期刊
VACCINE
卷 26, 期 40, 页码 5230-5237出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.03.071
关键词
muscle; skin; immune response; electroporation; DNA vaccine
资金
- VGX Pharmaceuticals (Blue Bell, PA)
Enhancing the expression of DNA vaccines requires that specific conditions of delivery are optimized. We describe experiments using adaptive constant-current electroporation (EP) in mice and pigs examining parameters Such as target muscle, delay between plasmid delivery and onset of EP pulses and DNA vaccine formulation; our studies show that concentrated formulations result in better expression and immunogenicity. Furthermore, various conditions of EP that limit the amount of muscle damage Were measured. The results of these studies will help to advance the success of DNA vaccines in animals into success in human clinical trials. (C) 2008 Elsevier Ltd. All rights reserved.
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