Review
Medicine, General & Internal
Flavia M. Correa, Arn Migowski, Liz M. De Almeida, Marcelo A. Soares
Summary: This review discusses the current strategies in Brazil for screening, treatment, and prevention (HPV vaccination) against cervical cancer, highlighting the country's large public health system and the disparities in access to healthcare. It also explores the potential integration of newer technologies to eliminate cervical cancer.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Asami Yagi, Yutaka Ueda, Mamoru Kakuda, Satoshi Nakagawa, Kosuke Hiramatsu, Ai Miyoshi, Eiji Kobayashi, Toshihiro Kimura, Megumi Kurosawa, Manako Yamaguchi, Sosuke Adachi, Risa Kudo, Masayuki Sekine, Yukio Suzuki, Akiko Sukegawa, Sayaka Ikeda, Etsuko Miyagi, Takayuki Enomoto, Tadashi Kimura
Summary: Despite the widely accepted national immunization program for HPV vaccination in Japan, the suspension of government recommendation due to adverse events led to a drastic drop in vaccination rates. Even with the introduction of a new vaccine, Japanese mothers remain hesitant, and it is crucial for educational and medical institutions to work harder in informing parents and children about the benefits of HPV vaccines.
Article
Engineering, Biomedical
Liming Zhang, Kun Wang, Yuheng Huang, Hui Zhang, Long Zhou, Ang Li, Yunyan Sun
Summary: A novel HPV nanovaccine combining nanotechnology and photodynamic therapy was constructed, which could effectively inhibit the progression of cervical cancer and was experimentally demonstrated in a mouse model.
Article
Oncology
Jacqueline M. Mix, Mona Saraiya, Trevor D. Thompson, Troy D. Querec, April Greek, Thomas C. Tucker, Edward S. Peters, Charles F. Lynch, Brenda Y. Hernandez, Glenn Copeland, Marc T. Goodman, Elizabeth R. Unger
Summary: The study compared HPV prevalence among high-grade cervical precancers and invasive cervical cancers before and after HPV vaccine availability. No significant reduction in vaccine-type prevalence was observed between the two studies, likely due to low HPV vaccination coverage among women in the postvaccine study. Monitoring HPV-type prevalence through population-based strategies remains important for evaluating the impact of the HPV vaccine.
Article
Immunology
Bent Steenberg, Nellie Myburgh, Andile Sokani, Nonhlanhla Ngwenya, Portia Mutevedzi, Shabir A. Madhi
Summary: COVID-19 immunization programs have been rolled out globally on an unprecedented scale. This article highlights the challenges faced in achieving vaccine acceptance in Soweto, South Africa. Despite normative hypothetical acceptance, vaccine uptake remains concerningly low in South Africa, particularly in Soweto. Factors such as distrust towards authorities and misinformation have contributed to hesitancy and denialism among the public. Stated intent to immunize does not necessarily translate to actual behavior. Unveiling and addressing barriers to vaccine confidence and selectivity is crucial, especially in lower-income groups with specific cultural, spiritual, historical, and socioeconomic contexts. Effective media communication and debunking of false claims are essential in promoting immunization.
Article
Public, Environmental & Occupational Health
Jiao Pei, Ting Shu, Chenyao Wu, Mandi Li, Minghan Xu, Min Jiang, Cairong Zhu
Summary: This study evaluated the early effect of the HPV vaccine on cervical cancer and found that the incidence of cervical cancer increased in age groups not receiving the vaccine while remained stable in vaccinated age groups.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Chemistry, Multidisciplinary
Momeneh Ghanaat, Nasser Hashemi Goradel, Arash Arashkia, Nasim Ebrahimi, Sajjad Ghorghanlu, Ziba Veisi Malekshahi, Esmail Fattahi, Babak Negahdari, Hami Kaboosi
Summary: Persistent infection with high-risk types of HPV is known to be the leading cause of cervical cancer, leading to the development of various therapeutic approaches, with adenovirus vectors drawing attention due to their strong immunogenicity and safety.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Immunology
Nelly Mugo, Linda O. Eckert, Lydia Odero, Stephen Gakuo, Kenneth Ngure, Connie Celum, Jared M. Baeten, Ruanne V. Barnabas, Anna Wald
Summary: HIV-infected children showed a sustained antibody response following HPV vaccination. Further research is needed to determine whether HIV-infected children are protected from HPV acquisition with low levels of HPV antibodies.
