Review
Immunology
Kassandra L. Carpio, Alan D. T. Barrett
Summary: The Flavivirus genus includes many important human pathogens, with NS1 protein playing a crucial role as a diagnostic marker for flavivirus infection. Its roles in disease pathogenesis and protective immunity make NS1 an excellent target for candidate vaccines.
Article
Immunology
Ana Clara Gazzinelli-Guimaraes, Denise Silva Nogueira, Chiara Cassia Oliveira Amorim, Fabricio Marcus Silva Oliveira, Anderson Coqueiro-Dos-Santos, Samuel Alexandre Pimenta Carvalho, Lucas Kraemer, Fernando Sergio Barbosa, Vanessa Gomes Fraga, Flaviane Vieira Santos, Joseane Camilla de Castro, Remo Castro Russo, Milena Apetito Akamatsu, Paulo Lee Ho, Maria Elena Bottazzi, Peter J. Hotez, Bin Zhan, Daniella Castanheira Bartholomeu, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara
Summary: Control of human ascariasis relies on mass drug administration, but a vaccine should be the primary target for infection control. A multipeptide chimera vaccine, ASCVac-1, demonstrated significant efficacy in reducing parasite count in a mouse model through strong IgG-based Th2 immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Na Li, Cheng-Lin Deng, Qi Li, Xiao-Ling Chen, Bo Zhang, Han-Qing Ye
Summary: High titers of replication-defective ZIKV with NS1 deletion (ZIKV-Delta NS1) were generated using the NS1 transcomplementation system. ZIKV-Delta NS1 vaccine induced antibody responses and provided protection against ZIKV infection in mice. Moreover, ZIKV-Delta NS1 vaccination attenuated vertical transmission during pregnancy. These findings highlight the potential of the NS1 trans-complementation system for developing flavivirus vaccines.
ANTIVIRAL RESEARCH
(2023)
Review
Veterinary Sciences
Xingcui Zhang, Yanting Zhang, Renyong Jia, Mingshu Wang, Zhongqiong Yin, Anchun Cheng
Summary: Flaviviruses are enveloped single positive-stranded RNA viruses, with their structural protein C playing a crucial role in the viral life cycle, including encapsulating viral RNA and interacting with host proteins to promote virus proliferation. A better understanding of the function of the C protein can lead to the discovery of novel antiviral strategies.
VETERINARY RESEARCH
(2021)
Article
Medicine, General & Internal
Jiawu Wan, Ting Wang, Jing Xu, Tao Ouyang, Qianruo Wang, Yanni Zhang, Shiqi Weng, Yihan Li, Yu Wang, Xiu Xin, Xiaoling Wang, Sha Li, Lingbao Kong
Summary: LTB-NS1(Delta)(63) demonstrates strong immunogenicity and shows promising results as an oral vaccine in mice. This protein-based mucosa vaccine could serve as a novel approach to combat Japanese encephalitis virus and other flaviviruses effectively.
Article
Biochemistry & Molecular Biology
Stephane Fraga de Oliveira Tosta, Mariana Santana Passos, Rodrigo Kato, Alvaro Salgado, Joilson Xavier, Arun Kumar Jaiswal, Siomar C. Soares, Vasco Azevedo, Marta Giovanetti, Sandeep Tiwari, Luiz Carlos Junior Alcantara
Summary: Yellow fever is a re-emerging major health issue causing recent outbreaks with high mortality rates, mainly affecting tropical countries in Africa and South America. The development of a multi-epitope vaccine for Yellow fever virus using immunoinformatics approaches shows potential in stimulating both humoral and cellular immune responses, making it a candidate for further experimental validation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Immunology
Hao-Long Dong, Mei-Juan He, Qing-Yang Wang, Jia-Zhen Cui, Zhi-Li Chen, Xiang-Hua Xiong, Lian-Cheng Zhang, Hao Cheng, Guo-Qing Xiong, Ao Hu, Yuan-Yuan Lu, Chun-Lin Cheng, Zhi-Xin Meng, Chen Zhu, Guang Zhao, Gang Liu, Hui-Peng Chen
Summary: The genus Flavivirus includes important human and animal pathogens. A simple and rapid method called CPER was used to synthesize recombinant flaviviruses in vertebrate and insect cells. This study established a CPER-based recovery system for flaviviruses of different host ranges.
