Article
Biochemistry & Molecular Biology
Bishajit Sarkar, Md. Asad Ullah, Yusha Araf, Sowmen Das, Md. Hasanur Rahman, Abu Tayab Moin
Summary: HSV is a highly infectious virus with two types, HSV-1 and HSV-2, infecting millions worldwide. This study designed three polyvalent subunit vaccines targeting multiple strains of HSV, which showed stability and potential effectiveness through molecular docking and simulation studies. Validation of these vaccines in wet lab-based studies is still needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Virology
Brent A. Stanfield, Konstantin G. Kousoulas, Agustin Fernandez, Edward Gershburg
Summary: Diseases caused by human herpes simplex virus types 1 and 2 affect millions worldwide, but there are currently no FDA-approved vaccines. The development of novel live-attenuated vaccines aims to prevent or reduce the impact of herpes simplex infections, building on the success of past live-attenuated vaccines in combating viral diseases. These vaccines are designed to generate robust and protective immune responses based on our understanding of the immunopathogenesis of herpesviral infections.
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Virology
Isadora Zhang, Zoe Hsiao, Fenyong Liu
Summary: Herpes simplex virus 1 (HSV-1) can cause cold sores or keratitis in healthy individuals, but severe complications in immune-compromised or neonatal patients. Current therapies can block viral replication but have limited effect on viral latency, necessitating the development of new strategies. Genome editing methods like homing endonucleases and CRISPR/Cas systems show promise in inhibiting HSV-1 infection.
Article
Ophthalmology
Sanya Yadav, Patrick Commiskey, Regis P. Kowalski, Vishal Jhanji
Summary: This study retrospectively reviewed cases of HSV-2 blepharokeratoconjunctivitis between 1995 and 2021, finding that while HSV-2 is an uncommon cause of keratitis, recurrence can still occur despite antiviral prophylaxis.
CURRENT EYE RESEARCH
(2022)
Review
Virology
Nathan B. Price, Kelly E. Wood
Summary: Deaths from herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are rare, with perinatal acquisition of HSV-1 or HSV-2 leading to substantial neonatal death rates. In the cases of dual deaths of pregnant women and their newborns from herpesvirus infection, most were caused by HSV-2. Interestingly, some cases indicated possible non-sexual transmission of HSV-1 from children to pregnant women.
Review
Immunology
Shiza Malik, Ranjit Sah, Omar Ahsan, Khalid Muhammad, Yasir Waheed
Summary: Research on herpes simplex virus (HSV) indicates that current antiviral therapies can alleviate symptoms and control viral transmission, but they cannot eradicate HSV infection and latency. The complex nature of the virus requires continued efforts to develop new treatment methods to control its spread and mutations.
Article
Immunology
Aakash Mahant, Sandra Guerguis, Tamara P. Blevins, Natalia Cheshenko, Wei Gao, Kathryn Anastos, Robert B. Belshe, Betsy C. Herold
Summary: The AS04 glycoprotein D vaccine failed to prevent HSV-2 by eliciting neutralizing antibodies, with limited ADCC responses in acutely infected individuals. However, individuals with chronic HSV-2 infection showed significant ADCC responses targeting a broader range of viral antigens, indicating the importance of polyfunctional ADCC responses in preventing HSV-2 acquisition and recurrences.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Fanghui Ren, Ryo Narita, Ahmad S. Rashidi, Stefanie Fruhwurth, Zongliang Gao, Rasmus O. Bak, Martin K. Thomsen, Georges M. G. M. Verjans, Line S. Reinert, Soren R. Paludan
Summary: Neurotropic viruses such as herpes simplex virus (HSV) can infect neurons and cause severe diseases. HSV-induced neuronal cell death is mediated by gasdermin E (GSDME) and involves endoplasmic reticulum stress, caspase activation, and mitochondria-dependent apoptosis. The necrotic neurons release alarmins, triggering inflammatory responses in microglia.
Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Pietro Giuseppe Mazzara, Elena Criscuolo, Marco Rasponi, Luca Massimino, Sharon Muggeo, Cecilia Palma, Matteo Castelli, Massimo Clementi, Roberto Burioni, Nicasio Mancini, Vania Broccoli, Nicola Clementi
Summary: This study has developed a stable and reliable in vitro system that models the connectivity between different human sensory neurons and peripheral tissues. By analyzing the infection process of herpes simplex virus 1 (HSV-1), it provides a better understanding of viral latency and reactivation at the cellular and molecular levels.
Article
Virology
Petra Bergstrom, Edward Trybala, Charlotta E. Eriksson, Maria Johansson, Tugce Munise Satir, Sibylle Widehn, Stefanie Fruhwurth, Wojciech Michno, Faisal Hayat Nazir, Jorg Hanrieder, Soren Riis Paludan, Lotta Agholme, Henrik Zetterberg, Tomas Bergstrom
Summary: The study demonstrates that human induced pluripotent stem cells (iPSCs) differentiated into cortical neurons can be infected with clinical strains of HSV-1 and HSV-2. While both viruses decrease the viability of neuroprogenitors, cortical neurons show resilience to infection. However, in functional neurons, both HSV-1 and HSV-2 affect gene expression of synaptic activity markers and negatively impact synaptic activity.
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giuseppe Pezzotti, Eriko Ohgitani, Saki Ikegami, Masaharu Shin-Ya, Tetsuya Adachi, Toshiro Yamamoto, Narisato Kanamura, Elia Marin, Wenliang Zhu, Kazu Okuma, Osam Mazda
Summary: Hydrolytic reactions on the surface of Si3N4 bioceramic can instantaneously inactivate HHV-1 due to the direct reaction between ammonia and its nitrogen radical byproducts produced during Si3N4 hydrolysis and viral proteins, leading to irreversible damage to the virus DNA and structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
