期刊
VACCINE
卷 28, 期 31, 页码 5075-5085出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.05.004
关键词
Allergy; Antigen presentation; Vaccination
资金
- Vinnova (Multidisciplinary Bio)
- Lund University
- Alfred Osterlund Foundation
- Japan Science and Technology Agency
Novel adjuvants and antigen-delivery systems with immunomodulatory properties that shift the allergenic Th2 response towards a Th1 or regulatory T cell response are desired for allergen-specific immunotherapy. This study demonstrates that 200-nm sized biodegradable poly(gamma-glutamic acid) (gamma-PGA) nanoparticles (NPs) are activators of human monocyte-derived dendritic cells (MoDCs). gamma-PGA NPs are efficiently internalized by immature MoDCs and strongly stimulate production of chemokines and inflammatory cytokines as well as up-regulation of co-stimulatory molecules and immunomodulatory mediators involved in efficient T cell priming. Furthermore, MoDCs from allergic subjects stimulated in vitro with a mixture of gamma-PGA NPs and extract of grass pollen allergen Phleum pratense (Phi p) augment allergen-specific IL-10 production and proliferation of autologous CD4(+) memory T cells. Thus, gamma-PGA NPs are promising as sophisticated adjuvants and allergen-delivery systems in allergen-specific immunotherapy. (C) 2010 Elsevier Ltd. All rights reserved.
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