期刊
VACCINE
卷 26, 期 35, 页码 4477-4485出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.06.059
关键词
HIV-1; HBV; transgenic plants; VLPs; vaccine; tolerance
资金
- University degli Studi di Milano (Italy)
- CONACYT (Mexico)
- ANRS
- CNRS
Transgenic tobacco plants expressing a HIV-1 polyepitope associated with hepatitis B (HBV) virus-like particles (VLPs) were previously described. It is demonstrated here that oral administration of these transgenic plants to humanized HSB mice to boost DNA-priming can elicit anti-HIV-1 specific CD8+ T cell activation detectable in mesenteric lymph nodes. Nevertheless, a significant regulatory T cell activation was induced in vivo by the vaccination protocols. The balance between tolerance and immunogenicity remains the main concern in the proof of concept of plant-based vaccine. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据