期刊
VACCINE
卷 28, 期 4, 页码 907-915出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.11.002
关键词
Influenza; B cell; Hemagglutinin
资金
- HHS/NIH/NIAID [N01-A125460, HHSN266200700008C, N01-A150020]
B cell responses after immunization with a drifted H5 influenza/A/Vietnam/1203/04 vaccine were characterized in the peripheral blood of human subjects primed with experimental recombinant H5 influenza A/Hong Kong/156/97 vaccine Antibody secreting cells were assayed by ELISPOT against a panel of recombinant hemagglutinin and control proteins Increased frequencies of H5 HA-specific antibody secreting and memory B cells could be observed within 7 days of re-vaccination. Furthermore, these responses were cross-reactive to both H5 HA variants, but not H3 or avian H6 HA strains These observations Suggest prior vaccination against H5 influenza HA induces cellular immune responses that cross-react among drifted variants, without precluding a response to new, or existing HA strains (C) 2009 Elsevier Ltd All rights reserved
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