期刊
VACCINE
卷 29, 期 40, 页码 6994-7001出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.07.035
关键词
Streptococcus pneumoniae; Pneumococcal conjugate vaccine; HIV; Immunogenicity; Colonization; Hypo-responsiveness
资金
- National Institute of Allergy and Infectious Diseases (NIAID) of the US National Institutes for Health (NIH), through the Comprehensive International Program of Research on AIDS (CIPRA) network [U19 AI53217]
- National Institute of Allergies & Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200800014C]
- Gates Grand Challenge PneumoCarr Project
- GSK
- Pfizer
- Wyeth
Background: Heightened immunogenicity, measured one month after the primary series of pneumococcal conjugate vaccine (PCV), in African children was previously hypothesized to be due to increased rates of nasopharyngeal pneumococcal colonization during early infancy. Methods: We analyzed the effect of selected vaccine-serotype (68, 19F and 23F) nasopharyngeal colonization prior to the first PCV dose or when colonized for the first time prior to the second or third (2nd/3rd) PCV dose on serotype quantitative and qualitative antibody responses. Results: Colonization prior to receiving the first PCV was associated with lower geometric mean antibody concentrations (GMCs) one month after the third dose of PCV and six months later to the colonizing-serotype. Colonized infants also had lower geometric mean titers (GMTs) on opsonophagocytosis activity assay (OPA) and a lower proportion had titers >= 8 against the colonizing serotypes (19F and 23F) post vaccination. Colonization occurring only prior to the 2nd/3rdPCV dose was also associated with lower GMCs and OPA GMTs to the colonizing-serotype. The effect of colonization with serotypes 19F and 23F prior to PCV vaccination had a greater effect on a lower proportion of colonized infants having OPA titers >= 8 than the effect of colonization on the lower proportion with antibody >= 0.35 mu g/ml. Conclusion: Infant nasopharyngeal colonization at any stage before completing the primary series of PCV vaccination was associated with inferior quantitative and qualitative antibody responses to the colonizing-serotype. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据