Review
Immunology
Hui Cao, Li Guan, Xiaoyu Liu, Xiaojun Xiao
Summary: This paper reviews the research progress of probiotics in the prevention and alleviation of allergies, with a focus on their use as adjuvants for allergen-specific immunotherapy (AIT). The possibility of probiotics' extracellular proteins, extracellular vesicles, metabolites, and Toll-like Receptors (TLR) agonist analog as independent AIT adjuvants is also highlighted.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Masaki Morishita, Maho Horita, Ayaka Higuchi, Maho Marui, Hidemasa Katsumi, Akira Yamamoto
Summary: Research on probiotic-derived extracellular vesicles (EVs) reveals their potential therapeutic applications, with similar particle sizes and zeta potentials among EVs secreted by different probiotics, and their ability to activate the host's immune response. Furthermore, these EVs are mainly taken up by immune cells through clathrin-mediated endocytosis and macropinocytosis, stimulating the immune system to produce inflammatory cytokines, indicating their potential as a novel adjuvant formulation.
MOLECULAR PHARMACEUTICS
(2021)
Article
Medicine, General & Internal
Sapna P. Patel, Megan Othus, Yuanbin Chen, G. Paul Wright, Kathleen J. Yost, John R. Hyngstrom, Siwen Hu-Lieskovan, Christopher D. Lao, Leslie A. Fecher, Thach-Giao Truong, Jennifer L. Eisenstein, Sunandana Chandra, Jeffrey A. Sosman, Kari L. Kendra, Richard C. Wu, Craig E. Devoe, Gary B. Deutsch, Aparna Hegde, Maya Khalil, Ankit Mangla, Amy M. Reese, Merrick I. Ross, Andrew S. Poklepovic, Giao Q. Phan, Adedayo A. Onitilo, Demet G. Yasar, Benjamin C. Powers, Gary C. Doolittle, Gino K. In, Niels Kokot, Geoffrey T. Gibney, Michael B. Atkins, Montaser Shaheen, James A. Warneke, Alexandra Ikeguchi, Jose E. Najera, Bartosz Chmielowski, Joseph G. Crompton, Justin D. Floyd, Eddy Hsueh, Kim A. Margolin, Warren A. Chow, Kenneth F. Grossmann, Eliana Dietrich, Victor G. Prieto, Michael C. Lowe, Elizabeth I. Buchbinder, John M. Kirkwood, Larissa Korde, James Moon, Elad Sharon, Vernon K. Sondak, Antoni Ribas
Summary: This study aimed to investigate whether giving pembrolizumab both before and after surgery would improve event-free survival in patients with resectable stage III or IV melanoma. Results showed that patients who received pembrolizumab both before and after surgery had significantly longer event-free survival. Overall rating: 9 out of 10.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Nanki Hura, Sophia Song, Rebecca J. Kamil, Gerdline Pierre, Sandra Y. Lin
Summary: Sublingual immunotherapy (SLIT) is an effective alternative to subcutaneous immunotherapy (SCIT) with a better safety profile, but patient completion still relies on factors such as clinic visits and dosage adjustment. Patients younger than 12 with asthma are more likely to complete therapy. Increasing clinic visits and addressing concerns about therapy efficacy may improve patient completion rates.
Article
Gastroenterology & Hepatology
Winnie Fong, Qing Li, Fenfen Ji, Wei Liang, Harry Cheuk Hay Lau, Xing Kang, Weixin Liu, Kenneth Kin-Wah To, Zhong Zuo, Xiaoxing Li, Xiang Zhang, Joseph J. Y. Sung, Jun Yu
Summary: Lactobacillus gallinarum improves the efficacy of anti-PD1 in colorectal cancer by suppressing CD4+ Treg differentiation and enhancing CD8+ T cell function through modulating the IDO1/Kyn/AHR axis.
