Article
Immunology
Coen A. L. Stalpers, Irene A. Retmana, Jeroen L. A. Pennings, Rob J. Vandebriel, Coenraad F. M. Hendriksen, Arnoud M. Akkermans, Marcel H. N. Hoefnagel
Summary: The study quantified the variability of in vivo potency release assays for four DTaP products from different manufacturers, revealing a large range of CV which limits their value in ensuring potency consistency. Despite high variability in individual test results, DTaP batches showed great consistency in manufacturing processes across different batches.
Article
Public, Environmental & Occupational Health
Forrest K. Jones, Keitly Mensah, Jean-Michel Heraud, Fidiniaina Mamy Randriatsarafara, C. Jessica E. Metcalf, Amy Wesolowski
Summary: The study reveals that while initial vaccine coverage in children is high, subsequent doses tend to decrease. There is no consistent difference in coverage levels between urban and rural areas. Interestingly, a significant proportion of individuals receive late doses for certain vaccines.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Immunology
Lise Boey, Eline Bosmans, Liane Braz Ferreira, Nathalie Heyvaert, Melissa Nelen, Lisa Smans, Hanne Tuerlinckx, Mathieu Roelants, Kathleen Claes, Inge Derdelinckx, Wim Janssens, Chantal Mathieu, Johan Van Cleemput, Robin Vos, Isabelle Desombere, Corinne Vandermeulen
Summary: Patients with chronic diseases showed insufficient vaccine protection against diphtheria and pertussis, with factors like vaccination timing and age impacting the antibody levels. Tetanus, however, had higher protection rates among at-risk patients, especially when vaccinated within the last ten years.
Review
Immunology
Bahaa Abu-Raya, Kirsten Maertens, Flor M. Munoz, Petra Zimmermann, Nigel Curtis, Scott A. Halperin, Nynke Rots, Daan Barug, Beth Holder, Beate Kampmann, Elke Leuridan, Manish Sadarangani
Summary: Infants of Tdap-immunized women in pregnancy showed lower IgG levels against pertussis, diphtheria, and some SPN serotypes after their immunization compared to infants of unimmunized women. Enhanced surveillance of pertussis, diphtheria, and IPD in infants is needed to determine the clinical significance of these findings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Asmik Asatryan, Nadia Meyer, Michael Scherbakov, Victor Romanenko, Irina Osipova, Anna Galustyan, Olga Shamsheva, Tatiana Latysheva, Tatyana Myasnikova, Nathalie Baudson, Monique Dodet, Stebin Xavier, Lauriane Harrington, Anastasia Kuznetsova, Laura Campora, Peter Van den Steen
Summary: Administering the dTpa vaccine as a booster dose in healthy Russian participants induced a robust immune response to all vaccine antigens and was generally well tolerated across all age groups.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Laura Maria Rivera-Santamaria, Doracelly Hincapie-Palacio, Jesus Ochoa, Felipe Vargas-Restrepo, Marta C. Ospina, Seti Buitrago-Giraldo
Summary: The study showed that vaccination with Tdap during pregnancy can provide protection to both mothers and newborns, with maternal antibodies being effectively transferred to the newborns, indicating the importance of vaccination during pregnancy.
Article
Immunology
John Hansen, Michael D. Decker, Edwin Lewis, Bruce Fireman, Vitali Pool, David P. Greenberg, David R. Johnson, Steven Black, Nicola P. Klein
Summary: This study found that the rate of HHE after administration of acellular pertussis vaccines was approximately 22.8 per 100,000 doses, lower than the rates reported after whole cell pertussis vaccines and consistent with other studies on acellular pertussis vaccines.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Immunology
Inci Aydin, Marcus May, Fabio Pisano, Nontsikelelo Mpofu-Maetzig, Leander Grode, Sameer Parekh, Pramod Pujari, Sunil Shewale, Shivani Desai, Hitt Sharma, Harish Rao, Manish Gautam, Sunil Gairola, Umesh Shaligram
Summary: This study evaluated the safety and immunogenicity of a new booster vaccine manufactured by Serum Institute of India Pvt. Ltd (SIIPL Tdap) against tetanus, diphtheria, and pertussis. The results showed that SIIPL Tdap is non-inferior to the comparator Tdap in terms of safety and immunogenicity, with higher antibody concentrations.