Article
Immunology
Miriam Gorgone, Andrea Squeri, Sara Cuffari, Vincenza La Fauci, Ioselita Giunta, Serena Calderone, Raffaele Squeri, Cristina Genovese
Summary: Cervical cancer screening adherence and HPV vaccination coverage in Italy are inadequate, likely due to communication and awareness issues, as well as lack of data from private tests. The introduction of HPV-DNA testing helps identify positive women with the most common genotypes associated with neoplastic lesions, as well as other genotypes worth investigating.
Article
Oncology
Cari van Schalkwyk, Jennifer Moodley, Alex Welte, Leigh F. Johnson
Summary: Despite the national screening policy in South Africa since 2000, the incidence of cervical cancer has shown no signs of decline. Research suggests that current prevention measures could reduce cervical cancer incidence in the future, but improvements to the screening strategy are necessary to achieve WHO's prevention targets.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Immunology
Darcy White Rao, Cara J. Bayer, Gui Liu, Admire Chikandiwa, Monisha Sharma, Christine L. Hathaway, Nicholas Tan, Nelly Mugo, Ruanne Barnabas
Summary: The study shows that single-visit screening strategies can reduce a substantial burden of cervical cancer and accelerate progress towards elimination in settings with high HIV burden. Increasing screening frequency among women with HIV and reducing loss-to-follow-up for treatment are key components of a successful elimination strategy.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Article
Immunology
Diana Wangeshi Njuguna, Nour Mahrouseh, Osarugue Victory Isowamwen, Orsolya Varga
Summary: The study found that children had limited knowledge about HPV infection and vaccination, most participants opposed vaccination of boys, parents and community members had negative attitudes towards HPV vaccination, and similar patterns of inadequate knowledge and strong opposition were observed in both Mombasa and Tana-River.
Article
Public, Environmental & Occupational Health
Juman Rezqalla, Mariam Alshatti, Amna Ibraheem, Danah Omar, Al-Failakawi Houda, Shamayel AlHaqqan, Sarah AlGhurair, Saeed Akhtar
Summary: This study found high levels of unawareness among female schoolteachers regarding the causal role of HPV in cervical cancer and the availability of HPV vaccine. Participants who were younger and had lower family incomes were more likely to be unaware of HPV's role in cervical cancer. Additionally, participants with a family or personal history of cervical cancer were less likely to be unaware of HPV's causal role.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Immunology
Mariko Taniguchi, Yutaka Ueda, Asami Yagi, Ai Miyoshi, Yusuke Tanaka, Ryoko Minekawa, Masayuki Endo, Takuji Tomimatsu, Kei Hirai, Tomio Nakayama, Tadashi Kimura
Summary: Women born between 1994 and 1999 with high HPV vaccination rates in Japan are now at the age for cervical cancer screening. Research showed that vaccinated women had better health awareness, while unvaccinated women were more influenced by fear of cancer. Tailored leaflets recommending screening increased rates slightly for both groups, indicating potential for improving cervical cancer control measures tailored to HPV vaccination status.
Review
Medicine, General & Internal
Petmore Zibako, Mbuzeleni Hlongwa, Nomsa Tsikai, Sarah Manyame, Themba G. Ginindza
Summary: Cervical cancer is the leading cause of death among women in low-income countries, but can be eradicated with proper control strategies. This scoping review aims to understand the current status of cervical cancer management in sub-Saharan Africa and provide guidance for policymakers to formulate appropriate cancer management policies. The findings of this study will contribute to global efforts in combating cervical cancer.
SYSTEMATIC REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Aya Avishai, Noel T. Brewer, Jennifer R. Mendel, Paschal Sheeran
Summary: This research examines the mechanism of cognitive activation, where interventions increase the impact of pre-existing cognitions on behavior. The study found that health messages on cigarette packs increased smokers' sensitivity to threat appraisals and led to an increase in smoking restraint.