Article
Veterinary Sciences
Hwi-Yeon Choi, So-Hyun Lee, So-Hyeun Ahn, Jong-Chul Choi, Ji-Yun Jeong, Beom-Joo Lee, Yeong-Lim Kang, Seong-Soo Hwang, Jung-Keun Lee, Sang-Won Lee, Seung-Yong Park, Chang-Seon Song, In-Soo Choi, Joong-Bok Lee
Summary: The chimeric PRRS virus K418DM1.1 is a promising vaccine candidate showing high protective efficacy in both homologous and heterologous challenge studies, along with significant reductions in viremia levels. Field studies also demonstrated lower viremia in vaccinated pigs compared to unvaccinated pigs, suggesting K418DM1.1's effectiveness in real-world scenarios. The safety tests indicated negligible risk of virulence and transmission in both vaccinated and comingled groups, further supporting K418DM1.1 as a good vaccine candidate.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Virology
Qutaiba A. Al Khames Aga, Waseem H. Alkhaffaf, Tagreed H. Hatem, Kawthar F. Nassir, Yazan Batineh, Abdullah T. Dahham, Dimah Shaban, Luma A. Al Khames Aga, Manhal Y. R. Agha, Muaamar Traqchi
Summary: This study investigated the adverse effects associated with three different COVID-19 vaccines and found that local reactions were more common with Pfizer and AstraZeneca vaccines, while systemic events were more prevalent with AstraZeneca and Pfizer vaccines. There was no correlation between age or gender and the duration of adverse effects, and some participants reported unusual symptoms like swelling of eyelids and severe allergic reactions. Overall, Pfizer, AstraZeneca, and Sinopharm vaccines were deemed safe, with Sinopharm showing lower prevalence of adverse effects compared to the others.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
H. Cody Meissner, Stanley A. Plotkin
Summary: The Vaccine Compensation System evaluates associations between vaccination and adverse events to calculate the risk of serious adverse events per million doses given for each vaccine.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
Hwi-Yeon Choi, Min-Sik Kim, Yeong-Lim Kang, Jong-Chul Choi, In-Yeong Choi, Sung-Won Jung, Ji-Yun Jeong, Min-Chul Kim, Seong-Soo Hwang, Sang-Won Lee, Seung-Yong Park, Chang-Seon Song, In-Soo Choi, Joong-Bok Lee
Summary: In this study, a vaccine candidate against Korean lineage-1 PRRSV was developed using reverse genetics technology. The vaccine showed high serum virus neutralization antibody titers in an animal experiment, indicating its potential as a promising vaccine candidate.
VETERINARY SCIENCES
(2022)
Article
Immunology
Gaurav Anand, Saikat Biswas, Nitin Yadav, Paushali Mukherjee, Virander Singh Chauhan
Summary: A fusion chimeric vaccine composed of multiple protective domains was developed to enhance immune responses and reduce morbidity caused by Plasmodium falciparum. The tag-free recombinant PfMSPFu24 was successfully expressed and purified, and shown to be highly immunogenic with a human-compatible adjuvant. Additionally, two dipeptides based hydrogels were investigated as effective delivery platforms for the antigen, showing promising results in stimulating specific antibody titers and invasion inhibitory activity.
Review
Immunology
Rosendo Luria-Perez, Luis A. Sanchez-Vargas, Paola Munoz-Lopez, Gabriela Mellado-Sanchez
Summary: The Flaviviridae family consists of RNA enveloped viruses that cause diseases in humans, with mucosal vaccines showing promise as an alternative route for immunization due to their ability to induce long-term immunity, needle-free administration, and diverse antigen delivery systems.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Susanne Koethe, Patricia Koenig, Kerstin Wernike, Jana Schulz, Ilona Reimann, Martin Beer
Summary: Marker or DIVA vaccines are beneficial for eradicating animal diseases in high prevalence regions. This study developed an efficient BVDV-1 modified double marker vaccine candidate based on the genetic background of Bungowannah virus and showed high level of clinical protection against BVDV-1.
