期刊
VACCINE
卷 29, 期 3, 页码 476-486出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.10.072
关键词
Live attenuated Listeria monocytogenes; Live oral vaccine; HIV/AIDS vaccine; Cellular immune responses; Anti-vector immunity
资金
- NIH [P01 A1054558]
Listeria monocytogenes (Lm) is known to induce strong cellular immune responses. We constructed a live-attenuated Lm vector, Lmdd-BdopSIVgag, which encodes SIVmac239 gag. Intragastric (i.g.) administration of 3 x 10(12) bacteria to rhesus macaques was safe and induced anti-Gag cellular but no humoral immune responses. Boosting of Gag-specific cellular responses was observed after i.g. administration of Lmdd-BdopSIVgag to previously vaccinated RM despite preexisting anti-Lm immunity shown by lymphoproliferative responses. Surprisingly, anti-Lm cellular responses were also detected in non-vaccinated controls, which may reflect the fact that Lm is a ubiquitous bacterium. The novel, live-attenuated Lmdd-BdopSIVgag may be an attractive platform for oral vaccine delivery. (C) 2010 Elsevier Ltd. All rights reserved.
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