期刊
VACCINE
卷 27, 期 33, 页码 4483-4489出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.05.034
关键词
Concomitant vaccination; IC51; Japanese encephalitis; Travel; Hepatitis A; Interaction
In travellers often several pre-departure immunizations are indicated, thus data are needed about possible interactions between vaccines. This Phase 3 study investigated the immunogenicity and safety of IC51 (JE vaccine) and HAVRIX (R) 1440 (hepatitis A vaccine) when administered alone or concomitantly to healthy subjects. The immune response was compared between single and concomitant vaccination in terms of geometric mean titre (GMT) and seroconversion rate (SCR) on Days 28 and 56. Immunogenicity was comparable for the 2 vaccines whether given together or separately which suggests that travellers to such regions could receive the vaccinations concomitantly. (C) 2009 Elsevier Ltd. All rights reserved.
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