Article
Immunology
Shaobing Xie, Sijie Jiang, Hua Zhang, Fengjun Wang, Yongzhen Liu, Yongchuan She, Qiancheng Jing, Kelei Gao, Ruohao Fan, Shumin Xie, Zhihai Xie, Weihong Jiang
Summary: This study identified several serum biomarkers through metabolomics analysis that can reliably predict the efficacy of ASIT in AR patients, with these biomarkers mainly involving glycolysis, fatty acid metabolism, and other metabolic pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Baharudin Abdullah, Ruby Pawankar, Amir Hamzah Abdul Latiff, Kent Chee Keen Woo, Eike Wuestenberg, Mohamad Azizul Fitri Khalid, Yeoh Zhi Xiang, Salina Husain, Nurashikin Mohammad, Norasnieda Md Shukri
Summary: Allergic rhinitis is an inflammatory disease of the upper airway, impacting patients' quality of life and increasing the risk for asthma. Allergen-specific immunotherapy is a treatment that induces tolerance to allergens and has been proven to induce disease-modifying effects. It is recommended as a first-line treatment for moderate to severe allergic rhinitis, and guidelines are important for its appropriate indication and application.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Mahvash Sadeghi, Sanaz Keshavarz Shahbaz, Sajad Dehnavi, Khadijeh Koushki, Mojtaba Sankian
Summary: For allergen-specific sublingual immunotherapy (SLIT), utilizing appropriate allergen-presentation platforms can improve allergen efficacy, target immune cells, induce regulatory immune responses, enhancing treatment outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Microbiology
Aiko Oka, Mitsuhiro Okano
Summary: Research suggests that factors such as saliva pH, chemical properties, and microbiome composition may influence the efficacy of sublingual immunotherapy (SLIT), with certain antibodies increasing post-SLIT potentially contributing to treatment effectiveness. The advancement of metagenomic sequencing technology allows for the identification of microbiome composition and exploration of relationships between specific bacteria and immune responses. Such bacteria may have the potential to be utilized as biomarkers for patient selection and as adjuvants in SLIT.
Review
Microbiology
Daiju Sakurai, Hiroki Ishii, Ayumi Shimamura, Daisuke Watanabe, Takaaki Yonaga, Tomokazu Matsuoka
Summary: The incidence of Japanese cedar pollinosis is increasing significantly in Japan. Allergen immunotherapy is the only fundamental treatment that modifies the natural course of allergic rhinitis and provides long-term remission. Sublingual immunotherapy has been developed and proven to have long-term efficacy and safety.
Article
Dermatology
Chaodi Huang, Jianping Tang
Summary: Sublingual immunotherapy with Dermatophagoides farinae drops is safe and effective for pediatric atopic dermatitis. Prolonged treatment duration leads to improved efficacy, with maintained effectiveness even after treatment cessation.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hitoshi Maeda, Shota Ichimizu, Hiroshi Watanabe, Keisuke Hamasaki, Mayuko Chikamatsu, Ryota Murata, Nao Yumoto, Takahiro Seki, Hiroshi Katsuki, Masaki Otagiri, Toru Maruyama
Summary: Innovations in oral immunotherapy have improved the treatment of allergies by delivering larger amounts of antigens to antigen-presenting cells. A recent study found that a modified albumin can enter cells through macropinocytosis, leading to increased therapeutic effects. This novel system holds promise for enhancing the effectiveness of sublingual immunotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Prachi Bhave, Angela Hong, Serigne N. Lo, Rebecca Johnson, Johanna Mangana, Douglas B. Johnson, Ozgecan Dulgar, Zeynep Eroglu, Hui-Ling Yeoh, Andrew Haydon, Georg C. Lodde, Elisabeth Livingstone, Adnan Khattak, Katharina Kaehler, Axel Hausschild, Grant A. McArthur, Alexander Maxwell Menzies, Georgina Long, Wei Wang, Matteo S. Carlino
Summary: This study investigates the role of adjuvant radiation therapy (RT) in patients with melanoma who experience locoregional disease recurrence during or after adjuvant anti-PD-1-based immunotherapy. The results show that adjuvant RT is associated with improved locoregional disease control, but does not affect the risk of distant recurrence.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Nutrition & Dietetics
Zhongyue Ren, Yan Hong, Yalan Huo, Lingling Peng, Huihui Lv, Jiahui Chen, Zhihua Wu, Cuixiang Wan
Summary: In modern society, drugs remain the most important means of resistance against new diseases and viruses. However, adverse effects and diminished efficacy are leading causes of treatment failure and impaired quality of life for patients. Clinical studies have shown that disturbances in gut microbial structure play a crucial role in drug toxicity and side effects. Probiotics, known for their ability to maintain intestinal microecology balance, have potential as adjuncts to prevent and alleviate adverse drug reactions and enhance drug efficacy.