Review
Biotechnology & Applied Microbiology
Mohammad Shoushtari, Farzin Roohvand, Mostafa Salehi-Vaziri, Arash Arashkia, Hasan Bakhshi, Kayhan Azadmanesh
Summary: Flaviviruses are arthropod-borne viruses that pose significant public health problems. While vaccines have been approved for some flaviviruses, there is a lack of effective vaccines for other hazardous flaviviruses. Adenovirus vector-based vaccines are suggested as a promising approach, as demonstrated by their successful use in the COVID-19 pandemic.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Mark R. Schleiss, Ursula Berka, Elizabeth Watson, Mario Aistleithner, Bettina Kiefmann, Bastien Mangeat, Elizabeth C. Swanson, Peter A. Gillis, Nelmary Hernandez-Alvarado, Claudia Fernandez-Alarcon, Jason C. Zabeli, Daniel D. Pinschewer, Anders E. Lilja, Michael Schwendinger, Farshad Guirakhoo, Thomas P. Monath, Klaus K. Orlinger
CLINICAL AND VACCINE IMMUNOLOGY
(2017)
Editorial Material
Immunology
Angus Thomson, Michael Watson
Article
Immunology
Rhonda D. Cardin, Fernando J. Bravo, Derek A. Pullum, Klaus Orlinger, Elizabeth M. Watson, Andreas Aspoeck, Gerhard Fuhrmann, Farshad Guirakhoo, Thomas Monath, David I. Bernstein
Article
Biotechnology & Applied Microbiology
Michael Watson, Eliot Faron de Goer
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2016)
Article
Biotechnology & Applied Microbiology
Kapil Bahl, Joe J. Senn, Olga Yuzhakov, Alex Bulychev, Luis A. Brito, Kimberly J. Hassett, Michael E. Laska, Mike Smith, Orn Almarsson, James Thompson, Amilcar (Mick) Ribeiro, Mike Watson, Tal Zaks, Giuseppe Ciaramella
Article
Multidisciplinary Sciences
Arban Domi, Friederike Feldmann, Rahul Basu, Nathanael McCurley, Kyle Shifflett, Jackson Emanuel, Michael S. Hellerstein, Farshad Guirakhoo, Chiara Orlandi, Robin Flinko, George K. Lewis, Patrick W. Hanley, Heinz Feldmann, Harriet L. Robinson, Andrea Marzi
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Heidi L. Smith, Thomas P. Monath, Pamela Pazoles, Alan L. Rothman, Diane M. Casey, Masanori Terajima, Francis A. Ennis, Farshad Guirakhoo, Sharone Green
JOURNAL OF INFECTIOUS DISEASES
(2011)
Article
Immunology
Rex Biedenbender, Joan Bevilacqua, Anne M. Gregg, Mike Watson, Gustavo Dayan
JOURNAL OF INFECTIOUS DISEASES
(2011)
Editorial Material
Cell Biology
Angus Thomson, Michael Watson
SCIENCE TRANSLATIONAL MEDICINE
(2012)
Article
Multidisciplinary Sciences
Aaron C. Brault, Arban Domi, Erin M. McDonald, Dalit Talmi-Frank, Nathanael McCurley, Rahul Basu, Harriet L. Robinson, Michael Hellerstein, Nisha K. Duggal, Richard A. Bowen, Farshad Guirakhoo
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Robert A Feldman, Rainard Fuhr, Igor Smolenov, Amilcar (Mick) Ribeiro, Lori Panther, Mike Watson, Joseph J. Senn, Mike Smith, Orn Almarsson, Hari S. Pujar, Michael E. Laska, James Thompson, Tal Zaks, Giuseppe Ciaramella
Article
Microbiology
Maria S. Salvato, Arban Domi, Camila Guzman-Cardozo, Sandra Medina-Moreno, Juan Carlos Zapata, Haoting Hsu, Nathanael McCurley, Rahul Basu, Mary Hauser, Michael Hellerstein, Farshad Guirakhoo
Review
Cell Biology
Barton F. Haynes, Lawrence Corey, Prabhavathi Fernandes, Peter B. Gilbert, Peter J. Hotez, Srinivas Rao, Michael R. Santos, Hanneke Schuitemaker, Michael Watson, Ann Arvin
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Nisha K. Duggal, Jana M. Ritter, Erin M. McDonald, Hannah Romo, Farshad Guirakhoo, Brent S. Davis, Gwong-Jen J. Chang, Aaron C. Brault
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2017)
Article
Multidisciplinary Sciences
Andrea Cawein, Emilio Emini, Michael Watson, Joanna Dailey, John Donnelly, Dina Tresnan, Tom Evans, Stanley Plotkin, William Gruber
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2017)
