Article
Microbiology
Roberto De Pascalis, Varunika Bhargava, Scott Espich, Terry H. Wu, H. Carl Gelhaus, Karen L. Elkins
Summary: Identifying suitable animal models and standardizing preclinical methods are crucial for developing vaccines against Francisella tularensis. Non-human primates are important animal models for evaluating vaccine efficacy, while Fischer 344 rats are valuable for initial immune response studies and vaccine screening. This study compared three Fischer rat substrains and confirmed their suitability as models for studying Francisella infection and immunity.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Adam Wisnewski, Julian Campillo Luna, Carrie A. Redlich
Summary: Study on 4 subjects showed that COVID-19 mRNA vaccines effectively induce spike antigen-specific IgG and IgA, but there are marked differences in their persistence in serum.
Article
Immunology
Adriana Weinberg, D. Scott Schmid, Jessica Leung, Michael J. Johnson, Congrong Miao, Myron J. Levin
Summary: A comparison between recombinant and live zoster vaccines showed that the recombinant vaccine (RZV) generated higher levels of antibodies and stronger antibody responses than the live vaccine (ZVL), which lasted for more than 5 years. The antibody responses to RZV were also more persistent. This study provides detailed information about antibody responses to the recombinant zoster vaccine.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Rabia Bag Soytas, Mahir Cengiz, Mehmet S. Islamoglu, Betul Borku Uysal, Serap Yavuzer, Hakan Yavuzer
Summary: The study compared the antibody levels of patients aged 60 and older who received different COVID-19 vaccine regimens, showing that the immunity formed after two doses of CoronaVac plus one dose of Pfizer-BioNTech was significantly higher in older adults than after three doses of CoronaVac.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Naranjargal J. Dashdorj, Oliver F. Wirz, Katharina Roltgen, Emily Haraguchi, Anthony S. Buzzanco, Mamdouh Sibai, Hannah Wang, Jacob A. Miller, Daniel Solis, Malaya K. Sahoo, Prabhu S. Arunachalam, Alexandra S. Lee, Mihir M. Shah, James Liu, Sumiya Byambabaatar, Purevjargal Bat-Ulzii, Anir Enkhbat, Enkhtuul Batbold, Delgersaikhan Zulkhuu, Byambasuren Ochirsum, Tungalag Khurelsukh, Ganbold Dalantai, Natsagdorj Burged, Uurtsaikh Baatarsuren, Nomin Ariungerel, Odgerel Oidovsambuu, Andreas S. Bungert, Zulkhuu Genden, Dahgwahdorj Yagaanbuyant, Altankhuu Mordorj, Bali Pulendran, Sharon Chinthrajah, Kari C. Nadeau, Theodore Jardetzky, James L. Wilbur, Jacob N. Wohlstadter, George B. Sigal, Benjamin A. Pinsky, Scott D. Boyd, Naranbaatar D. Dashdorj
Summary: The study found marked differences in antibody responses among individuals in Mongolia vaccinated with different COVID-19 vaccines, with lower levels of antibodies stimulated by the Sinopharm and Sputnik V vaccines. Those who recover from infection after vaccination typically achieve high antibody titers.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Jackson S. Turner, Jane A. O'Halloran, Elizaveta Kalaidina, Wooseob Kim, Aaron J. Schmitz, Julian Q. Zhou, Tingting Lei, Mahima Thapa, Rita E. Chen, James Brett Case, Fatima Amanat, Adriana M. Rauseo, Alem Haile, Xuping Xie, Michael K. Klebert, Teresa Suessen, William D. Middleton, Pei-Yong Shi, Florian Krammer, Sharlene A. Teefey, Michael S. Diamond, Rachel M. Presti, Ali H. Ellebedy
Summary: SARS-CoV-2 mRNA vaccines induce a persistent germinal centre B cell response in humans, leading to the generation of robust humoral immunity, especially more significant in individuals previously infected with the virus.
Article
Infectious Diseases
David W. Eyre, Sheila F. Lumley, Jia Wei, Stuart Cox, Tim James, Anita Justice, Gerald Jesuthasan, Denise O'Donnell, Alison Howarth, Stephanie B. Hatch, Brian D. Marsden, E. Yvonne Jones, David Stuart, Daniel Ebner, Sarah Hoosdally, Derrick W. Crook, Tim E. A. Peto, Timothy M. Walker, Nicole E. Stoesser, Philippa C. Matthews, Koen B. Pouwels, A. Sarah Walker, Katie Jeffery
Summary: The study found that nearly all healthcare workers develop detectable anti-spike antibodies after receiving the Pfizer-BioNTech or Oxford-AstraZeneca vaccines. Those with prior infection and younger age were more likely to test seropositive after the first dose.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Virology
Kaito Nagashima, Nada Abbadi, Ved Vyas, Abigail Roegner, Ted M. Ross, Jarrod J. Mousa
Summary: Computationally optimized broadly reactive antigens (COBRAs) are a promising universal influenza vaccine candidate. In this study, we investigated the effect of different adjuvants on the antibody responses induced by COBRAs. We found that AddaS03 performed the best, eliciting high IgG titers and hemagglutination inhibition (HAI) activity for COBRA immunizations. These findings provide important insights for the development of COBRA-based vaccines in the future.
