also be potential target groups for RSV prevention.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Zephaniah Hilton, Monsurul Hoq, Margie Danchin, Jessica Kaufman
Summary: COVID-19 vaccine uptake among 5-11-year-olds is lower than that of the 12+ age group. A decision support tool was assessed for its impact on parents' decisional conflict, vaccine hesitancy, and intention to vaccinate. The tool was found to be moderately effective at reducing decisional conflict, particularly among undecided parents.
Article
Health Care Sciences & Services
Natasha K. Brusco, Margie Danchin, Jennifer J. Watts, Carol Jos, Myles Loughnan, Tria Williams, Julie Ratcliffe, Monsurul Hoq, Shidan Tosif, Jessica Kaufman
Summary: During the height of the COVID-19 pandemic in Australia, there was a decrease in the quality of life for both adults and children. However, the study found that there was no significant difference in quality of life between on-site schooling and home schooling during this period.
Article
Immunology
Christopher C. Blyth, Parveen Fathima, Rebecca Pavlos, Peter Jacoby, Olivia Pavy, Elizabeth Geelhoed, Peter C. Richmond, Paul Effler, Hannah C. Moore
Summary: The study found that increasing childhood influenza vaccine coverage can significantly reduce influenza cases and healthcare costs. For children under 5 years old, every 10% increase in vaccine coverage saves over AU$1.5 million in costs. Including primary-school aged children in the vaccination program results in additional benefits, with every 10% increase in coverage reducing cases, presentations, hospitalisations, and saving approximately AU$4 million in net costs.
Article
Infectious Diseases
David E. Bloom, Paolo Bonanni, Federico Martinon-Torres, Peter C. Richmond, Marco A. P. Safadi, David M. Salisbury, Apostolos Charos, Katharina Schley, Jamie Findlow, Paul Balmer
Summary: The global landscape of invasive meningococcal disease (IMD) has changed during the COVID-19 pandemic, with decreased incidence rates due to mitigation measures. However, some countries have experienced an increase in IMD cases and rates that may exceed pre-pandemic levels. Other concerns include vaccination coverage gaps, increased incidence of other respiratory pathogens, immunity debt, and increased variability in IMD epidemiology.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Psychology, Multidisciplinary
Ellaina Andersson, Cari Mcilduff, Karen M. T. Turner, Emily Carter, Marmingee Hand, Sue Thomas, Jadnah Davies, Stewart Einfeld, Elizabeth J. Elliott
Summary: This study demonstrates the feasibility of delivering Indigenous Triple P to Aboriginal families in remote settings, emphasizing the importance of community partnership. Program tailoring, flexible delivery, use of Aboriginal parent coaches, and provision of practical support resulted in a culturally acceptable parent support program.
AUSTRALIAN PSYCHOLOGIST
(2023)
Article
Otorhinolaryngology
Eman M. A. Alenezi, Monique Robinson, Elizabeth J. Mckinnon, Samuel D. Calder, Tamara Veselinovic, Peter C. Richmond, Robert H. Eikelboom, Christopher G. Brennan-Jones
Summary: This longitudinal cohort study aims to investigate the impact of early childhood ventilation tube insertion (VTI) on long-term language outcomes. The results show that children who received VTI in early childhood had lower scores in language outcomes during school age, suggesting a potential long-term risk.
CLINICAL OTOLARYNGOLOGY
(2023)