Article
Immunology
Katerina Rok Song, Jacqueline Kyungah Lim, Se Eun Park, Tarun Saluja, Sung-Il Cho, Tram Anh Wartel, Julia Lynch
Summary: Both efficacy and effectiveness studies of vaccines help to understand the impact of vaccines in real-world settings, with vaccines used in public health programs potentially showing higher effectiveness due to indirect herd protection.
Article
Biotechnology & Applied Microbiology
Patricia Izurieta, Michael Scherbakov, Javier Nieto Guevara, Volker Vetter, Lamine Soumahoro
Summary: This systematic review evaluated the efficacy, effectiveness, and impact of 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) and 13-valent PCV (PCV13) on otitis media outcomes. Statistically significant reductions in all-cause and complicated otitis media were consistently observed after the introduction of both vaccines. Some studies suggest PHiD-CV may offer better protection against certain otitis media outcomes, highlighting the need for further research in this area.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Ron Dagan, Bart Adriaan van der Beek, Shalom Ben-Shimol, Tamara Pilishvili, Noga Givon-Lavi
Summary: The study demonstrates that the 7-valent and 13-valent pneumococcal vaccines are effective in protecting against otitis media caused by specific serotypes, especially serotypes 19F and 19A.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Janine Paynter, Anna S. Howe, Emma Best, Helen Petousis-Harris
Summary: This study used New Zealand's linkable, administrative health data to examine the comparative risk of otitis media (OM) and pneumonia hospitalisations among children receiving three different pneumococcal conjugate vaccines (PCV). The results showed that PCV10 was associated with a reduced risk for OM compared with PCV7. There were no significant differences between PCV10 and PCV13 in risk of hospitalisation with either otitis media or all-cause pneumonia amongst the transition 2 cohort. In the 18-month follow-up after transition 3, PCV13 was associated with a marginally higher risk of all-cause pneumonia and otitis media compared to PCV10.
Article
Pediatrics
Oren Ziv, Dana Adelson, Reem Sadeh, Sofia Kordeluk, Sabri El-Saied, Eugene Leibovitz, Mordechai Kraus, Daniel Kaplan
Summary: This retrospective cohort study showed that immunization with pneumococcal conjugate vaccines (PCV) significantly reduced the occurrence of recurrent acute otitis media (rAOM) in infants following an early episode of acute otitis media (AOM).
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Otorhinolaryngology
Thanakrit Wannarong, Pichamon Ekpatanaparnich, Adhiratha Boonyasiri, Orawan Supapueng, Vannipa Vathanophas, Archwin Tanphaichitr, Kitirat Ungkanont
Summary: The study assessed the effect of the pneumococcal vaccine on the surgical management and complications of otitis media. The results showed that the pneumococcal vaccine significantly reduced the rate of tympanostomy tube insertion and recurrent acute otitis media in children, but had no significant effect on the incidence of otitis media with effusion.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Immunology
Nathaniel M. Lewis, Jessie R. Chung, Timothy M. Uyeki, Lisa Grohskopf, Jill M. Ferdinands, Manish M. Patel
Summary: This study analyzes the comparability of relative vaccine effectiveness across different studies and suggests that this comparability is dependent on the absolute vaccine effectiveness of the comparator vaccine. These findings have implications for the design of influenza vaccine studies and data reporting.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Economics
Lays P. Marra, Ana L. Sartori, Martha S. Martinez-Silveira, Cristiana M. Toscano, Ana L. Andrade
Summary: This study aimed to evaluate the effectiveness of pneumococcal vaccines on otitis media and acute otitis media in children. The results showed that pneumococcal vaccines play an important role in reducing the incidence of otitis media in children.
Review
Biochemistry & Molecular Biology
Su Young Jung, Dokyoung Kim, Dong Choon Park, Eun Hye Lee, Yong-Sung Choi, Jeewon Ryu, Sang Hoon Kim, Seung Geun Yeo
Summary: Otitis media is caused by various factors including infections, anatomo-physiological abnormalities, allergies, and environmental influences. This study highlights the immune responses in otitis media patients, focusing on antibodies and transcription factors produced by B cells, as well as the important functions of B cells in immune defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ramy Mohamed Ghazy, Ehab Elrewany, Assem Gebreal, Rony Elmakhzangy, Noha Fadl, Eman Hassan Elbanna, Mahmoud M. Tolba, Elsayed Mohamed Hammad, Naglaa Youssef, Hazem Abosheaishaa, Elsayed Eldeeb Mehana Hamouda, Zeyad Elsayed Eldeeb Mehana, Ahmed Saad Al Zomia, Raad Ahmed Alnami, Emad Ali Saeed Salma, Abdulaziz Saleh Alqahtani, Abdulaziz Fayez Alshehri, Mai Hussein
Summary: Monkeypox vaccines generate adequate antibodies, but their effectiveness may decrease over time and exhibit varying safety profiles. Most studies consistently reported high levels of effectiveness against monkeypox. The number of vaccine doses administered affects immunogenicity, and smallpox vaccines provide cross-protection against monkeypox.
Review
Virology
Soo-Young Choi, Dong-Keon Yon, Yong-Sung Choi, Jinseok Lee, Ki-Ho Park, Young-Ju Lee, Sung-Soo Kim, Sang-Hoon Kim, Seung-Geun Yeo
Summary: This review examines the impact of COVID-19 on otitis media and highlights the unexpected positive effects brought about by measures implemented in response to the pandemic. These effects include a drastic reduction in the incidence of otitis media, decrease in antibiotic prescriptions, lower occurrence of complications, and decreased number of patients visiting the emergency room for otitis media. The findings have significant implications for the treatment and prevention of otitis media.
Article
Immunology
Supitcha Kamolratanakul, Punnee Pitisuttithum
Summary: Human papillomavirus (HPV) is the most common sexually transmitted infection, with 15 HPV types related to various cancers. HPV vaccines have been proven to be safe and highly effective in preventing HPV infections and associated cancers, especially among young women. The different types of HPV vaccines have shown similar efficacy in protecting against certain HPV types, with the nonavalent vaccine offering additional protection against more types. HPV vaccination has also been shown to provide herd protection and reduce the prevalence of HPV-related cancers.
Review
Biochemistry & Molecular Biology
Su Young Jung, Dokyoung Kim, Dong Choon Park, Sung Soo Kim, Tong In Oh, Dae Woong Kang, Sang Hoon Kim, Seung Geun Yeo
Summary: Otitis media is mainly caused by upper respiratory tract infection and eustachian tube dysfunction. The expression of Toll-like receptors (TLRs) is closely related to the occurrence, recurrence, chronicization, and complications of otitis media, playing an important role in the early response to external antigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Hye-Young Kim, Seong-Beom Park, Eun-Sil Kang, Sang-Min Lee, Hyun-Jin Kim, Matt Wasserman
Summary: The study showed that introducing PCV13 into the national immunization program in South Korea was estimated to have a greater impact and be more cost-effective compared to PCV10. This was mainly due to the broader serotype coverage of PCV13, leading to more cases of pneumococcal disease being averted and cost-saving.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Sung-Won Choi, Se-Joon Oh, Yehree Kim, Min Young Kwak, Myung-Whan Suh, Moo Kyun Park, Chi Kyou Lee, Hong Ju Park, Soo-Keun Kong
Summary: The study demonstrated that navigation-guided balloon Eustachian tuboplasty is a safe and more effective treatment option compared to medical management alone for patients with chronic Eustachian tube dilatory dysfunction. This conclusion was drawn based on improvements in symptoms, tympanogram results, and air-bone gap differences.
SCIENTIFIC REPORTS
(2021)