Review
Chemistry, Multidisciplinary
Alejandro Olivares-Hernandez, Luis Figuero-Perez, Rogelio Gonzalez-Sarmiento, David Leon-Jimenez, Juan Jesus Cruz-Hernandez, Jose Pablo Miramontes-Gonzalez
Summary: Different diets and probiotics have significant effects on the response to immune checkpoint inhibitors and survival rates associated with solid tumors. Probiotics influence resistance to immunotherapy by altering the gut microbiota. Lower intake of red meat, Mediterranean, or vegetarian diets may alter the mechanisms of resistance to ICIs.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
Robertus van Aalst, Ellyn M. Russo, Nabin Neupane, Salaheddin M. Mahmud, Jan Wilschut, Sandrine Samson, Ayman Chit, Maarten Postma, Yinong Young-Xu
Summary: In a study conducted in the US VHA population, high-dose influenza vaccination was found to significantly reduce hospitalization risks for cardiovascular and respiratory diseases. Reduction in hospitalizations for cardiovascular diseases contributed more to cost savings per high-dose recipient compared to respiratory diseases.
Letter
Infectious Diseases
J. Kevin Yin, Sandrine I. Samson, Joshua Nealon
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Health Care Sciences & Services
J. L. Lee, L. Foschini, S. Kumar, J. Juusola, J. Liska, M. Mercer, C. Tai, R. Buzzetti, M. Clement, X. Cos, L. Ji, N. Kanumilli, D. Kerr, E. Montanya, D. Mueller-Wieland, C. G. Ostenson, N. Skolnik, V. Woo, N. Burlet, M. Greenberg, S. I. Samson
Summary: In a 6-month intervention using an online health platform, the vaccination rate for influenza in people with self-reported diabetes was increased by 3.1% compared to the control group. Completion of intervention messages was associated with up to an 8% increase in vaccination rate. Leveraging new technology was effective in improving vaccination rates in high-risk populations such as PWD.
NPJ DIGITAL MEDICINE
(2021)
Article
Critical Care Medicine
Ruvim Izikson, Daniel Brune, Jean-Sebastien Bolduc, Pierre Bourron, Marion Fournier, Tamala Mallett Moore, Aseem Pandey, Lucia Perez, Nessryne Sater, Anju Shrestha, Sophie Wague, Sandrine Samson
Summary: This study assessed the safety and immunogenicity of concomitant administration of high-dose quadrivalent influenza vaccine (QIV-HD) and mRNA-1273 vaccine booster in older adults. The results showed no safety concerns or immune interference in the coadministration group, supporting the recommendations for co-administration. The antibody responses to influenza and SARS-CoV-2 were similar between the coadministration and QIV-HD groups.
LANCET RESPIRATORY MEDICINE
(2022)
Letter
Biotechnology & Applied Microbiology
J. Kevin Yin, Stephanie Pepin, Robertus van Aalst, Matthew M. Loiacono, Sandrine I. Samson
Summary: The article challenges the recommendation of high-dose influenza vaccine and criticizes the authors of inaccurate numbers-needed-to-vaccinate (NNV) calculation. It emphasizes the importance of preferential recommendation for vaccines preventing influenza/complications and considering the impact of vaccination within the context of disease burden. To address the threat of the COVID-19 pandemic, the article suggests implementing concomitant influenza/COVID-19 vaccination to reduce the burden of co-circulation of influenza and SARS-CoV-2 viruses and increase vaccine coverage as per the WHO mandate.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Health Care Sciences & Services
Nell J. Marshall, Jennifer L. Lee, Jessica Schroeder, Wei-Nchih Lee, Jermyn See, Mohammad Madjid, Mrudula R. Munagala, John D. Piette, Litjen Tan, Orly Vardeny, Michael Greenberg, Jan Liska, Monica Mercer, Sandrine Samson
Summary: This personalized, evidence-based digital intervention proved effective in increasing vaccination rates among individuals with high-risk cardiovascular diseases. White and Asian individuals were more likely to get vaccinated, while the intervention had less impact on people of color.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Immunology
Jau-Yuan Chen, Szu-Min Hsieh, Shinn-Jang Hwang, Chiu-Shong Liu, Xiaoling Li, Marion Fournier, Ting-Yu Yeh, J. Kevin Yin, Sandrine Samson
Summary: This study evaluated the immunogenicity and safety of high-dose and standard-dose influenza vaccines in older adults in Taiwan. The results showed that the high-dose vaccine had higher immunogenicity for all four influenza strains compared to the standard-dose vaccine, and both vaccines had similar safety profiles.
