期刊
VACCINE
卷 27, 期 36, 页码 5013-5019出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.05.009
关键词
Helicobacter pylori; Epitope vaccine; Therapeutic immunization
资金
- National Natural Science Foundation of China [30771992]
- Chongqing Natural Science Foundation [2007BB5007]
Epitope vaccine is a promising option for therapeutic vaccination against Helicobacter pylon (H. pylori) infection. In this study, we constructed a multi-epitope vaccine with five epitopes and mucosal adjuvant E. coli heat-labile enterotoxin B subunit (LTB) named HUepi-LTB and evaluated its therapeutic effect against H. pylori infection in BALB/c mice model. HUepi-LTB containing three Th epitopes from UreB and two B cell epitopes from UreB and HpaA was constructed and expressed in E. coli. Oral therapeutic immunization with HUepi-LTB significantly decreased H. pylori colonization compared with oral immunization with PBS, and the protection was correlated with antigen-specific CD4(+) T cells and IgG and mucosal IgA antibody responses. This multi-epitope vaccine may be a promising vaccine candidate that may help to control H. pylon infection. (C) 2009 Elsevier Ltd. All rights reserved.
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