期刊
VACCINE
卷 27, 期 52, 页码 7385-7393出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.09.021
关键词
Influenza vaccine; VLP; Adenovirus dodecahedron
资金
- Polish Ministry of Education and Computer Sciences (MNII) [2504B0232]
- NATO CLG [982385]
We propose a novel influenza vaccine composed of the adenovirus dodecahedron (Dd) as delivery platform carrying an internal influenza matrix protein M1. To attach the antigen to the vector we used WW domains interacting with Dd. Successful internalization of the Dd-M1WW complex was observed using biochemical and cell biology techniques. We show here that the complex of Dd with antigen is a potent activator of human myeloid dendritic cells (MDC), and that it is efficiently presented by MDC to M1-specific CD8+ T lymphocytes. These results show that proposed vaccine model is feasible and that adenovirus dodecahedron is a potent delivery platform for foreign antigens to human cells. (C) 2009 Elsevier Ltd. All rights reserved.
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