Article
Biotechnology & Applied Microbiology
Xiaoqiang Liu, Juliana Park, Shengli Xia, Bin Liang, Shuangmin Yang, Yanxia Wang, Olga Syrkina, Nathalie Lavis, Shuzhen Liu, Chenyan Zhao, Jian Ding, Jieqiong Hu, Sandrine Samson, Iris A. de Bruijn
Summary: The safety and immunogenicity of the quadrivalent, split-virion influenza vaccine (Shz QIV) developed in China were assessed. The vaccine showed good tolerability and induced immune responses in different age groups, demonstrating non-inferiority against various strains of influenza virus.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Letter
Immunology
J. Kevin Yin, Rebecca C. Harris, Matthew M. Loiacono, Ayman Chit, Sandrine I. Samson
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: The NUDGE-FLU trial aims to investigate the effectiveness of digitally delivered behavioral nudges in increasing influenza vaccination uptake among older adults. It has randomized 964,870 Danish citizens aged 65 years and above to receive either no nudge or one of 9 electronic letters leveraging different behavioral science strategies. The trial will provide important insights into effective communication strategies to maximize vaccination uptake among high-risk groups.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Modin, Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Brian L. Claggett, Erica L. Dueger, Sandrine I. Samson, Matthew M. Loiacono, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: Digital behavioral nudges, such as electronic letters, emphasizing the potential cardiovascular benefits of influenza vaccination and using a reminder letter strategy, were found to be effective in increasing influenza vaccine uptake among older adults both with and without cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Rebecca C. Harris, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study analyzed the effects of two behavioral nudging letter strategies on influenza vaccination rates in patients with heart failure (HF). The results showed that the vaccination rate in HF patients was relatively low, but the behavioral nudging letter strategies were effective in increasing the vaccination rate and had no negative impact on the use of guideline-directed medical therapy (GDMT) in the long term.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Kober, Scott Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study investigated whether behavioural nudges delivered via a governmental electronic letter system could increase influenza vaccination uptake among older adults in Denmark. The results showed that sending an electronic letter highlighting potential cardiovascular benefits of vaccination or sending repeated letters at randomisation and at day 14 significantly improved vaccination rates.
Review
Immunology
Jason K. H. Lee, Gary K. L. Lam, J. Kevin Yin, Matthew M. Loiacono, Sandrine I. Samson
Summary: This updated systematic review and meta-analysis assessed the relative performance of high-dose inactivated influenza vaccine (HD-IIV) and standard-dose influenza vaccines (SD-IIV) against influenza-associated outcomes in older adults (& GE;65 years). The analysis included studies conducted over 12 influenza seasons and showed that HD-IIV provided significantly better protection than SD-IIV against influenza-related outcomes. Subgroup analyses further demonstrated the consistent superiority of HD-IIV across different age groups and strains of influenza.
Article
Medicine, Research & Experimental
Niklas Dyrby Johansen, Daniel Modin, Joshua Nealon, Sandrine Samson, Camille Salamand, Carsten Schade Larsen, Brian L. Claggett, Scott D. Solomon, Martin J. Landray, Gunnar H. Gislason, Lars Kober, Jens Ulrik Staehr Jensen, Pradeesh Sivapalan, Lasse Skafte Vestergaard, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study aims to investigate the feasibility of a pragmatic clinical trial in Denmark comparing high-dose and standard-dose influenza vaccines. The study utilizes existing vaccination infrastructure and the Danish nationwide health registries for data collection. The results will provide valuable insights for future vaccine trials and other interventions.
PILOT AND FEASIBILITY STUDIES
(2022)