Article
Immunology
Sian E. Jossi, Melissa Arcuri, Areej Alshayea, Ruby R. Persaud, Edith Marcial-Juarez, Elena Palmieri, Roberta Di Benedetto, Marisol Perez-Toledo, Jamie Pillaye, Will M. Channell, Anna E. Schager, Rachel E. Lamerton, Charlotte N. Cook, Margaret Goodall, Takeshi Haneda, Andreas J. Baumler, Lucy H. Jackson-Jones, Kai-Michael Toellner, Calman A. MacLennan, Ian R. Henderson, Francesca Micoli, Adam F. Cunningham
Summary: Vi-specific IgM or IgG can independently protect against infection, and superior protection from vaccination with TCV in adults may be related to the ability of the response to persist better.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
David Forgacs, Hyesun Jang, Rodrigo B. Abreu, Hannah B. Hanley, Jasper L. Gattiker, Alexandria M. Jefferson, Ted M. Ross
Summary: In this study, a serological assay was used to measure antibody responses post-vaccination and compared to immune responses from natural infection. The results showed that vaccination induced a more robust immune reaction and that levels of neutralizing and anti-RBD antibody binding were significantly higher in pre-immune participants compared to immunologically naive participants.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Iris N. Pardieck, Suzanne van Duikeren, Dominique M. B. Veerkamp, Dena J. Brasem, Anke Redeker, Jeroen van Bergen, Wanda Han, Ferry Ossendorp, Gerben Zondag, Ramon Arens
Summary: This study suggests that the addition of antiviral T cell responses to antibody-eliciting vaccines can enhance immunity to human cytomegalovirus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ji-Young Hwang, Yunhwa Kim, Kyung-Min Lee, Eun-Jeong Jang, Chang-Hoon Woo, Chang-Ui Hong, Seok-Tae Choi, Sivilay Xayaheuang, Jong-Geol Jang, June-Hong Ahn, Hosun Park
Summary: In the face of a global COVID-19 vaccine shortage, an efficient vaccination strategy is required. This study compared the immunogenicity of COVID-19 vaccination in recovered individuals and unvaccinated individuals, as well as in individuals without prior SARS-CoV-2 infection. The results showed that vaccinated recovered individuals had significantly higher immune responses compared to unvaccinated recovered individuals, while antibody responses varied among SARS-CoV-2-naive vaccinees depending on the vaccine type.
Article
Multidisciplinary Sciences
Svenja Weiss, Vincenza Itri, Ruimin Pan, Xunqing Jiang, Christina C. Luo, Lynn Morris, Delphine C. Malherbe, Philip Barnette, Jeff Alexander, Xiang-Peng Kong, Nancy L. Haigwood, Ann J. Hessell, Ralf Duerr, Susan Zolla-Pazner
Summary: The authors demonstrate that an HIV vaccine targeting the V1V2 region of gp120 is superior to whole envelope vaccines or natural infection in inducing V1V2 antibodies with anti-viral functions that correlate with protection.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Hassan Alkharaan, Hatem Al-Qarni, Muath A. Aldosari, Mohammed Alsaloum, Ghada Aldakheel, Mohammed W. Alenazi, Naif Khalaf Alharbi
Summary: Little is known about the salivary mucosal immune response to different types of COVID-19 vaccines or after a booster dose of the BNT162b2 vaccine. Salivary IgG antibody responses were measured in vaccinated individuals, and it was found that different vaccine types and regimens elicit similar levels of salivary anti-SARS-CoV-2 IgG with modest waning over time. Boosting with the BNT162b2 vaccine did not significantly increase mucosal IgG response, highlighting the need for developing oral or intra-nasal vaccines for stronger mucosal immunity.
Article
Immunology
Alexa J. Roeder, Megan A. Koehler, Paniz Jasbi, Davis McKechnie, John Vanderhoof, Baylee A. Edwards, Maria J. Gonzalez-Moa, Alim Seit-Nebi, Sergei A. Svarovsky, Douglas F. Lake
Summary: A third dose of mRNA vaccine elicits higher and more durable neutralizing antibody titers than the second dose, independent of manufacturer, sex, and age. Vaccinated individuals can be categorized as strong, moderate, and poorly neutralizing responders. Neutralizing antibody levels sufficient for protection from early SARS-CoV-2 variants were not protective against Omicron infection and disease. This study highlights the need for accessible vaccine response monitoring to inform vaccination decisions.