PSYCHOLOGY & HEALTH
(2023)
Article
Substance Abuse
Seth M. Noar, Nisha Gottfredson, Rhyan N. Vereen, Rachel Kurtzman, Jennifer Mendel Sheldon, Elizabeth Adams, Marissa G. Hall, Noel T. Brewer
Summary: This study developed a scale to assess the effectiveness of tobacco prevention ads and found that it was a reliable and valid measure. The scale was able to predict the potential impact of ads on youth and help in the development and selection of more effective campaigns.
Article
Oncology
Melissa B. Gilkey, Jennifer Heisler-MacKinnon, Marcella H. Boynton, William A. Calo, Jennifer L. Moss, Noel T. Brewer
Summary: A study conducted in the United States found that an enhanced, HPV vaccine-specific quality improvement coaching intervention can lead to long-term improvements in vaccination rates. This intervention, delivered in-person or virtually, proved to be effective in increasing HPV vaccine initiation rates among adolescents.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Infectious Diseases
Fredman Gonzalez, Marta Diez-Valcarce, Yaoska Reyes, Nadja A. Vielot, Christian Toval-Ruiz, Lester Gutierrez, Omar Zepeda, Edwing Centeno Cuadra, Patricia Blandon, Hannah Browne, Natalie M. Bowman, Samuel Vilchez, Jan Vinje, Sylvia Becker-Dreps, Filemon Bucardo
Summary: This study aimed to characterize the timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort. The results showed that most sapovirus infections occurred after 5 months of age and during the second year of life, and re-infections with the same genotype were rare. The study provides insights into the natural history and epidemiology of sapovirus infections in young children.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Public, Environmental & Occupational Health
Eve Dube, Adriana Pistol, Aurora Stanescu, Cassandra Butu, Sherine Guirguis, Oana Motea, Anca Elvira Popescu, Alexandra Voivozeanu, Miljana Grbic, Marie-Eve Trottier, Noel T. Brewer, Julie Leask, Bruce Gellin, Katrine Bach Habersaat
Summary: This study aimed to investigate the barriers and drivers of measles vaccination in Romania, focusing on the experiences of caregivers and health workers. The findings highlighted the importance of following recommended practices for vaccination service delivery and providing sufficient information to caregivers. Key barriers were identified, including shortcomings in vaccination consultations and knowledge gaps among caregivers. The study provides insights for designing interventions to improve vaccination service delivery and enhance the capacity of health workers.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Immunology
Jonathan Fix, Nadja A. Vielot, Jennifer L. Lund, David J. Weber, Jennifer S. Smith, Michael G. Hudgens, Sylvia Becker-Dreps
Summary: The CDC recommends RZV vaccination for adults ??? 50 years to prevent herpes zoster. Immunocompromised adults had higher RZV initiation rates. RZV uptake was low in the two years following the CDC recommendation, with variations influenced by demographic, healthcare access, and clinical characteristics. Despite no CDC recommendation, immunocompromised individuals had higher initiation rates, and our findings may inform efforts to increase RZV uptake in high-risk individuals.