Review
Pediatrics
James D. Cherry, Saba Doustmohammadi
Summary: This review emphasizes the importance of universal pertussis vaccination in controlling the cough illness. Recent findings show a significant decrease in pertussis cases and deaths in children, highlighting the potential of adolescent/adult vaccines in further reducing morbidity and mortality.
CURRENT OPINION IN PEDIATRICS
(2022)
Article
Medicine, Research & Experimental
Violaine Dubois, Jonathan Chatagnon, Manon Depessemier, Camille Locht
Summary: Maternal aP vaccination can protect infants from lung colonization by Bordetella pertussis, but it leads to prolonged nasal carriage of the bacteria and increases the risk of infection. This effect can be transferred to the offspring through the placenta or breastfeeding and persists into adulthood.
Article
Medicine, Research & Experimental
Violaine Dubois, Manon Depessemier, Camille Locht
Summary: A study using a mouse model found that maternal acellular pertussis vaccination protects pups from lung infection, but prolongs the nasal carriage of Bordetella pertussis and potentially leads to inflammation. This effect can be transferred to offspring either through the placenta or via breastfeeding, and persists into adulthood.
Article
Immunology
Clarisse Marchal, Manon Belhassen, Nicole Guiso, Flore Jacoud, Eric Van Ganse, Marie Le Pannerer, Robert Cohen, Regis Verdier, Mathieu Uhart
Summary: From 2013 to 2017, the booster vaccination coverage rates for Diphtheria, Tetanus, Poliomyelitis, and Pertussis in France have increased, but remain suboptimal, particularly in adult populations. The introduction of a pertussis vaccination at age 6 in 2013 was relatively well-established by 2017, while other recommendations were slowly or partially implemented.
Article
Public, Environmental & Occupational Health
Christine Stabell Benn, Nelly Amenyogbe, Anders Bjorkman, Jorge Dominguez-Andres, Eleanor N. Fish, Katie L. Flanagan, Sabra L. Klein, Tobias R. Kollmann, Kirsten Ohm Kyvik, Mihai G. Netea, Naja Hulvej Rod, Frederik Schaltz-Buchholzer, Frank Shann, Liisa Selin, Sanne M. Thysen, Peter Aaby
Summary: The current framework for testing and regulating vaccines needs to be updated to consider the non-specific effects of vaccines, which can affect all-cause mortality and morbidity in ways that are not explained by the prevention of the targeted disease. Immunological studies have provided mechanisms that explain how vaccines might modulate the immune response to unrelated pathogens. Non-specific effects are often greater in female individuals. Currently, these effects are not routinely captured in clinical trials or post-licensure safety surveillance, but a new framework is proposed to address this issue.
Article
Immunology
Claudio Costantino, Walter Mazzucco, Nicole Bonaccorso, Livia Cimino, Arianna Conforto, Martina Sciortino, Gabriele Catalano, Maria Rosa D'Anna, Antonio Maiorana, Renato Venezia, Giovanni Corsello, Francesco Vitale
Summary: A study conducted in Italy found that educational interventions on maternal immunization, including counseling by healthcare professionals, significantly improved vaccination adherence among pregnant women during pregnancy.
Article
Biotechnology & Applied Microbiology
Dandan Liu, Xiaoping Cheng, Shi Wei, Lin Yuan, Changhui Chen, Kaihu Yao
Summary: The study in China revealed the immunity levels against diphtheria, tetanus, and pertussis, showing susceptibility in young infants and adults and low immunity to pertussis across all age groups. This highlights the need to enhance the current vaccination program.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)