Article
Infectious Diseases
Scott M. Baliban, Brittany Curtis, Deanna Toema, Sharon M. Tennant, Myron M. Levine, Marcela F. Pasetti, Raphael Simon
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Microbiology
Moon H. Nahm, Jigui Yu, Hailey P. Weerts, Heather Wenzel, Chitradevi S. Tamilselvi, Lakshmi Chandrasekaran, Marcela F. Pasetti, Sachin Mani, Robert W. Kaminski
Article
Biochemical Research Methods
Sjoerd Rijpkema, Jason Hockley, Alastair Logan, Peter Rigsby, Eleanor Atkinson, Celina Jin, David Goldblatt, Haoyu Liang, Novilia S. Bachtiar, Jae Seung Yang, Akshay Goel, Venkatesan Ramasamy, Marcela F. Pasetti, Andrew J. Pollard
Article
Multidisciplinary Sciences
Nicolas Hegerle, Myeongjin Choi, James Sinclair, Mohammed N. Amin, Morgane Ollivault-Shiflett, Brittany Curtis, Rachel S. Laufer, Surekha Shridhar, Jerod Brammer, Franklin R. Toapanta, Ian Alan Holder, Marcela F. Pasetti, Andrew Lees, Sharon M. Tennant, Alan S. Cross, Raphael Simon
Article
Microbiology
Esther Ndungo, Arlo Randall, Tracy H. Hazen, Dane A. Kania, Krista Trappl-Kimmons, Xiaowu Liang, Eileen M. Barry, Karen L. Kotloff, Subhra Chakraborty, Sachin Mani, David A. Rasko, Marcela F. Pasetti
Article
Immunology
David Bernstein, Marcela F. Pasetti, Rebecca Brady, Amanda D. Buskirk, Rezwanul Wahid, Michelle Dickey, Mitchell Cohen, Holly Baughman, Jill El-Khorazaty, Nicole Maier, Marcelo B. Sztein, Shahida Baqar, A. Louis Bourgeoi
Editorial Material
Microbiology
Michael J. Imperiale, Ira Blader, Patricia Bradford, Sarah D'Orazio, W. Paul Duprex, Craig D. Ellermeier, Ana Fernandez-Sesma, Katherine McMahon, Aaron Mitchell, Marcela F. Pasetti, Susannah Tringe
Article
Immunology
Shannon J. Heine, Olga L. Franco-Mahecha, Khandra T. Sears, Cinthia B. Drachenberg, Maarten L. van Roosmalen, Kees Leenhouts, Wendy L. Picking, Marcela F. Pasetti
JOURNAL OF IMMUNOLOGY
(2019)
Editorial Material
Microbiology
Aaron Mitchell, Ira Blader, Patricia Bradford, Sarah D'Orazio, W. Paul Duprex, Craig D. Ellermeier, Ana Fernandez-Sesma, Michael J. Imperiale, Katherine McMahon, Marcela F. Pasetti, Susannah Tringe
Review
Biotechnology & Applied Microbiology
Esther Ndungo, Marcela F. Pasetti
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2020)
Article
Immunology
F. Heath Damron, Mariette Barbier, Purnima Dubey, Kathryn M. Edwards, Xin-Xing Gu, Nicola P. Klein, Kristina Lu, Kingston H. G. Mills, Marcela F. Pasetti, Robert C. Read, Pejman Rohani, Peter Sebo, Eric T. Harvill
JOURNAL OF IMMUNOLOGY
(2020)
Article
Microbiology
Esther Ndungo, Johanna B. Holm, Syze Gama, Andrea G. Buchwald, Sharon M. Tennant, Miriam K. Laufer, Marcela F. Pasetti, David A. Rasko
Summary: Shigella continues to be a major contributor to diarrheal illness and dysentery in children under 5 in low- and middle-income countries. This study explored the impact of Shigella infection on the developing gastrointestinal microbiome in infants and found temporal changes in the microbiota associated with the infection. These findings highlight the need for further research on the microbial communities associated with disease susceptibility and resolution.
Article
Microbiology
Girmay Desalegn, Neeraj Kapoor, Lucy Pill-Pepe, Leslie Bautista, Lu Yin, Esther Ndungo, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti
Summary: Shigella is responsible for high burdens of global diarrhea and dysentery, especially affecting children in endemic areas. Currently, there are no licensed vaccines to prevent shigellosis. This study reports a novel Shigella OPS conjugate vaccine that uses the Shigella invasion plasmid antigen B (IpaB) as the carrier protein, showing promising immune response and protective antigen properties.
Article
Immunology
Courtney L. Finch, Anding Zhang, Martina Kosikova, Toshiaki Kawano, Marcela F. Pasetti, Zhiping Ye, Jill R. Ascher, Hang Xie
EMERGING MICROBES & INFECTIONS
(2019)
Article
Gastroenterology & Hepatology
Gaelle Noel, Michele Doucet, James P. Nataro, James B. Kaper, Nicholas C. Zachos, Marcela F. Pasetti