Article
Biotechnology & Applied Microbiology
Kunal Saxena, Niranjan Kathe, Poorva Sardana, Lixia Yao, Ya-Ting Chen, Noel T. Brewer
Summary: The US Advisory Committee on Immunization Practice recommends routine HPV vaccination starting at 11-12 years, but states that it can be initiated as early as 9 years. A study found that initiating HPV vaccination at 9-10 years of age was associated with a higher rate of series completion by 13 years of age compared to initiating at 11-12 years of age. Factors such as provider type, health care plan, sex, race/ethnicity, and wellness checks or non-HPV vaccinations were associated with series completion by 13 years of age.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Oncology
Lisa P. Spees, Caitlin B. Biddell, Jennifer S. Smith, Andrea C. Des Marais, Michael G. Hudgens, Busola Sanusi, Sarah Jackson, Noel T. Brewer, Stephanie B. Wheeler
Summary: This study evaluated the cost-effectiveness of mailing HPV self-collection kits to underscreened individuals. The results showed that mailing HPV self-collection kits was more cost-effective and increased screening uptake compared to scheduling assistance and usual care.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Immunology
Yaoska Reyes, Denise T. St Jean, Natalie M. Bowman, Fredman Gonzalez, Slavica Mijatovic-Rustempasic, Sylvia Becker-Dreps, Lennart Svensson, Johan Nordgren, Filemon Bucardo, Nadja A. Vielot
Summary: In a vaccinated Nicaraguan birth cohort, children with the nonsecretor phenotype had a lower risk of clinical rotavirus vaccine failure.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Richard M. Carpiano, Timothy Callaghan, Renee DiResta, Noel Brewer, Chelsea Clinton, Alison P. Galvani, Rekha Lakshmanan, Wendy E. Parmet, Saad B. Omer, Alison M. Buttenheim, Regina M. Benjamin, Arthur Caplan, Jad A. Elharake, Lisa C. Flowers, Yvonne A. Maldonado, Michelle M. Mello, Douglas J. Opel, Daniel A. Salmon, Jason L. Schwartz, Joshua M. Sharfstein, Peter J. Hotez
Article
Multidisciplinary Sciences
Neetu A. Abad, Seth Messinger, Qian Huang, Megan Hendrich, Nataly Johanson, Helen Fisun, Zachary E. Lewis, Elisabeth Wilhelm, Brittney T. Baack, Kimberly Bonner, Rosemarie Kobau, Noel Brewer
Summary: Around one-third of Americans were unwilling to get a COVID-19 vaccine in April 2021. A focus group study with 59 vaccine-hesitant adults identified lack of trust in experts and institutions, safety concerns, resistance to guidance, and acceptance of others getting vaccinated as key factors contributing to vaccine hesitancy. Vaccine confidence communication strategies should address individual concerns, highlight benefits, and foster trust through factual and neutral information.
Article
Biotechnology & Applied Microbiology
Benjamin Z. Kahn, Paul L. Reiter, Katherine I. Kritikos, Melissa B. Gilkey, Tara L. Queen, Noel T. Brewer
Summary: Proactive HPV vaccination at age 9 is more effective in preventing infection and completing the vaccine series. The study assessed the impact of different HPV vaccine recommendation frames on healthcare providers' willingness to recommend vaccines for children. Recommending vaccination at ages 11-12 resulted in lower willingness to vaccinate at ages 9-10, while recommending vaccination at ages 9 led to higher willingness. Aligning national recommendations to start at age 9 can promote timely vaccination.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Infectious Diseases
Evelin Martinez, Ryan Max, Filemon Bucardo, Elizabeth M. Stringer, Sylvia Becker-Dreps, Christian Toval-Ruiz, Meylin Chavarria, Maria J. Melendez-Balmaceda, Carlos Nunez, Matthew H. Collins, Michael Boivin, Shiara Ortiz-Pujols, Omar Zepeda, Kaitlyn Cross, Emily W. Gower, Natalie M. Bowman, Sara F. Grace
Summary: Children exposed to Zika virus (ZIKV) in utero without Congenital Zika Syndrome (CZS) may have visual impairments in early childhood. A study in Nicaragua found that 19.4% of ZIKV-exposed children and 5.2% of unexposed children had abnormal visual function.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Microbiology
Nadja Alexandra Vielot, Omar Zepeda, Yaoska Reyes, Fredman Gonzalez, Jan Vinje, Sylvia Becker-Dreps, Filemon Bucardo
Summary: Norovirus is a common cause of pediatric acute gastroenteritis worldwide, but there are currently no available vaccines. A case-control study conducted in Nicaragua found that risk factors for norovirus gastroenteritis included having a dirt floor in the home and recent contact with someone with AGE symptoms.
Article
Public, Environmental & Occupational Health
Denise T. T. St Jean, Jessie K. K. Edwards, Elizabeth T. Rogawski T. McQuade, Peyton Thompson, James C. C. Thomas, Sylvia Becker-Dreps
Summary: This study examines the efficacy of an oral rotavirus vaccine in different settings. The researchers use a weight-based method to transport the trial results to the target population, and find that the efficacy increases after adjusting for population characteristics.
EPIDEMIOLOGY AND INFECTION
(2023)
